scholarly journals Impact of participant and interventionist race concordance on weight loss outcomes

Obesity ◽  
2013 ◽  
Vol 21 (4) ◽  
pp. 712-717 ◽  
Author(s):  
Bryan C. Batch ◽  
Jamy D. Ard ◽  
William M. Vollmer ◽  
Kristine Funk ◽  
Lawrence J. Appel ◽  
...  
Obesity ◽  
2012 ◽  
Author(s):  
Bryan C. Batch ◽  
Jamy D. Ard ◽  
William M. Vollmer ◽  
Kristine Funk ◽  
Lawrence J. Appel ◽  
...  

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 828-P
Author(s):  
MARCELA RODRIGUEZ FLORES ◽  
SYLVANA STEPHANO Z. ◽  
MARÍA RABASA ◽  
JUANA MONTOYA ◽  
CLAUDIA VELEZ ◽  
...  

Author(s):  
Istvan Bence Balint ◽  
Ferenc Csaszar ◽  
Krisztian Somodi ◽  
Laszlo Ternyik ◽  
Adrienn Biro ◽  
...  

Abstract Purpose Based on recent scientific evidence, bariatric surgery is more effective in the management of morbid obesity and related comorbidities than conservative therapy. Pylorus preserving surgical procedures (PPBS) such as laparoscopic single-anastomosis duodeno-jejunal or duodeno-ileal bypass with sleeve gastrectomy are modified duodenal switch (DS) surgical techniques. The duodeno-jejunal bypass liner (DJBL) is a novel surgical method in the inventory of metabolism focused manual interventions that excludes duodeno-jejunal mucosa from digestion, mimicking DS procedures without the risk of surgical intervention. The aim of this article is to summarize and compare differences between safety-related features and weight loss outcomes of DJBL and PPBS. Methods A literature search was conducted in the PubMed database. Records of DJBL-related adverse events (AEs), occurrence of PPBS-related complications and reintervention rates were collected. Mean weight, mean body mass index (BMI), percent of excess of weight loss (EWL%), percent of total weight loss (TWL%) and BMI value alterations were recorded for weight loss outcomes. Results A total of 11 publications on DJBL and 6 publications on PPBS were included, involving 800 and 1462 patients, respectively. The baseline characteristics of the patients were matched. Comparison of DJBL-related AEs and PPBS-related severe complications showed an almost equal risk (risk difference (RD): −0.03 and confidence interval (CI): −0.27 to 0.21), despite higher rates among patients having received endoscopic treatment. Overall AE and complication rates classified by Clavien-Dindo showed that PPBS was superior to DJBL due to an excess risk level of 25% (RD: 0.25, CI: 0.01–0.49). Reintervention rates were more favourable in the PPBS group, without significant differences in risk (RD: −0.03, CI: −0.27 to 0.20). However, PPBS seemed more efficient regarding weight loss outcomes at 1-year follow-up according to raw data, while meta-analysis did not reveal any significant difference (odds ratio (OR): 1.08, CI: 0.74–1.59 for BMI changes). Conclusion Only limited conclusions can be made based on our findings. PPBS was superior to DJBL with regard to safety outcomes (GRADE IIB), which failed to support the authors’ hypothesis. Surgical procedures showed lower complication rates than the incidence of DJBL-related AEs, although it should be emphasized that the low number of PPBS-related mild to moderate complications reported could be the result of incomplete data recording from the analysed publications. Weight loss outcomes favoured bariatric surgery (GRADE IIB). As the DJBL is implanted into the upper gastrointestinal tract for 6 to 12 months, it seems a promising additional method in the inventory of metabolic interventions.


2007 ◽  
Vol 107 (10) ◽  
pp. 1755-1767 ◽  
Author(s):  
Marion J. Franz ◽  
Jeffrey J. VanWormer ◽  
A. Lauren Crain ◽  
Jackie L. Boucher ◽  
Trina Histon ◽  
...  

2020 ◽  
pp. 216769682098243
Author(s):  
Autumn Lanoye ◽  
Jessica Gokee LaRose

Social jetlag (SJ)—the shift in sleep timing between workdays and free days—is linked to deleterious cardiometabolic outcomes. SJ is greatest among emerging adults, who are already at high risk for overweight/obesity and experience suboptimal weight loss outcomes. Goals of this ancillary study were to assess SJ among emerging adults enrolled in a 6-month behavioral weight loss trial and examine the association between SJ and treatment outcomes. Bedtime/waketime were self-reported at baseline, and program engagement was monitored throughout the intervention. Weight, waist circumference, and body fat percentage were measured at baseline and post-treatment. Participants (N = 282) reported 1.5 hours of SJ on average, with 30.5% reaching the threshold for clinical significance. There were no significant associations between SJ and program engagement nor between SJ and change in adiposity. Life transitions and chaotic schedules are common during emerging adulthood; thus, further research is needed to capture nuanced patterns of sleep disruption.


Obesity ◽  
2012 ◽  
Vol 20 (7) ◽  
pp. 1413-1418 ◽  
Author(s):  
Tricia M. Leahey ◽  
Rajiv Kumar ◽  
Brad M. Weinberg ◽  
Rena R. Wing

2013 ◽  
Vol 98 (6) ◽  
pp. E1131-E1136 ◽  
Author(s):  
Erica S. Rinella ◽  
Christopher Still ◽  
Yongzhao Shao ◽  
G. Craig Wood ◽  
Xin Chu ◽  
...  

Context: Roux-en-Y gastric bypass (RYGB) is among the most effective treatments for extreme obesity and obesity-related complications. However, despite its potential efficacy, many patients do not achieve and/or maintain sufficient weight loss. Objective: Our objective was to identify genetic factors underlying the variability in weight loss outcomes after RYGB surgery. Design: We conducted a genome-wide association study using a 2-stage phenotypic extreme study design. Setting: Patients were recruited from a comprehensive weight loss program at an integrated health system. Patients: Eighty-six obese (body mass index >35 kg/m2) patients who had the least percent excess body weight loss (%EBWL) and 89 patients who had the most %EBWL at 2 years after surgery were genotyped using Affymetrix version 6.0 single-nucleotide polymorphism (SNP) arrays. A second group from the same cohort consisting of 164 patients in the lower quartile of %EBWL and 169 from the upper quartile were selected for evaluation of candidate regions using custom SNP arrays. Intervention: We performed RYGB surgery. Main Outcome Measures: We assessed %EBWL at 2 years after RYGB and SNPs. Results: We identified 111 SNPs in the first-stage analysis whose frequencies were significantly different between 2 phenotypic extremes of weight loss (allelic χ2 test P < .0001). Linear regression of %EBWL at 2 years after surgery revealed 17 SNPs that approach P < .05 in the validation stage and cluster in or near several genes with potential biological relevance including PKHD1, HTR1A, NMBR, and IGF1R. Conclusions: This is the first genome-wide association study of weight loss response to RYGB. Variation in weight loss outcomes after RYGB may be influenced by several common genetic variants.


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