Unique biochemical and behavioral alterations indrosophilashibirets1mutants imply a conformational state affecting dynamin subcellular distribution and synaptic vesicle cycling

2002 ◽  
Vol 53 (3) ◽  
pp. 319-329 ◽  
Author(s):  
Mai-Lei Chen ◽  
David Green ◽  
Lei Liu ◽  
Yung Carmen Lam ◽  
Leona Mukai ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Subcellular Distribution ◽  
Conformational State ◽  
Behavioral Alterations ◽  
Vesicle Cycling

Synaptic vesicle cycling at type-identified diaphragm neuromuscular junctions

2004 ◽  
Vol 30 (6) ◽  
pp. 774-783 ◽  
Author(s):  
Carlos B. Mantilla ◽  
Katharine L. Rowley ◽  
Mohamed A. Fahim ◽  
Wen-Zhi Zhan ◽  
Gary C. Sieck
Keyword(s):  
Synaptic Vesicle ◽  
Neuromuscular Junctions ◽  
Vesicle Cycling

scholarly journals Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling

2015 ◽  
Author(s):  
Kate Baker ◽  
Sarah L. Gordon ◽  
Detelina Grozeva ◽  
Margriet van Kogelenberg ◽  
Nicola Y. Roberts ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Vesicle Cycling ◽  
Synaptotagmin 1

scholarly journals β-Hydroxybutyrate supports synaptic vesicle cycling but reduces endocytosis and exocytosis in rat brain synaptosomes

2016 ◽  
Vol 93 ◽  
pp. 73-81 ◽  
Author(s):  
Sviatlana V. Hrynevich ◽  
Tatyana V. Waseem ◽  
Audrey Hébert ◽  
Luc Pellerin ◽  
Sergei V. Fedorovich
Keyword(s):  
Rat Brain ◽  
Synaptic Vesicle ◽  
Rat Brain Synaptosomes ◽  
Vesicle Cycling ◽  
Brain Synaptosomes

scholarly journals Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

Cell Reports ◽  
2017 ◽  
Vol 21 (1) ◽  
pp. 110-125 ◽  
Author(s):  
Alyssa N. Coyne ◽  
Ileana Lorenzini ◽  
Ching-Chieh Chou ◽  
Meaghan Torvund ◽  
Robert S. Rogers ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Multiple Models ◽  
Vesicle Cycling ◽  
Transcriptional Inhibition

scholarly journals Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis

2015 ◽  
Vol 291 (4) ◽  
pp. 1948-1956 ◽  
Author(s):  
Jeffrey R. Cottrell ◽  
Bing Li ◽  
Jae Won Kyung ◽  
Crystle J. Ashford ◽  
James J. Mann ◽  
...  
Keyword(s):  
Human Brain ◽  
Synaptic Vesicle ◽  
Hippocampal Neurons ◽  
Psychiatric Disease ◽  
Specific Function ◽  
Critical Aspect ◽  
Vesicle Cycling ◽  
Presynaptic Function ◽  
Low Expression

Variation in PPP3CC, the gene that encodes the γ isoform of the calcineurin catalytic subunit, has been reported to be associated with schizophrenia. Because of its low expression level in most tissues, there has been little research devoted to the specific function of the calcineurin Aγ (CNAγ) versus the calcineurin Aα (CNAα) and calcineurin Aβ (CNAβ) catalytic isoforms. Consequently, we have a limited understanding of the role of altered CNAγ function in psychiatric disease. In this study, we demonstrate that CNAγ is present in the rodent and human brain and dephosphorylates a presynaptic substrate of calcineurin. Through a combination of immunocytochemistry and immuno-EM, we further show that CNAγ is localized to presynaptic terminals in hippocampal neurons. Critically, we demonstrate that RNAi-mediated knockdown of CNAγ leads to a disruption of synaptic vesicle cycling in cultured rat hippocampal neurons. These data indicate that CNAγ regulates a critical aspect of synaptic vesicle cycling and suggest that variation in PPP3CC may contribute to psychiatric disease by altering presynaptic function.

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