Loss of steroidogenic factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus

2004 ◽  
Vol 60 (4) ◽  
pp. 424-436 ◽  
Author(s):  
Aline M. Davis ◽  
Marianne L. Seney ◽  
Nancy R. Stallings ◽  
Liping Zhao ◽  
Keith L. Parker ◽  
...  
Keyword(s):  
Ventromedial Nucleus ◽  
Steroidogenic Factor 1

Changes in the Expression of Steroidogenic Factor 1 (SF-1) in Neurons in the Ventromedial Nucleus of the Hypothalamus in Rats on Aging

2021 ◽  
Vol 51 (3) ◽  
pp. 346-349
Author(s):  
K. Yu. Moiseev ◽  
A. A. Spirichev ◽  
P. A. Vishnyakova ◽  
A. D. Nozdrachev ◽  
P. M. Masliukov
Keyword(s):  
Ventromedial Nucleus ◽  
Steroidogenic Factor 1

Endogenous BDNF regulates inhibitory synaptic transmission in the ventromedial nucleus of the hypothalamus

2012 ◽  
Vol 107 (1) ◽  
pp. 42-49 ◽  
Author(s):  
Young-Hwan Jo
Keyword(s):  
Patch Clamp ◽  
Kinase Inhibitor ◽  
Melanocortin Receptor ◽  
Pcr Analysis ◽  
Ventromedial Nucleus ◽  
Cellular Mechanisms ◽  
Steroidogenic Factor 1 ◽  
Trkb Receptors ◽  
Whole Cell Patch Clamp ◽  
Gabaergic Synapses

Output from steroidogenic factor-1 (SF-1) neurons in the ventromedial nucleus of the hypothalamus (VMH) is anorexigenic. SF-1 neurons express brain-derived neurotrophic factor (BDNF) that contributes to the regulation of food intake and body weight. Here I show that regulation of GABAergic inputs onto SF-1 neurons by endogenous BDNF determines the anorexigenic outcome from the VMH. Single-cell RT-PCR analysis reveals that one-third of SF-1 neurons express BDNF and that only a subset of BDNF-expressing SF-1 neurons coexpresses the melanocortin receptor type 4. Whole cell patch-clamp analysis of SF-1 neurons in the VMH shows that exogenous BDNF significantly increases the frequency of spontaneous GABAergic inhibitory postsynaptic currents (sIPSCs). This enhancement of GABA drive readily decreases the excitability of SF-1 neurons. However, treatment with BDNF has no significant effect on the frequency of TTX-independent GABAergic IPSCs. Moreover, TrkB receptors are not localized at the postsynaptic sites of GABAergic synapses on SF-1 neurons as there is no change in the amplitude of miniature IPSCs in the presence of BDNF. Dual patch-clamp recordings in mouse hypothalamic slices reveal that stimulation of one SF-1 neuron induces an increase in sIPSC frequency onto the neighboring SF-1 neuron. More importantly, this effect is blocked by a tyrosine kinase inhibitor. Hence, this increased GABA drive onto SF-1 neurons may, in part, explain the cellular mechanisms that mediate the anorexigenic effects of BDNF.

scholarly journals Steroidogenic Factor 1 in the Ventromedial Nucleus of the Hypothalamus Regulates Age-Dependent Obesity

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162352 ◽  
Author(s):  
Ann W. Kinyua ◽  
Dong Joo Yang ◽  
Inik Chang ◽  
Ki Woo Kim
Keyword(s):  
Ventromedial Nucleus ◽  
Steroidogenic Factor 1 ◽  
Age Dependent

scholarly journals VMH neurons under the magnifying glass

Endocrinology ◽  
2021 ◽  
Author(s):  
Tansi Khodai ◽  
Simon M Luckman
Keyword(s):  
Brain Structure ◽  
Glucose Regulation ◽  
Ventromedial Nucleus ◽  
Steroidogenic Factor 1 ◽  
Sexual Behaviours ◽  
Current Review ◽  
Intensive Investigation ◽  
Neuroendocrine Functions

Abstract The ventromedial nucleus of the hypothalamus (VMH) is a complex brain structure that is integral to many neuroendocrine functions, including glucose regulation, thermogenesis, appetitive, social and sexual behaviours. As such, it is of little surprise that the nucleus is under intensive investigation to decipher the mechanisms which underlie these diverse roles. Developments in genetic and investigative tools, for example the targeting of steroidogenic factor-1-expressing neurons, have allowed us to take a closer look at the VMH, its connections and how it affects competing behaviours. In the current review, we aim to integrate recent findings into the literature and contemplate the conclusions that can be drawn.

1824-P: Leptin Receptor Neurons in the Hypothalamic Ventromedial Nucleus Play a Physiological Role in Regulating Glucose Tolerance

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1824-P
Author(s):  
CHELSEA L. FABER ◽  
TRISTA J. HARVEY ◽  
KEVIN R. VELASCO ◽  
VINCENT DAMIAN ◽  
MICHAEL W. SCHWARTZ ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Leptin Receptor ◽  
Physiological Role ◽  
Ventromedial Nucleus ◽  
Receptor Neurons
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