High-density lipoprotein cholesterol affects early endothelial progenitor cell number and endothelial function in obese women

Obesity ◽  
2013 ◽  
Vol 21 (11) ◽  
pp. 2356-2361 ◽  
Author(s):  
F. Rossi ◽  
C. Bertone ◽  
E. Michelon ◽  
M.J. Bianco ◽  
V. Santiemma
Keyword(s):  
Endothelial Function ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Density Lipoprotein ◽  
Cell Number ◽  
Lipoprotein Cholesterol ◽  
Obese Women ◽  
Endothelial Progenitor

Elevated Monocyte to High-Density Lipoprotein Cholesterol Ratio and Endothelial Dysfunction in Behçet Disease

Angiology ◽  
2017 ◽  
Vol 69 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Nusret Acikgoz ◽  
Ertuğrul Kurtoğlu ◽  
Julide Yagmur ◽  
Yelda Kapicioglu ◽  
Mehmet Cansel ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Brachial Artery ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Behçet Disease ◽  
Cholesterol Ratio

Behçet disease (BD) is a multisystemic disorder characterized by endothelial dysfunction and inflammation. Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged indicator of inflammation and oxidative stress. Sixty patients with BD and 50 control individuals were included to investigate the relationship between MHR and endothelial dysfunction. Endothelial function was assessed by flow- and nitroglycerin-mediated dilatation technique (FMD and NMD, respectively). Serum high-sensitivity C-reactive protein (hsCRP) levels were measured in all study participants. The MHR and hsCRP levels were significantly higher in patients with active BD than in controls. Brachial artery FMD was significantly lower in patients with active BD than in controls. Brachial artery NMD was similar between groups. There was a strong inverse correlation between MHR and FMD and a strong positive correlation between MHR and serum hsCRP levels. Thus, elevated MHR may be a useful marker reflecting impaired endothelial function and systemic inflammation in patients with BD.

Direct association between high-density lipoprotein cholesterol and endothelial function in hyperlipemia

2002 ◽  
Vol 90 (6) ◽  
pp. 648-650 ◽  
Author(s):  
Graziana Lupattelli ◽  
Simona Marchesi ◽  
Anna Rita Roscini ◽  
Donatella Siepi ◽  
Fabio Gemelli ◽  
...  
Keyword(s):  
Endothelial Function ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Direct Association

Abstract 10041: Increased Triglyceride Levels are Associated With Endothelial Dysfunction: FMD-Japan Registry

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Masato Kajikawa ◽  
Yukihito Higashi ◽  
Tatsuya Maruhashi ◽  
Yumiko Iwamoto ◽  
Akimichi Iwamoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Endothelial Function ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional

Objective: In contrast to low-density lipoprotein cholesterol, and high density lipoprotein cholesterol, which are well-established independent risk factors for cardiovascular disease, the importance of triglycerides remains controversial. In this study, we evaluated the associations between triglycerides and endothelial function in the general population. Methods and Results: We enrolled 4,908 subjects (3842 men and 1066 women; mean age, 48±12 years) who were enrolled in FMD-Japan registry. And, we investigated cross-sectional associations between triglycerides and endothelial function by measurement of flow-mediated vasodilation (FMD). The triglycerides levels were negatively associated with FMD (r=-0.10, P<0.001). Subjects were divided into six groups on the basis of the triglycerides level. FMD was significantly decreased with an increase in the triglycerides level (≤63 mg/dL, 7.0±3.5%; 64 to 83 mg/dL, 6.3±3.5%; 84 to 105 mg/dL, 6.0±3.1%; 106 to 131 mg/dL, 5.8±3.2%; 132 to 179 mg/dL, 5.7±3.1%; ≥180 mg/dL, 5.5±3.0%; P for trend<0.001). After adjustment for age, sex, cardiovascular risk factors including high density lipoprotein cholesterol, high triglycerides level groups independently remained associated with low quartile of FMD using the triglycerides ≤63 mg/dL group as the reference (Table). Conclusions: These findings supported an independent association between triglycerides and cardiovascular disease.

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