scholarly journals Searching for biomarkers in schizophrenia and psychosis: Case‐control study using capillary electrophoresis and liquid chromatography time‐of‐flight mass spectrometry and systematic review for biofluid metabolites

2021 ◽  
Author(s):  
Saehyeon Kim ◽  
Satoshi Okazaki ◽  
Ikuo Otsuka ◽  
Yutaka Shinko ◽  
Tadasu Horai ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Systematic Review ◽  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
Case Control Study ◽  
Time Of Flight ◽  
Case Control ◽  
Flight Mass Spectrometry ◽  
Control Study

scholarly journals A case–control study of microRNA polymorphisms in gastric cancer screening by SNP chip combined with time of flight mass spectrometry

2020 ◽  
Vol 14 (16) ◽  
pp. 1563-1572
Author(s):  
Chuancheng Wu ◽  
Renjie Han ◽  
Shuangfeng Yang ◽  
Yu Jiang ◽  
Zhixiong Shu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gastric Cancer ◽  
Cancer Screening ◽  
Case Control Study ◽  
Case Control ◽  
Matched Pairs ◽  
Healthy Controls ◽  
Flight Mass Spectrometry ◽  
Gastric Cancer Screening ◽  
Control Study

Aims: To explore new SNP sites of miRNAs associated with gastric cancer, thereby providing valuable biomarkers to diagnose and screen gastric cancer. Materials & methods: A 1:1 case–control study was carried out. Microarrays were used to screen the SNP loci of miRNAs in the genomes of matched pairs of patients, 96 with gastric cancer and 96 healthy controls. For validation, mass spectrometry was used to classify miRNA SNP loci in 622 pairs of subjects. Results: rs7143252 was linked to a higher occurrence of gastric cancer. Conclusion: These results suggest that rs7143252 could be used as a specific biomarker to diagnose and screen gastric cancer.

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