scholarly journals SSRIs: Applications in inflammatory lung disease and implications for COVID‐19

2021 ◽  
Author(s):  
Claire Kyung Sun Meikle ◽  
Justin Fortune Creeden ◽  
Cheryl McCullumsmith ◽  
Randall G. Worth
Keyword(s):  
Lung Disease ◽  
Inflammatory Lung Disease

Metabolic profiling of asthma in mice and the interventional effects of SPA using liquid chromatography and Q-TOF mass spectrometry

2017 ◽  
Vol 13 (6) ◽  
pp. 1172-1181 ◽  
Author(s):  
Li Su ◽  
Lei Shi ◽  
Jian Liu ◽  
Lifei Huang ◽  
Yi Huang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Lung Disease ◽  
Metabolic Profiling ◽  
Inflammatory Lung Disease

Asthma is a chronic inflammatory lung disease that leads to 250 000 deaths annually.

Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model: a translational study

2018 ◽  
Vol 314 (1) ◽  
pp. L32-L53 ◽  
Author(s):  
Dietmar Spengler ◽  
Supandi Winoto-Morbach ◽  
Sarah Kupsch ◽  
Christina Vock ◽  
Katharina Blöchle ◽  
...  
Keyword(s):  
Lung Disease ◽  
Transforming Growth Factor ◽  
Alveolar Epithelial Cell ◽  
Oxygenation Index ◽  
Efficiency Index ◽  
Acid Sphingomyelinase ◽  
Lung Water ◽  
Inflammatory Lung Disease ◽  
Inflammatory Pathways ◽  
Iκb Kinase

The biological and immune-protective properties of surfactant-derived phospholipids and phospholipid subfractions in the context of neonatal inflammatory lung disease are widely unknown. Using a porcine neonatal triple-hit acute respiratory distress syndrome (ARDS) model (repeated airway lavage, overventilation, and LPS instillation into airways), we assessed whether the supplementation of surfactant (S; poractant alfa) with inositol derivatives [inositol 1,2,6-trisphosphate (IP3) or phosphatidylinositol 3,5-bisphosphate (PIP2)] or phosphatidylglycerol subfractions [16:0/18:1-palmitoyloleoyl-phosphatidylglycerol (POPG) or 18:1/18:1-dioleoyl-phosphatidylglycerol (DOPG)] would result in improved clinical parameters and sought to characterize changes in key inflammatory pathways behind these improvements. Within 72 h of mechanical ventilation, the oxygenation index (S+IP3, S+PIP2, and S+POPG), the ventilation efficiency index (S+IP3 and S+POPG), the compliance (S+IP3 and S+POPG) and resistance (S+POPG) of the respiratory system, and the extravascular lung water index (S+IP3 and S+POPG) significantly improved compared with S treatment alone. The inositol derivatives (mainly S+IP3) exerted their actions by suppressing acid sphingomyelinase activity and dependent ceramide production, linked with the suppression of the inflammasome nucleotide-binding domain, leucine-rich repeat-containing protein-3 (NLRP3)-apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-caspase-1 complex, and the profibrotic response represented by the cytokines transforming growth factor-β1 and IFN-γ, matrix metalloproteinase (MMP)-1/8, and elastin. In addition, IκB kinase activity was significantly reduced. S+POPG and S+DOPG treatment inhibited polymorphonuclear leukocyte activity (MMP-8 and myeloperoxidase) and the production of interleukin-6, maintained alveolar-capillary barrier functions, and reduced alveolar epithelial cell apoptosis, all of which resulted in reduced pulmonary edema. S+DOPG also limited the profibrotic response. We conclude that highly concentrated inositol derivatives and phosphatidylglycerol subfractions in surfactant preparations mitigate key inflammatory pathways in inflammatory lung disease and that their clinical application may be of interest for future treatment of the acute exudative phase of neonatal ARDS.

scholarly journals High levels of circulating osteopontin in inflammatory lung disease regardless of Sars‐CoV‐2 infection

2021 ◽  
Author(s):  
Giuseppe Cappellano ◽  
Hugo Abreu ◽  
Davide Raineri ◽  
Lorenza Scotti ◽  
Luigi Castello ◽  
...  
Keyword(s):  
Lung Disease ◽  
Inflammatory Lung Disease

scholarly journals Inflammatory lung disease a potential risk factor for onset of idiopathic inflammatory myopathies: results from a pilot study

RMD Open ◽  
2016 ◽  
Vol 2 (2) ◽  
pp. e000342 ◽  
Author(s):  
Sevim Barbasso Helmers ◽  
Xia Jiang ◽  
David Pettersson ◽  
Anna-Lis Wikman ◽  
Pia Axelman ◽  
...  
Keyword(s):  
Risk Factor ◽  
Pilot Study ◽  
Lung Disease ◽  
Potential Risk ◽  
Potential Risk Factor ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Inflammatory Lung Disease

scholarly journals Runx1 Deficiency in CD4+ T Cells Causes Fatal Autoimmune Inflammatory Lung Disease Due to Spontaneous Hyperactivation of Cells

2012 ◽  
Vol 188 (11) ◽  
pp. 5408-5420 ◽  
Author(s):  
Won Fen Wong ◽  
Kazuyoshi Kohu ◽  
Akira Nakamura ◽  
Masahito Ebina ◽  
Toshiaki Kikuchi ◽  
...  
Keyword(s):  
T Cells ◽  
Lung Disease ◽  
Cd4 T Cells ◽  
Inflammatory Lung Disease
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