Age-related differences in synaptic plasticity following muscle unloading

2003 ◽  
Vol 57 (3) ◽  
pp. 246-256 ◽  
Author(s):  
Michael R. Deschenes ◽  
Meredith H. Wilson
Keyword(s):  
Synaptic Plasticity ◽  
Age Related ◽  
Muscle Unloading

scholarly journals Reversal of Age-Related Alterations in Synaptic Plasticity by Blockade of L-Type Ca2+Channels

1998 ◽  
Vol 18 (9) ◽  
pp. 3171-3179 ◽  
Author(s):  
Christopher M. Norris ◽  
Shelley Halpain ◽  
Thomas C. Foster
Keyword(s):  
Synaptic Plasticity ◽  
Age Related ◽  
Ca2 Channels

scholarly journals Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline

2011 ◽  
Vol 43 (1) ◽  
pp. 201-212 ◽  
Author(s):  
Heather D. VanGuilder ◽  
Julie A. Farley ◽  
Han Yan ◽  
Colleen A. Van Kirk ◽  
Matthew Mitschelen ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Cognitive Decline ◽  
Age Related ◽  
Associated Proteins ◽  
Age Related Cognitive Decline

scholarly journals Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting d-serine-dependent NMDA receptor activation

Aging Cell ◽  
2012 ◽  
Vol 11 (2) ◽  
pp. 336-344 ◽  
Author(s):  
Coline Haxaire ◽  
Fabrice R Turpin ◽  
Brigitte Potier ◽  
Myriam Kervern ◽  
Pierre-Marie Sinet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Receptor Activation ◽  
Hippocampal Synaptic Plasticity ◽  
Age Related ◽  
Nmda Receptor Activation

scholarly journals Age-Related Cognitive Impairment: Role of Reduced Synaptobrevin-2 Levels in Deficits of Memory and Synaptic Plasticity

2019 ◽  
Vol 75 (9) ◽  
pp. 1624-1632 ◽  
Author(s):  
Albert Orock ◽  
Sreemathi Logan ◽  
Ferenc Deak
Keyword(s):  
Cognitive Impairment ◽  
Synaptic Plasticity ◽  
Learning And Memory ◽  
Hippocampal Neurons ◽  
Long Term Potentiation ◽  
Receptor Protein ◽  
Protein Levels ◽  
Ca1 Region ◽  
Age Related ◽  
Term Potentiation

AbstractCognitive impairment in the aging population is quickly becoming a health care priority, for which currently no disease-modifying treatment is available. Multiple domains of cognition decline with age even in the absence of neurodegenerative diseases. The cellular and molecular changes leading to cognitive decline with age remain elusive. Synaptobrevin-2 (Syb2), the major vesicular SNAP receptor protein, highly expressed in the cerebral cortex and hippocampus, is essential for synaptic transmission. We have analyzed Syb2 protein levels in mice and found a decrease with age. To investigate the functional consequences of lower Syb2 expression, we have used adult Syb2 heterozygous mice (Syb2+/−) with reduced Syb2 levels. This allowed us to mimic the age-related decrease of Syb2 in the brain in order to selectively test its effects on learning and memory. Our results show that Syb2+/− animals have impaired learning and memory skills and they perform worse with age in the radial arm water maze assay. Syb2+/− hippocampal neurons have reduced synaptic plasticity with reduced release probability and impaired long-term potentiation in the CA1 region. Syb2+/− neurons also have lower vesicular release rates when compared to WT controls. These results indicate that reduced Syb2 expression with age is sufficient to cause cognitive impairment.

17β-estradiol modifies stress-induced and age-related changes in hippocampal synaptic plasticity.

2008 ◽  
Vol 122 (2) ◽  
pp. 301-309 ◽  
Author(s):  
Michael R. Foy ◽  
Michel Baudry ◽  
Judith G. Foy ◽  
Richard F. Thompson
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Synaptic Plasticity ◽  
Age Related ◽  
17Β Estradiol ◽  
Age Related Changes

scholarly journals Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

2014 ◽  
Vol 20 (6) ◽  
pp. 659-663 ◽  
Author(s):  
Saul A Villeda ◽  
Kristopher E Plambeck ◽  
Jinte Middeldorp ◽  
Joseph M Castellano ◽  
Kira I Mosher ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Cognitive Function ◽  
Age Related

Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability

2004 ◽  
Vol 25 (7) ◽  
pp. 955-962 ◽  
Author(s):  
Bryn Williams ◽  
Coran M.H Watanabe ◽  
Peter G Schultz ◽  
Gerald Rimbach ◽  
Thomas Krucker
Keyword(s):  
Synaptic Plasticity ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Age Related
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