Fluoxetine alters mu opiod receptor expression in obese Zucker rat hypothalamus

2004 ◽  
Vol 35 (1) ◽  
pp. 1-7 ◽  
Author(s):  
I. Churruca ◽  
L. Casis ◽  
M.P. Portillo ◽  
M.T. Macarulla ◽  
J. Záate ◽  
...  
Keyword(s):  
Receptor Expression ◽  
Zucker Rat ◽  
Rat Hypothalamus ◽  
Obese Zucker Rat

Effects of Fluoxetine Administration on Regional Galanin Expression in Obese Zucker Rat Hypothalamus

2004 ◽  
Vol 7 (3) ◽  
pp. 171-175 ◽  
Author(s):  
Itziar Churruca ◽  
María P. Portillo ◽  
Arantza Gutiérrez ◽  
Luis Casis ◽  
María Teresa Macarulla ◽  
...  
Keyword(s):  
Zucker Rat ◽  
Rat Hypothalamus ◽  
Obese Zucker Rat

scholarly journals Effects of Fluoxetine Administration on Neuropeptide Y and Orexins in Obese Zucker Rat Hypothalamus

2002 ◽  
Vol 10 (6) ◽  
pp. 532-540 ◽  
Author(s):  
Arantza Gutiérrez ◽  
Gonzalo Saracíbar ◽  
Luis Casis ◽  
Enrique Echevarría ◽  
Víctor Manuel Rodríguez ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Zucker Rat ◽  
Rat Hypothalamus ◽  
Obese Zucker Rat

FLUOXETINE ALTERS MU OPIOID RECEPTOR EXPRESSION IN OBESE ZUCKER RAT EXTRAHYPOTHALAMIC REGIONS

2006 ◽  
Vol 116 (3) ◽  
pp. 289-298 ◽  
Author(s):  
ITZIAR CHURRUCA ◽  
MARÍA P. PORTILLO ◽  
JOSÉ MARÍA ZUMALABE ◽  
MARÍA T. MACARULLA ◽  
LAURA SÁENZ DEL BURGO ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
Receptor Expression ◽  
Zucker Rat ◽  
Mu Opioid ◽  
Obese Zucker Rat

A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model

2017 ◽  
Vol 8 (3) ◽  
pp. 1293-1298 ◽  
Author(s):  
Andrea Bell ◽  
Soheila Korourian ◽  
Huawei Zeng ◽  
Joshua Phelps ◽  
Reza Hakkak
Keyword(s):  
Rat Model ◽  
Liver Steatosis ◽  
Zucker Rat ◽  
Obese Zucker Rat ◽  
Body Weights

Low daidzeinversushigh daidzein mean (±SD) body weights over 8 weeks.

Reduced triglyceride secretion: a metabolic consequence of chronic exercise.

1978 ◽  
Vol 234 (3) ◽  
pp. E221 ◽  
Author(s):  
C Simonelli ◽  
R P Eaton
Keyword(s):  
Exercise Training ◽  
Genetic Model ◽  
Secretion Rate ◽  
Lipid Lowering ◽  
Zucker Rat ◽  
Chronic Exercise ◽  
Similar Reduction ◽  
Triglyceride Secretion ◽  
Obese Zucker Rat

Chronic exercise training is recognized to reduce plasma lipid levels in man and animals, but the mechanism(s) mediating this phenomenon have not been defined. In the present study, we examined triglyceride (TG) production and disposal in vivo in a genetic model of human type IV hyperlipemia, the obese Zucker rat. Utilizing the normolipemic thin littermate as the control, we investigated endogenous production of TG utilizing the Triton methodology and peripheral disposal of an exogenous lipid emulsion utilizing Intralipid injection. In the sedentary state, the hyperlipemic obese Zucker rat demonstrated a threefold elevation in triglyceride secretion rate relative to the normolipemic thin littermate. After a 3-wk period of exercise training, a reduction of basal plasma TG concentration of 42% was associated with a 51% reduction in TG secretion rate, a change adequate to account for the hypolipemic response. Moreover, chronic exercise training also improved the ability to dispose of an Intralipid load. A similar reduction in TG production with reduced TG removal was observed in the thin normolipemic rats, a result that suggests that the lipid lowering response to exercise training may be predominantly mediated by reduced secretion of TG. The possible relationship between reduced TG secretion and alterations in the bihormonal axis of insulin and glucagon are discussed.

Effects of Hypoxia Training on Plasma Leptin, Glucose Uptake in Obese Zucker Rat

2010 ◽  
Vol 42 ◽  
pp. 324
Author(s):  
Te-Chih Liu ◽  
Chien-Wen Hou ◽  
Ying-Lan Tsai ◽  
Mao-Sheng Wu ◽  
Yi-Ming Yeh
Keyword(s):  
Glucose Uptake ◽  
Zucker Rat ◽  
Obese Zucker Rat ◽  
Plasma Leptin

Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat

2003 ◽  
Vol 285 (1) ◽  
pp. E98-E105 ◽  
Author(s):  
Erik J. Henriksen ◽  
Mary K. Teachey ◽  
Zachary C. Taylor ◽  
Stephan Jacob ◽  
Arne Ptock ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Glucose Tolerance ◽  
Glucose Transport ◽  
Zucker Rat ◽  
Transport Activity ◽  
Insulin Resistant ◽  
Obese Zucker Rat ◽  
Cla Isomers ◽  
Muscle Glucose Transport

The fatty acid-conjugated linoleic acid (CLA) enhances glucose tolerance and insulin action on skeletal muscle glucose transport in rodent models of insulin resistance. However, no study has directly compared the metabolic effects of the two primary CLA isomers, cis-9, trans-11-CLA (c9,t11-CLA) and trans-10, cis-12-CLA (t10,c12-CLA). Therefore, we assessed the effects of a 50:50 mixture of these two CLA isomers (M-CLA) and of preparations enriched in either c9,t11-CLA (76% enriched) or t10,c12-CLA (90% enriched) on glucose tolerance and insulin-stimulated glucose transport in skeletal muscle of the insulin-resistant obese Zucker ( fa/ fa) rat. Animals were treated daily by gavage with either vehicle (corn oil), M-CLA, c9,t11-CLA, or t10,c12-CLA (all CLA treatments at 1.5 g total CLA/kg body wt) for 21 consecutive days. During an oral glucose tolerance test, glucose responses were reduced ( P < 0.05) by 10 and 16%, respectively, in the M-CLA and t10,c12-CLA animals, respectively, whereas insulin responses were diminished by 21 and 19% in these same groups. There were no significant alterations in these responses in the c9,t11-CLA group. Insulin-mediated glucose transport activity was enhanced by M-CLA treatment in both type I soleus (32%) and type IIb epitrochlearis (58%) muscles and by 36 and 48%, respectively, with t10,c12-CLA. In the soleus, these increases were associated with decreases in protein carbonyls (index of oxidative stress, r = -0.616, P = 0.0038) and intramuscular triglycerides ( r = -0.631, P = 0.0028). Treatment with c9,t11-CLA was without effect on these variables. These results suggest that the ability of CLA treatment to improve glucose tolerance and insulin-stimulated glucose transport activity in insulin-resistant skeletal muscle of the obese Zucker rat are associated with a reduction in oxidative stress and muscle lipid levels and can be specifically ascribed to the actions of the t10,c12 isomer. In the obese Zucker rat, the c9,t11 isomer of CLA is metabolically neutral.

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