30-day oral toxicity study of domoic acid in Cynomolgus monkeys: Lack of overt toxicity at doses approaching the acute toxic dose

10.1002/nt.5 ◽  
1997 ◽  
Vol 5 (3) ◽  
pp. 111-114 ◽  
Author(s):  
John Truelove ◽  
Rudi Mueller ◽  
Olga Pulido ◽  
Leigh Martin ◽  
Susan Fernie ◽  
...  
Keyword(s):  
Domoic Acid ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Toxic Dose ◽  
Cynomolgus Monkeys ◽  
Acute Toxic

30-day oral toxicity study of domoic acid in Cynomolgus monkeys: Lack of overt toxicity at doses approaching the acute toxic dose

1998 ◽  
Vol 5 (3) ◽  
pp. 111-114
Author(s):  
John Truelove ◽  
Rudi Mueller ◽  
Olga Pulido ◽  
Leigh Martin ◽  
Susan Fernie ◽  
...  
Keyword(s):  
Domoic Acid ◽  
Toxicity Study ◽  
Oral Toxicity ◽  
Toxic Dose ◽  
Cynomolgus Monkeys ◽  
Acute Toxic

A 39-week oral toxicity study of ulipristal acetate in cynomolgus monkeys

2013 ◽  
Vol 66 (1) ◽  
pp. 6-12 ◽  
Author(s):  
Oliver Pohl ◽  
Alistair R.W. Williams ◽  
Christine Bergeron ◽  
Jean-Pierre Gotteland
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Cynomolgus Monkeys ◽  
Ulipristal Acetate

Experimental oral toxicity of domoic acid in cynomolgus monkeys (Macaca fascicularis) and rats.

1990 ◽  
Vol 28 (10) ◽  
pp. 707-715 ◽  
Author(s):  
L. Tryphonas ◽  
J. Truelove ◽  
E. Todd ◽  
E. Nera ◽  
F. Iverson
Keyword(s):  
Domoic Acid ◽  
Macaca Fascicularis ◽  
Oral Toxicity ◽  
Cynomolgus Monkeys

A subchronic oral toxicity study on medical herb extract, KIOM CRC#BP10A, in male and female mice

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
ES Cho ◽  
YJ Lee ◽  
JS Park ◽  
J Kim ◽  
NS Kim ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Male And Female ◽  
Female Mice ◽  
Subchronic Oral Toxicity Study ◽  
Herb Extract

Subchronic 90-day oral toxicity study of Chelidonii herba in pigs

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
P Kosina ◽  
J Drabek ◽  
J Vicar ◽  
J Vostalova ◽  
J Ulrichova ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity

Four-Week Repeated Oral Toxicity Study of Leuconostoc citreum GR1 in Rats

2013 ◽  
Vol 42 (4) ◽  
pp. 600-607 ◽  
Author(s):  
Ah-Ra Kim ◽  
Myung-Yul Lee ◽  
Hae-Choon Chang ◽  
Jae-Joon Lee
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Leuconostoc Citreum

Acute and subacute toxicity assessment of Madhulai Manappagu (Siddha herbal syrup formulation) in animal model

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Meenakshi Sundaram Malayappan ◽  
Gayathri Natarajan ◽  
Logamanian Mockaiyathevar ◽  
Meenakumari Ramasamy
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Oral Route ◽  
Toxicity Assessment ◽  
Toxicity Study ◽  
Female Rats ◽  
Albino Rats ◽  
Oral Toxicity ◽  
Gross Pathology ◽  
Toxicity Studies

Abstract Objectives Madhulai Manappagu – a well-known sastric and widely prescribed Siddha herbal syrup formulation indicated for treating Veluppu Noi (Anaemia especially Iron deficiency Anaemia) has been in day today practice in Tamil Nadu for a quite longer decades. The syrup is a herbal preparation which has a sweet pleasant odour and a palatable taste, contain the juice of pomegranate (Punica granatum L.) as the main ingredient. Though the formulation is a fruit juice, the safety profile of the syrup is not established and is being marketed without toxicological evaluation. The study is aimed at ascertaining the acute and sub-acute toxicity assessment of Madhulai Manappagu in Wistar Albino rats. Methods The acute and sub-acute (28day repeated oral) toxicity studies were performed as per the guidelines mentioned in the Organization for Economic Cooperation and Development (OECD) 423 (adopted on December 2001) and TG 407 (adopted on October 2008) with slight modifications respectively. For acute toxicity study, three female rats were randomly selected as control; three female rats were randomly selected and were administered a single dose of 5,000 mg/kg body weight per oral route. For sub-acute (28day repeated oral) toxicity studies, three doses of test drug MM of 500 mg/kg/day (low dose), 750 mg/kg/day (intermittent dose) and 1,000 mg/kg/day (high dose) were selected for administration. Both sexes of Wistar Albino rats were randomized into four groups of 10 animals each (five males, five females). Group I was kept as control group. Group II, III and IV served as low, intermittent and high doses of MM respectively. Animals were observed for mortality, morbidity, body weight changes, feed and water intake. Haematology, clinical biochemistry, electrolytes, gross pathology, relative organ weight and histopathological examination were performed. Results In the acute toxicity study, rats showed no toxicological signs on behavior, gross pathology and body weight of rats when treated with a single dose of 5,000 mg/kg body weight per oral route. In the subacute (28 days repeated oral) toxicity study, rats have showed no significant changes on behavior, gross pathology, body weight, and hematological and biochemical parameters when treated with Madhulai Manappagu in three different doses. Conclusions The toxicity studies which include both acute and 28 days repeated (subacute) oral toxicity studies, revealed no observed adverse effect level (NOAEL) of Madhulai Manappagu in animals. Thus the safety of the drug in human usage was ensured.

Safety Assessment of a Hydroethanolic Extract of Caralluma fimbriata

2013 ◽  
Vol 32 (5) ◽  
pp. 385-394 ◽  
Author(s):  
Antoinette Y. Odendaal ◽  
Narendra S. Deshmukh ◽  
Tennille K. Marx ◽  
Alexander G. Schauss ◽  
John R. Endres ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Toxicity Study ◽  
Developmental Study ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Toxicological Assessment ◽  
Sprague Dawley Rats ◽  
Chromosomal Aberration Test ◽  
Hydroethanolic Extract

This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), a dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, a repeated dose oral toxicity study, and a developmental study in rats. No evidence of in vitro mutagenicity or clastogenicity surfaced in the in vitro studies at concentrations up to 5000 μg of extract/plate (Ames test) or 5000 μg of extract/mL (chromosomal aberration test). No deaths or treatment-related toxicity were seen in the 6-month chronic oral toxicity study in Sprague-Dawley rats conducted at 3 doses (100, 300, and 1000 mg/kg body weight (bw)/d). The no observed effect level for CFE in this study was considered to be 1000 mg/kg bw/d. A prenatal developmental toxicity study conducted at 3 doses (250, 500, and 1000 mg/kg bw/d) in female Sprague-Dawley rats resulted in no treatment-related external, visceral, or skeletal fetal abnormalities, and no treatment-related maternal or pregnancy alterations were seen at and up to the maximum dose tested. CFE was not associated with any toxicity or adverse events.

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