Potentiation of (DL)-3,4-methylenedioxymethamphetamine (MDMA)-induced toxicity by the serotonin 2A receptior partial agonist d-lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939

2004 ◽  
Vol 35 (2) ◽  
pp. 83-95 ◽  
Author(s):  
Brian D. Armstrong ◽  
Elena Paik ◽  
Seririthanar Chhith ◽  
Vincent Lelievre ◽  
James A. Waschek ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Partial Agonist ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Serotonin 2A ◽  
Mdl 11,939

Lysergic acid diethylamide-induced Fos expression in rat brain: role of serotonin-2A receptors

Neuroscience ◽  
2002 ◽  
Vol 114 (3) ◽  
pp. 707-713 ◽  
Author(s):  
P.J Gresch ◽  
L.V Strickland ◽  
E Sanders-Bush
Keyword(s):  
Rat Brain ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Fos Expression ◽  
Serotonin 2A

scholarly journals Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle

2019 ◽  
Vol 20 (10) ◽  
pp. 2452 ◽  
Author(s):  
Martha López-Canul ◽  
Seung Hyun Min ◽  
Luca Posa ◽  
Danilo De Gregorio ◽  
Annalida Bedini ◽  
...  
Keyword(s):  
Body Temperature ◽  
Receptor Antagonist ◽  
Partial Agonist ◽  
Receptor Subtypes ◽  
Dark Phase ◽  
Light Phase ◽  
Dark Cycle ◽  
Simultaneous Activation ◽  
Type 3 ◽  
G Protein Coupled

Melatonin (MLT) is a neurohormone that regulates many physiological functions including sleep, pain, thermoregulation, and circadian rhythms. MLT acts mainly through two G-protein-coupled receptors named MT1 and MT2, but also through an MLT type-3 receptor (MT3). However, the role of MLT receptor subtypes in thermoregulation is still unknown. We have thus investigated the effects of selective and non-selective MLT receptor agonists/antagonists on body temperature (Tb) in rats across the 12/12-h light–dark cycle. Rectal temperature was measured every 15 min from 4:00 a.m. to 9:30 a.m. and from 4:00 p.m. to 9:30 p.m., following subcutaneous injection of each compound at either 5:00 a.m. or 5:00 p.m. MLT (40 mg/kg) had no effect when injected at 5 a.m., whereas it decreased Tb during the light phase only when injected at 5:00 p.m. This effect was blocked by the selective MT2 receptor antagonist 4P-PDOT and the non-selective MT1/MT2 receptor antagonist, luzindole, but not by the α1/MT3 receptors antagonist prazosin. However, unlike MLT, neither the selective MT1 receptor partial agonist UCM871 (14 mg/kg) nor the selective MT2 partial agonist UCM924 (40 mg/kg) altered Tb during the light phase. In contrast, UCM871 injected at 5:00 p.m. increased Tb at the beginning of the dark phase, whereas UCM924 injected at 5:00 a.m. decreased Tb at the end of the dark phase. These effects were blocked by luzindole and 4P-PDOT, respectively. The MT3 receptor agonist GR135531 (10 mg/kg) did not affect Tb. These data suggest that the simultaneous activation of both MT1 and MT2 receptors is necessary to regulate Tb during the light phase, whereas in a complex but yet unknown manner, they regulate Tb differently during the dark phase. Overall, MT1 and MT2 receptors display complementary but also distinct roles in modulating circadian fluctuations of Tb.

scholarly journals Changes in Online Psychoactive Substance Trade via Telegram during the COVID-19 Pandemic

2021 ◽  
pp. 1-6
Author(s):  
Matthijs Blankers ◽  
Daan van der Gouwe ◽  
Lavinia Stegemann ◽  
Laura Smit-Rigter
Keyword(s):  
Social Media ◽  
The Netherlands ◽  
Relative Increase ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Psychoactive Substance ◽  
Before And After ◽  
Other Substances

<b><i>Background:</i></b> In this article, we present an evaluation of online psychoactive substance trade via Telegram, a free encrypted social media messenger service. The evaluation took place during the COVID-19 pandemic, which allowed us to monitor the effects of the spring 2020 lockdown in the Netherlands on substance trade via Telegram. <b><i>Objective:</i></b> The objective of this study was to evaluate whether changes in psychoactive substance trade on Telegram markets in the Netherlands can be observed during the COVID-19 pandemic. <b><i>Results:</i></b> Between December 2, 2019, and June 29, 2020, a total of 70,226 posts appeared in two analyzed Telegram groups. A total of 5,643 posts were psychoactive substance related. Based on the analyzed posts, Telegram is mostly a ‘“sellers” market as only a minority of the posts (6.3%) could be identified as a request for a substance. The proportion of posts related to specific substances varied between the periods before, during, and after the lockdown. The proportion of posts on the stimulants ecstasy, cocaine, and amphetamine was lower during the lockdown than before and after. For psychedelics – ketamine, lysergic acid diethylamide (LSD), and 2,5-dimethoxy-4-bromophenethylamine (2C-B) – and other substances, there was a relative increase in the number of posts during the lockdown, which was maintained after the lockdown. <b><i>Conclusions:</i></b> Telegram analysis shows that in the Netherlands, online psychoactive substance trade may have been affected during the COVID-19 pandemic. The direction of this effect was different for different classes of substances.

Production of Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide

Science ◽  
1957 ◽  
Vol 126 (3281) ◽  
pp. 1020-1020 ◽  
Author(s):  
H. A. ABRAMSON ◽  
B. SKLAROFSKY ◽  
M. O. BARON ◽  
N. FREMONT-SMITH
Keyword(s):  
Lysergic Acid ◽  
Lysergic Acid Diethylamide
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