scholarly journals GABAergic function in the lateral hypothalamus regulates feeding behavior: Possible mediation via orexin

2019 ◽  
Vol 39 (4) ◽  
pp. 289-296 ◽  
Author(s):  
Naomi Yonemochi ◽  
Chrismawan Ardianto ◽  
Daiki Ueda ◽  
Junzo Kamei ◽  
Hiroko Ikeda
Keyword(s):  
Feeding Behavior ◽  
Lateral Hypothalamus ◽  
Gabaergic Function

Lateral Hypothalamus: Reevaluation of Function in Motivated Feeding Behavior

Science ◽  
1971 ◽  
Vol 172 (3984) ◽  
pp. 744-746 ◽  
Author(s):  
L. D. Devenport ◽  
S. Balagura
Keyword(s):  
Feeding Behavior ◽  
Lateral Hypothalamus

Feeding induced by intracerebroventricular 2-deoxy-D-glucose in the rat

1975 ◽  
Vol 229 (5) ◽  
pp. 1438-1447 ◽  
Author(s):  
RR Miselis ◽  
AN Epstein
Keyword(s):  
Feeding Behavior ◽  
Core Temperature ◽  
Lateral Hypothalamus ◽  
Mode Of Action ◽  
Preoptic Area ◽  
Ventromedial Hypothalamus ◽  
Dependent Manner ◽  
Dose Dependent ◽  
The Brain ◽  
Glucose Analogue

Feeding was induced with lateral intracerebroventricular (ICV) injections of 2-deoxy-D-glucose (2-dg), a glucose analogue causing glucoprivation. Feeding increased rapidly by an average of 2.6 g following ICV 2-DG (2.9 or 5.8 mg per rat), but did not increase after ICV D-glucose or sucrose. At the same doses, 2-DG did not increase feeding when given peripherally. Core temperature dropped in a dose-dependent manner with doses of 2-DG sufficient to induce feeding after peripheral administration, but did not occur with ICV injections. The 2-DG (0.006--1.219 M) did not stimulate feeding when infused bilaterally into the lateral hypothalamus, the preoptic area, or the anterior lateral hypothalamus. Nor did it produce feeding when injected into the ventromedial hypothalamus at the same sites and in the same rats in which procaine HC1 caused increased feeding. The brain, therefore, is directly sensitive to glucoprivation in the control of feeding, and glucoprivation alone is sufficient to mobilize feeding behavior. The specific site of sensitivity to glucoprivation and the mode of action of the glucoprivic system in the brain are unknown.

scholarly journals A role for the locus coeruleus in the modulation of feeding

2019 ◽  
Author(s):  
Natale R. Sciolino ◽  
Christopher M. Mazzone ◽  
Nicholas W. Plummer ◽  
Irina Evsyukova ◽  
Jaisal Amin ◽  
...  
Keyword(s):  
Feeding Behavior ◽  
Locus Coeruleus ◽  
Lateral Hypothalamus ◽  
Nutritional State ◽  
Causal Role ◽  
Noradrenergic Neurons ◽  
Direct Activation ◽  
Endogenous Activity ◽  
Emotion Memory

SUMMARYNoradrenergic neurons of the locus coeruleus (LC-NE) are known to play an important role in arousal, emotion, memory and cognition. In the present study, we use fiber photometry combined with chemogenetic and optogenetic approaches to demonstrate a previously unrecognized role for LC-NE neurons in the modulation of feeding. We show that endogenous activity of LC-NE neurons is enhanced while approaching food and suppressed during feeding. These changes in LC activity during feeding behavior are attenuated as mice approach satiety, demonstrating that nutritional state modulates LC responses to food. Direct activation of LC-NE neurons results in the suppression of feeding. Further, activation of an LC projection to the lateral hypothalamus also suppresses feeding. Together, these findings demonstrate a direct causal role for LC-NE activity in the modulation of feeding.

Dopaminergic mechanisms in the lateral hypothalamus regulate feeding behavior in association with neuropeptides

2019 ◽  
Vol 519 (3) ◽  
pp. 547-552 ◽  
Author(s):  
Naomi Yonemochi ◽  
Chrismawan Ardianto ◽  
Lizhe Yang ◽  
Shogo Yamamoto ◽  
Daiki Ueda ◽  
...  
Keyword(s):  
Feeding Behavior ◽  
Lateral Hypothalamus ◽  
Dopaminergic Mechanisms

scholarly journals Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Ted M Hsu ◽  
Joel D Hahn ◽  
Vaibhav R Konanur ◽  
Emily E Noble ◽  
Andrea N Suarez ◽  
...  
Keyword(s):  
Food Intake ◽  
Environmental Factors ◽  
Feeding Behavior ◽  
Lateral Hypothalamus ◽  
Hippocampal Neurons ◽  
Neural System ◽  
Direct Response ◽  
Feeding Patterns ◽  
Neurobiological Substrates ◽  
Intake Control

Feeding behavior rarely occurs in direct response to metabolic deficit, yet the overwhelming majority of research on the biology of food intake control has focused on basic metabolic and homeostatic neurobiological substrates. Most animals, including humans, have habitual feeding patterns in which meals are consumed based on learned and/or environmental factors. Here we illuminate a novel neural system regulating higher-order aspects of feeding through which the gut-derived hormone ghrelin communicates with ventral hippocampus (vHP) neurons to stimulate meal-entrained conditioned appetite. Additional results show that the lateral hypothalamus (LHA) is a critical downstream substrate for vHP ghrelin-mediated hyperphagia and that vHP ghrelin activated neurons communicate directly with neurons in the LHA that express the neuropeptide, orexin. Furthermore, activation of downstream orexin-1 receptors is required for vHP ghrelin-mediated hyperphagia. These findings reveal novel neurobiological circuitry regulating appetite through which ghrelin signaling in hippocampal neurons engages LHA orexin signaling.

Role of the lateral hypothalamus and the amygdala in feeding behavior

1980 ◽  
Vol 5 ◽  
pp. 143-149 ◽  
Author(s):  
Taketoshi Ono ◽  
Hitoo Nishino ◽  
Kazuo Sasaki ◽  
Masaji Fukuda ◽  
Ken-Ichiro Muramoto
Keyword(s):  
Feeding Behavior ◽  
Lateral Hypothalamus

Role of prefrontal cortex and lateral hypothalamus in feeding behavior

Appetite ◽  
1989 ◽  
Vol 12 (3) ◽  
pp. 228
Author(s):  
T. Ono ◽  
K. Nakamura ◽  
M. Fukuda ◽  
H. Nishino
Keyword(s):  
Prefrontal Cortex ◽  
Feeding Behavior ◽  
Lateral Hypothalamus
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