scholarly journals Optimizing Delivery of Breast Milk for Premature Infants: Comparison of Current Enteral Feeding Systems

2019 ◽  
Vol 35 (4) ◽  
pp. 697-702
Author(s):  
Khaled Abdelrahman ◽  
Jane Jarjour ◽  
Joseph Hagan ◽  
Heeju Yang ◽  
Danielle Sutton ◽  
...  
Keyword(s):  
Breast Milk ◽  
Premature Infants ◽  
Enteral Feeding ◽  
Feeding Systems

scholarly journals Clinical effects of breast milk enema on meconium evacuation in premature infants: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Liqiang Zheng ◽  
Li Gai ◽  
Jinyue Gao ◽  
Chaonan Kong ◽  
Yali Wang ◽  
...  
Keyword(s):  
Breast Milk ◽  
Preterm Infants ◽  
Premature Infants ◽  
Enteral Feeding ◽  
Controlled Trial ◽  
Block Design ◽  
Clinical Effects ◽  
Study Results ◽  
Extremely Preterm ◽  
Full Enteral Feeding

Abstract Background Delayed meconium evacuation is an important cause of intestinal dysfunction in preterm infants. There are many methods to induce defecation in preterm infants: however, the effects are controversial. Finding a new intervention method to promote meconium evacuation in premature infants is necessary. Therefore, in the proposed study, the effectiveness of breast milk enema on complete meconium evacuation and time to achieve full enteral feeding will be investigated in preterm infants. Methods/design The study is a randomized, open-label, parallel-group, and single-center clinical trial. A total of 294 preterm infants will be recruited and stratified based on gestational age. Then, the infants will be assigned in a randomized block design to the intervention and control groups with a 1:1 ratio. Preterm infants in the control and intervention groups will receive saline enema and breast milk enema, respectively. The primary outcomes will be the time to achieve complete meconium evacuation from birth and time to achieve full enteral feeding from birth in preterm infants. The secondary outcomes will include hospitalization days, body weight at discharge, duration of total parenteral nutrition, cholestasis, and adverse events. Discussion The results of this trial will determine whether breast milk enema shortens the time to complete meconium evacuation and the time to achieve full enteral feeding in extremely preterm and preterm infants. Furthermore, the study results may provide a new, safe, inexpensive, and easy-to-use intervention to effectively evacuate meconium in preterm infants. Trial registration ISRCTN Registry ISRCTN17847514. Registered on September 14, 2019

Postnatally acquired CMV meningitis diagnosed via BioFire FilmArray: A case report

2020 ◽  
pp. 1-6
Author(s):  
A. Stark ◽  
J. Peterson ◽  
K. Weimer ◽  
C. Hornik
Keyword(s):  
Case Report ◽  
Birth Weight ◽  
Breast Milk ◽  
Premature Infants ◽  
Gold Standard ◽  
Very Low Birth Weight ◽  
Definitive Treatment ◽  
Cmv Infection ◽  
Term Infants ◽  
Low Birth Weight Infant

Postnatally acquired cytomegalovirus (CMV) is commonly acquired via breast milk, with premature infants more frequently developing symptoms of CMV infection in comparison to term infants. Meningitis is a rare clinical manifestation of CMV infection. The diagnosis of meningitis is difficult to make in infants, particularly those who are preterm. Consequentially, broad-spectrum empiric antimicrobial coverage is often administered for several days while waiting for current gold standard CSF testing to result. The BioFire FilmArray (BFA) simultaneously tests for 14 different pathogens, including CMV, allowing for quicker diagnosis and shorter time to definitive treatment. Here, we report a very low birth weight infant with postnatally acquired CMV meningitis, the first to our knowledge to be diagnosed using the BioFire FilmArray.

scholarly journals Might the Mothers of Premature Babies Feed Them and Devote Some Milk to the Milk Bank?

