An example of a research grant application comprehensive discharge planning for the elderly

Mary D. Naylor

doi:10.1002/nur.4770130509

OP39 Evaluation Of Discharge Planning And Transitional Care For The Elderly

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462318000946 ◽

2018 ◽

Vol 34 (S1) ◽

pp. 15-15

Author(s):

Maggy Wassef ◽

Marc-Olivier Trepanier ◽

Sylvie Beauchamp

Keyword(s):

Readmission Rate ◽

Transitional Care ◽

Discharge Planning ◽

Grey Literature ◽

The Elderly ◽

Narrative Synthesis ◽

Local Data ◽

Post Discharge ◽

Level Of Evidence

Introduction:According to our local data, elderly patients accounted for 14 percent of the population yet, represent 58 percent of hospitalization and, they are more likely to return after discharge. These patients are more likely to return to the hospital following discharge. In order to meet ministerial target for length of stay of patient on a stretcher, the UETMIS-SS was requested to evaluate interventions aiming to improve the fluidity of patient trajectories in the acute care services. The objective of this health technology assessment is to evaluate the effectiveness of discharge planning and transitional care interventions aiming at reducing the readmission rate of the elderly.Methods:An umbrella review was conducted following the PRISMA statement to summarize the scientific evidence. The search was conducted in five databases along with the grey literature search. Two reviewers independently performed the study selection, the quality assessment and the data extraction. To better illustrate the activities and the healthcare professionals (HCP) involved in the interventions, an analytical framework was developed. Results were summarized in a narrative synthesis. The contextual and experiential data were collected through interviews with HCP and directorates from different settings. The level of evidence was and a committee was then held to elaborate the recommendations.Results:In the nine systematic reviews included in the narrative synthesis, three models were identified: Post-discharge planning and follow-up by the same HCP was established to be effective in reducing the readmission rate. Discharge planning interventions with follow-up by non-specific HCP have been shown to be promising, while discharge planning without follow-up after the hospital discharge has shown to be ineffective in reducing the readmission rate.Conclusions:An individualized discharge plan, coordination of services and follow-up performed by the same HCP is established to be effective in reducing readmission rate.

Download Full-text

How to Write a Successful Research Grant Application

10.1007/978-1-4757-2393-9 ◽

1995 ◽

Cited By ~ 2

Keyword(s):

Grant Application ◽

Research Grant

Download Full-text

The research grant application process. Learning from failure?

Higher Education ◽

10.1007/bf00138615 ◽

1992 ◽

Vol 24 (1) ◽

pp. 1-23 ◽

Cited By ~ 6

Author(s):

Fiona Q. Wood ◽

V. Lynn Meek ◽

G. Harman

Keyword(s):

Application Process ◽

Grant Application ◽

Process Learning ◽

Learning From Failure ◽

Research Grant

Download Full-text

The Spectrum of Exomic Mutation in Elderly Myeloma Differs Substantially from Patients at Younger Ages Consistent with a Different Evolutionary Trajectory to Full Blown Disease Based on Age of Onset

Blood ◽

10.1182/blood-2019-130079 ◽

2019 ◽

Vol 134 (Supplement_1) ◽

pp. 4346-4346 ◽

Cited By ~ 2

Author(s):

Louis Williams ◽

Eileen M Boyle ◽

Faith E. Davies ◽

Brian A Walker ◽

Cody Ashby ◽

...

Keyword(s):

