Neuromuscular activity impairs axonal sprouting in partially denervated muscles by inhibiting bridge formation of perisynaptic Schwann cells

2003 ◽  
Vol 57 (2) ◽  
pp. 221-234 ◽  
Author(s):  
S. L. Tam ◽  
T. Gordon
Keyword(s):  
Schwann Cells ◽  
Axonal Sprouting ◽  
Bridge Formation ◽  
Neuromuscular Activity ◽  
Perisynaptic Schwann Cells ◽  
Denervated Muscles

scholarly journals Activity-induced Ca2+ signaling in perisynaptic Schwann cells of the early postnatal mouse is mediated by P2Y1 receptors and regulates muscle fatigue

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Dante J Heredia ◽  
Cheng-Yuan Feng ◽  
Grant W Hennig ◽  
Robert B Renden ◽  
Thomas W Gould
Keyword(s):  
Muscle Fatigue ◽  
Schwann Cells ◽  
Glial Cells ◽  
Nerve Stimulation ◽  
Neural Activity ◽  
Purinergic Receptor ◽  
Cytosolic Calcium ◽  
High Potassium ◽  
Presynaptic Function ◽  
Perisynaptic Schwann Cells

Perisynaptic glial cells respond to neural activity by increasing cytosolic calcium, but the significance of this pathway is unclear. Terminal/perisynaptic Schwann cells (TPSCs) are a perisynaptic glial cell at the neuromuscular junction that respond to nerve-derived substances such as acetylcholine and purines. Here, we provide genetic evidence that activity-induced calcium accumulation in neonatal TPSCs is mediated exclusively by one subtype of metabotropic purinergic receptor. In P2ry1 mutant mice lacking these responses, postsynaptic, rather than presynaptic, function was altered in response to nerve stimulation. This impairment was correlated with a greater susceptibility to activity-induced muscle fatigue. Interestingly, fatigue in P2ry1 mutants was more greatly exacerbated by exposure to high potassium than in control mice. High potassium itself increased cytosolic levels of calcium in TPSCs, a response which was also reduced P2ry1 mutants. These results suggest that activity-induced calcium responses in TPSCs regulate postsynaptic function and muscle fatigue by regulating perisynaptic potassium.

scholarly journals CXCL 12α/ SDF ‐1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals

2017 ◽  
Vol 9 (8) ◽  
pp. 1000-1010 ◽  
Author(s):  
Samuele Negro ◽  
Francesca Lessi ◽  
Elisa Duregotti ◽  
Paolo Aretini ◽  
Marco La Ferla ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Motor Axon ◽  
Axon Terminals ◽  
Perisynaptic Schwann Cells

Transmitter release increases intracellular calcium in perisynaptic schwann cells in situ

Neuron ◽  
1992 ◽  
Vol 8 (6) ◽  
pp. 1069-1077 ◽  
Author(s):  
Babak S. Jahromi ◽  
Richard Robitaille ◽  
Milton P. Charlton
Keyword(s):  
Intracellular Calcium ◽  
Schwann Cells ◽  
Transmitter Release ◽  
Perisynaptic Schwann Cells
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