scholarly journals Subcutaneous adipose cell size and distribution: Relationship to insulin resistance and body fat

Obesity ◽  
2013 ◽  
Vol 22 (3) ◽  
pp. 673-680 ◽  
Author(s):  
T. McLaughlin ◽  
C. Lamendola ◽  
N. Coghlan ◽  
T.C. Liu ◽  
K. Lerner ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Size ◽  
Body Fat ◽  
Adipose Cell ◽  
Subcutaneous Adipose ◽  
Adipose Cell Size

Inflammation and impaired adipogenesis in hypertrophic obesity in man

2009 ◽  
Vol 297 (5) ◽  
pp. E999-E1003 ◽  
Author(s):  
Birgit Gustafson ◽  
Silvia Gogg ◽  
Shahram Hedjazifar ◽  
Lachmi Jenndahl ◽  
Ann Hammarstedt ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Molecular Mechanisms ◽  
Whole Body ◽  
Preadipocyte Differentiation ◽  
Metabolic Complications ◽  
Adipose Cell ◽  
Subcutaneous Adipose ◽  
Adipose Cell Size

Obesity is associated mainly with adipose cell enlargement in adult man (hypertrophic obesity), whereas the formation of new fat cells (hyperplastic obesity) predominates in the prepubertal age. Adipose cell size, independent of body mass index, is negatively correlated with whole body insulin sensitivity. Here, we review recent findings linking hypertrophic obesity with inflammation and a dysregulated adipose tissue, including local cellular insulin resistance with reduced IRS-1 and GLUT4 protein content. In addition, the number of preadipocytes in the abdominal subcutaneous adipose tissue capable of undergoing differentiation to adipose cells is reduced in hypertrophic obesity. This is likely to promote ectopic lipid accumulation, a well-known finding in these individuals and one that promotes insulin resistance and cardiometabolic risk. We also review recent results showing that TNFα, but not MCP-1, resistin, or IL-6, completely prevents normal adipogenesis in preadipocytes, activates Wnt signaling, and induces a macrophage-like phenotype in the preadipocytes. In fact, activated preadipocytes, rather than macrophages, may completely account for the increased release of chemokines and cytokines by the adipose tissue in obesity. Understanding the molecular mechanisms for the impaired preadipocyte differentiation in the subcutaneous adipose tissue in hypertrophic obesity is a priority since it may lead to new ways of treating obesity and its associated metabolic complications.

scholarly journals Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetics

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Jian Yang ◽  
Bjorn Eliasson ◽  
Ulf Smith ◽  
Samuel W. Cushman ◽  
Arthur Sherman
Keyword(s):  
Insulin Resistance ◽  
Cell Size ◽  
Adipose Cell ◽  
Type 2 Diabetics ◽  
Adipose Cell Size

scholarly journals Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetic patients

Adipocyte ◽  
2014 ◽  
Vol 3 (4) ◽  
pp. 314-321 ◽  
Author(s):  
Bjorn Eliasson ◽  
Ulf Smith ◽  
Shawn Mullen ◽  
Samuel W Cushman ◽  
Arthur S Sherman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Size ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Adipose Cell ◽  
Adipose Cell Size ◽  
Type 2 Diabetic

Deletion of the Angiotensin Type 2 Receptor (AT2R) Reduces Adipose Cell Size and Protects From Diet-Induced Obesity and Insulin Resistance

Diabetes ◽  
2005 ◽  
Vol 54 (4) ◽  
pp. 991-999 ◽  
Author(s):  
L. Yvan-Charvet ◽  
P. Even ◽  
M. Bloch-Faure ◽  
M. Guerre-Millo ◽  
N. Moustaid-Moussa ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Size ◽  
Adipose Cell ◽  
Diet Induced Obesity ◽  
Angiotensin Type 2 Receptor ◽  
Adipose Cell Size ◽  
Angiotensin Type

scholarly journals Inflammation in subcutaneous adipose tissue: relationship to adipose cell size

Diabetologia ◽  
2009 ◽  
Vol 53 (2) ◽  
pp. 369-377 ◽  
Author(s):  
T. McLaughlin ◽  
A. Deng ◽  
G. Yee ◽  
C. Lamendola ◽  
G. Reaven ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cell Size ◽  
Subcutaneous Adipose Tissue ◽  
Adipose Cell ◽  
Subcutaneous Adipose ◽  
Adipose Cell Size

Ablation of cholesterol transporter ABCG1 in mice reduces adipose cell size and corrects diet-induced insulin resistance

2006 ◽  
Vol 31 (05) ◽  
Author(s):  
J Buchmann ◽  
C Meyer ◽  
S Neschen ◽  
K Schmolz ◽  
R Augustin ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Size ◽  
Adipose Cell ◽  
Adipose Cell Size

scholarly journals Adipose cell size in obese Africans: evidence against the existence of insulin resistance in some patients.

1979 ◽  
Vol 32 (5) ◽  
pp. 471-474 ◽  
Author(s):  
B I Joffe ◽  
R B Goldberg ◽  
J Feinstein ◽  
A Kark ◽  
H C Seftel
Keyword(s):  
Insulin Resistance ◽  
Cell Size ◽  
Adipose Cell ◽  
Adipose Cell Size
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