Elderly Patients ◽

Copy Number ◽

Research Funding ◽

The Elderly ◽

Mutational Signatures ◽

Advisory Committees ◽

Evolutionary Trajectory ◽

Equity Ownership ◽

Older Populations ◽

Research Grant

Background: An ever improving understanding of the heterogeneity in clinical behavior of multiple myeloma (MM) in older populations supports frailty-adapted therapy as a potential treatment approach. A deeper understanding of the evolutionary trajectory leading to full blown disease in elderly compared to younger patients may give insights into the interplay between mutations and frailty, allowing us to optimize therapy for this group. Methods: We analyzed next generation sequencing data from the Myeloma Genome Project (MGP) (n = 1273, mean age = 65) determining single nucleotide variants (SNV), copy number alterations (CNAs), and mutational signatures to determine age associated patterns. An initial analysis compared a population diagnosed older than age 75 (elderly patients, n = 232, mean age = 80 yrs) in comparison to a group diagnosed at age ≤ 74 (n = 1041, mean age = 62 yrs) and a younger subgroup of patients diagnosed at age ≤ 65 (n = 632, mean age = 57 yrs). Using RNASeq from the same dataset, we will analyze expression of TERT and other shelterin genes in an attempt to correlate changes to age, ATRX mutations, genomic instability, NHEJ, and telomere length as estimated using Telomere Hunter and TelSeq. The aim of this latter analysis being to highlight the importance of telomere biology in determining mutation patterns in the elderly population. Results: We identified age associated patterns in the distribution of mutations with patients age > 74 yrs, when compared to all younger patients showing a significantly greater proportion of SNVs or indels in DIS3 (14.2% vs 8.7%, p = 0.005), HIST1H1E (5.6% vs 3.3%, p = 0.044), and IRF4 (5.6% vs 2.4%, p = 0.005). There were fewer SNVs and indels in CDKN1B (0% vs 1.3%, p = 0.038), FAM46C (6.5% vs 9.7%, p = 0.043), HUWE1 (1.7% vs 6.1%, p = 0.004) and SP140 (0.4% vs 2.9%, p = 0.014). In addition the elderly patient population was found to have proportionally more copy number gains at 1q21: CKS1B (47.4% vs 40.7%, p = 0.031), 5q23: TNFAIP8 (58.2% vs 50.0%, p = 0.012), 5p15: ADCY2 (58.2% vs 50.4%, p =0.016), 6p21: TNXB (39.2% vs 31.4%, p= 0.011), and 17q22: AKAP1 (30.2% vs 23.9%, p = 0.035) along with copy number losses at 16q: CYLD (38.8% vs 32.6%, p = 0.035), 6q25: PARK2 (40.5% vs 33.9% p = 0.028) and 2p23: DNMT3A (28.4% vs 23.0% p = 0.038). A greater proportion of elderly patients exhibited MYC tandem duplications (9.0% vs 5.6%, p = 0.032) while fewer elderly patients harbored MYC translocations (26.2% vs 19.3%, p = 0.015). These differences were further enhanced in comparisons to patients presenting under the age of 65, with elderly patients exhibiting fewer t(4;14) translocations (9.1% vs 14.4%, p = 0.019). Recent data has shown a significant time delay between MM initiation and disease presentation, and mutational signatures have been defined at varying evolutionary trajectories. We have examined if these signatures are different in elderly compared to younger cases. We could not identify a difference in the APOBEC mutational signature between any of the age-based series. We will present further analysis of other signatures and the role of telomere length at the meeting. Conclusions: Our results show significant differences in the genetic alterations between older and younger myeloma patients. These difference may lead to important differences in clinical behavior. The findings suggest disease behavior in the elderly may be driven relatively more frequently by acquired copy number alterations occurring over a period of long disease latency. Ongoing analysis is determining the prognostic impact of mutations in different age strata, which mutational signatures are driving these differences and how these impact clonal structure in the older populations. These results suggest that it should be possible to integrate genetic data and frailty-adaptive risk models to aid in the treatment of multiple myeloma that presents late in life. Disclosures Boyle: Amgen, Janssen, Takeda, Celgene Corporation: Other: Travel expenses; Amgen, Abbvie, Janssen, Takeda, Celgene Corporation: Honoraria. Davies:Amgen, Celgene, Janssen, Oncopeptides, Roche, Takeda: Membership on an entity's Board of Directors or advisory committees, Other: Consultant/Advisor; Janssen, Celgene: Other: Research Grant, Research Funding. Walker:Celgene: Research Funding. Flynt:Celgene Corporation: Employment, Equity Ownership. Thakurta:Celgene: Employment, Equity Ownership. Morgan:Celgene: Other: research grant, Research Funding; Amgen, Roche, Abbvie, Takeda, Celgene, Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees.

Download Full-text

Application of recycled concrete aggregate in mineral-cement-emulsion mixtures

Transportation Overview - Przeglad Komunikacyjny ◽

10.35117/a_eng_18_11_07 ◽

2018 ◽

Vol 2018 (11) ◽

pp. 60-71

Author(s):

Łukasz Skotnicki ◽

Jarosław Kuźniewski

Keyword(s):

Recycled Concrete ◽

Concrete Aggregate ◽

Test Results ◽

Recycled Concrete Aggregate ◽

Grant Application ◽

Strength Parameters ◽

Demolition Waste ◽

Joint Project ◽

National Centre ◽

Research Grant

The article presents selected problems connected with the accomplishment of the research grant ‘Application of reclaimed materials’ as part of the joint project Development of Road Innovations (RID) co-financed by the National Centre of Research and Development as well as the General Directorate for National Roads and Motorways. The main aim of the project was to analyse possibilities of application of reclaimed concrete obtained from the demolition waste from the existing roads to produce new layers of road pavements. The article presents selected test results which show the influence of the reclaimed concrete content on the strength parameters of the MCE mixtures. Significant variation of the tested MCE mixtures properties depending on the percentage of the reclaimed material has been indicated. It has been suggested that new tests should be implemented in the process of MCE mixtures design process. An optimal content of reclaimed concrete has been determined in order to obtain required values of the analysed parameters. The application of reclaimed concrete in conventional MCE mixtures made it possible to achieve positive economical and environmental effects.

Download Full-text

From Writing the Grant to Working the Grant: An Exploration of Processes and Procedures in Transition

Scholarly and Research Communication ◽

10.22230/src.2012v3n1a49 ◽

2012 ◽

Vol 3 (1) ◽

Cited By ~ 1

Author(s):

Lynne Siemens

Keyword(s):

Research Team ◽

Research Collaboration ◽

Research Question ◽

Research Work ◽

Grant Application ◽

Research Teams ◽

Funding Success ◽

Planning Processes ◽

Scholarly Contribution ◽

Research Grant

Fundamental to many projects, a research grant application outlines a research question to be explored as well as its importance and scholarly contribution. This article’s aim is to explore this transition from the grant application to the actual funded research work by examining the experience of INKE, a large interdisciplinary research team. After more than five years of planning and funding success, the research team needed to develop more specific procedures and policies that would facilitate their collaboration than had been outlined in the grant application. Issues under consideration included governance documents, intellectual property policies, leave/exit policies, planning processes, and the inclusion of new researchers and partners. This article will conclude with recommendations on transition and process planning for research teams to ensure effective research collaboration.

Download Full-text