Transcriptional profiling of brain-derived-neurotrophic factor-induced neuronal plasticity: A novel role for nociceptin in hippocampal neurite outgrowth

2006 ◽  
Vol 66 (4) ◽  
pp. 361-377 ◽  
Author(s):  
Robert H. Ring ◽  
Janet Alder ◽  
Myles Fennell ◽  
Evguenia Kouranova ◽  
Ira B. Black ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Neurotrophic Factor ◽  
Neuronal Plasticity ◽  
Transcriptional Profiling ◽  
Brain Derived Neurotrophic Factor

Epigenetic regulation of brain-derived neurotrophic factor: Implications in neurodevelopment and behavior

2012 ◽  
Vol 35 (5) ◽  
pp. 377-378 ◽  
Author(s):  
Benjamin D. Schanker
Keyword(s):  
Epigenetic Regulation ◽  
Neurotrophic Factor ◽  
Neuronal Plasticity ◽  
Neural Circuits ◽  
Scientific Progress ◽  
Brain Derived Neurotrophic Factor ◽  
Research Findings ◽  
And Behavior

AbstractSeveral recent research findings have implicated brain-derived neurotrophic factor (BDNF) as a mediator of neuronal plasticity. The BDNF gene is under extensive epigenetic regulation, which modulates how much or how little environmental experiences become encoded within neurons and neural circuits. Future scientific progress within the postgenomic paradigm requires elucidation of the functional trajectory in neogenetic and environment interactions.

scholarly journals EphA activation overrides the presynaptic actions of BDNF

2011 ◽  
Vol 105 (5) ◽  
pp. 2364-2374 ◽  
Author(s):  
Caixia Bi ◽  
Xin Yue ◽  
Renping Zhou ◽  
Mark R. Plummer
Keyword(s):  
Neurite Outgrowth ◽  
Neurotrophic Factor ◽  
Hippocampal Neurons ◽  
Synapse Formation ◽  
Brain Derived Neurotrophic Factor ◽  
Synaptic Activity ◽  
Neural Connectivity ◽  
Current Frequency ◽  
Adult Pattern ◽  
Electrophysiological Effects

The adult pattern of neural connectivity is shaped by repulsive and attractive factors, many of which are modulated by activity. Although much is known about the actions of these factors when studied in isolation, little is known about how they interact. To address this question, we examined the effects of sequential or coapplication of brain-derived neurotrophic factor (BDNF) and Fc-conjugated ephrin-A5 or EphA5 in cultured embryonic hippocampal neurons. BDNF promotes neurite outgrowth and synapse formation, and when applied acutely, it elicits an increase in ongoing synaptic activity. Members of the ephrin family of ligands and receptors can be repulsive and prevent formation of synaptic contacts. Acute exposure to either ephrin-A5-Fc or EphA5-Fc transiently enhanced synaptic activity when applied alone, but when applied prior to BDNF, they dramatically reduced the electrophysiological effects of the neurotrophin. Conversely, BDNF had no effect on subsequently applied ephrin-A5-Fc or EphA5-Fc. Consistent with this, ephrin-A5-Fc also prevented BDNF-induced activation of p42/44 MAPK. The effect of ephrin-A5-Fc appears to be presynaptic, as it prevented the BDNF-induced increase in spontaneous miniature postsynaptic current frequency, whereas EphA5-Fc did not. These results suggest that these factors can be categorized differently, with the contact-mediated activation of EphA receptors by ephrin-A5 overriding the diffusion-mediated effect of BDNF.

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