Neural progenitor cells of the neonatal rat anterior subventricular zone express functional GABAA receptors

2002 ◽  
Vol 50 (4) ◽  
pp. 305-322 ◽  
Author(s):  
R.R. Stewart ◽  
G.J. Hoge ◽  
T. Zigova ◽  
M.B. Luskin
Keyword(s):  
Progenitor Cells ◽  
Subventricular Zone ◽  
Gabaa Receptors ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Neonatal Rat ◽  
Anterior Subventricular Zone

scholarly journals Isolation of Neural Progenitor Cells From the Human Adult Subventricular Zone Based on Expression of the Cell Surface Marker CD271

2014 ◽  
Vol 3 (4) ◽  
pp. 470-480 ◽  
Author(s):  
Miriam E. van Strien ◽  
Jacqueline A. Sluijs ◽  
Brent A. Reynolds ◽  
Dennis A. Steindler ◽  
Eleonora Aronica ◽  
...  
Keyword(s):  
Cell Surface ◽  
Progenitor Cells ◽  
Subventricular Zone ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Surface Marker ◽  
Cell Surface Marker ◽  
Human Adult

P2X7 receptors at adult neural progenitor cells of the mouse subventricular zone

2013 ◽  
Vol 73 ◽  
pp. 122-137 ◽  
Author(s):  
Nanette Messemer ◽  
Christin Kunert ◽  
Marcus Grohmann ◽  
Helga Sobottka ◽  
Karen Nieber ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Subventricular Zone ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
P2x7 Receptors

Neural Progenitor Cells Derived from the Adult Rat Subventricular Zone: Characterization and Transplantation

2007 ◽  
Vol 16 (8) ◽  
pp. 799-810 ◽  
Author(s):  
Kevin Chen ◽  
Stephanie M. Hughes ◽  
Bronwen Connor
Keyword(s):  
Progenitor Cells ◽  
Subventricular Zone ◽  
Neural Progenitor Cells ◽  
Therapeutic Potential ◽  
Neural Progenitor ◽  
Adult Rat ◽  
Cell Purification ◽  
Adult Rat Brain ◽  
Percoll Density Gradient

In order to fully characterize and determine the therapeutic potential of adult neural progenitor cells (NPCs), it is important to be able to isolate and study NPCs from animals such as rats, in which there are existing models of brain injury and disease. The focus of this study was to characterize the cultivation, differentiation, and transplantation of adult rat NPCs isolated from the subventricular zone of the lateral ventricles. We examined strategies for cell purification using a Percoll density gradient, and cell expansion using a range of maintenance medium and plating densities. Purification by Percoll gradient enriched a population of cells expressing nestin and SOX2, but resulted in a significant reduction in neurosphere generation. Culturing adult rat NPCs in Neurobasal-A media and plating at 200,000 cell/ml resulted in a higher percentage of cells surviving to generate neurospheres compared to culture in DMEM/F12 or NS-A media. On induction of differentiation, adult rat NPCs were capable of generating neurons, astrocytes, and oligodendrocytes in vitro that survived for up to 8 weeks, demonstrating multipotentiality of these cells. In addition, a population of cells continued to proliferate during the initial phase of differentiation, suggesting the presence of two populations of NPCs during differentiation. Cultured adult rat NPCs also survived and differentiated into astrocytes 6 weeks after transplantation into the striatum of the normal adult rat brain. In conclusion, we have optimized techniques that allow for the routine isolation, culture, and transplantation of multipotent NPCs derived from the adult rat SVZ.

scholarly journals Brief Report: Robo1 Regulates the Migration of Human Subventricular Zone Neural Progenitor Cells During Development

Stem Cells ◽  
2017 ◽  
Vol 35 (7) ◽  
pp. 1860-1865 ◽  
Author(s):  
Hugo Guerrero-Cazares ◽  
Emily Lavell ◽  
Linda Chen ◽  
Paula Schiapparelli ◽  
Montserrat Lara-Velazquez ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Subventricular Zone ◽  
Neural Progenitor Cells ◽  
Neural Progenitor
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