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Pasqua Anna Quitadamo ◽  
Giuseppina Palumbo ◽  
Liliana Cianti ◽  
Matteo Luigi Napolitano ◽  
Ciro Coviello ◽  
...  
Keyword(s):  
Breast Milk ◽  
Premature Infants ◽  
Gestational Age ◽  
Psychological Trauma ◽  
Premature Baby ◽  
Single Donor ◽  
Premature Babies ◽  
Milk Bank ◽  
Starting Point ◽  
Healthy Growth

The breast milk is the gold standard food for the feeding of the premature baby: it is the natural way to provide excellent nutritional, immunological, and biological nutriment so as to facilitate a healthy growth and the development of the infants. When the breast milk is not available, the alternative is represented by the donated milk. The mothers of premature infants are important opportunity if we consider the fact that they could devote some milk both because they provide a food which is closer to the needs of the vulnerable category of newborns and because it is, for the mothers, a way to overcome the detachment and the psychological trauma of a premature birth. There are no data on this kind of donation. The aim of the study is to evaluate the contribution of the milk donation to the HMB of CSS by women who gave birth to premature infants of gestational age <35 weeks and to analyze the macronutrient composition of the “preterm” donated milk. The CSS HMB has recruited 659 donors totalling 2236 liters of donated milk over a period of 7 years. 38 donors (5.7%) gave birth to a gestational age <35 weeks. Almost 20% of the donated milk comes from mothers of premature babies and this is a very important fact because it shows the huge potential belonging to this category of mothers. Taking into account the parameter regarding the birth weight, it was found that VLBW mothers contributed for 56% to preterm donation while ELBW mothers contributed for 41%. By evaluating the variable gestational age, about 40% of the average total donation derives from mothers who gave birth before the 25 weeks, while a contribution of 46% is attributable to the category of newborns with a GA between 25 and 32 weeks. Besides, some other exceptional examples can be outlined. Regarding the correlation analysis DM resulted in negative correlation with GA weeks (r=-0.31, p=0.058) and with BW g (r=-0.30, p=0.068) achieving values which are very close to the significance. The comparison between the donor volume averages of the preterm and full-term groups is statistically significant. The composition data are in line with the literature: there is an increase by 18 % in the protein component of the milk deriving from the mothers of the premature infants; the gap in carbohydrates is less significant (5-6%) and the gap in calories is similarly low being only 2% higher than the single donor milk and 11% more than the pooled milk. The data on the lipids line up to single donor term milk, while it grows by 24% compared to the pooled one. The study shows that even at very low or extreme gestational age it is possible to obtain an appropriate production of breast milk. This awareness becomes a fundamental starting point for the activation in a standardized way of all the strategies of promotion and support of food that have proven effective with the HM in NICU.

scholarly journals Growth Pattern of Early and Late Breast Fed Preterm (30-35 Weeks' Gestation) Neonates: A Hospital Based Study

1970 ◽  
pp. 26-31
Author(s):  
Tahsinul Amin ◽  
MAK Azad Chowdhury ◽  
M Monir Hossain ◽  
M Mahbubul Hoque
Keyword(s):  
Breast Milk ◽  
Breast Feeding ◽  
Enteral Feeding ◽  
Growth Pattern ◽  
Controlled Trial ◽  
Cost Effective ◽  
Preterm Neonates ◽  
Early Feeding ◽  
Breast Fed ◽  
Better Than

Background: There is still controversy among the pediatricians regarding when and how to start enteral feeding in preterm neonates. However, early feeding with breast milk was presumed to be well-tolerated, cost-effective and promote growth better than late feeding. Objectives: To compare growth pattern, benefits and risks between early and late breast feeding in preterm (30-35 weeks' gestation) neonates. Methods: This was a randomized controlled trial. Total 100 preterm neonates were stratified into early feeding (n=50) and late feeding (n=50) groups. Early feeding was started on day 3 and late feeding on day 5 of life with expressed breast milk as 20 ml/ kg/day by gavage feeding with daily increment 20 ml/kg till full enteral feeding. Growth was recorded by anthropometric measurements with accuracy and precision for first 3 months of life. Results: Early breast feeding was found to be significantly better than late breast feeding in duration to reach full feeding (13.08 days vs. 16.70 days), time to regain enrolment weight (10.87 days vs. 13.70 days), feed tolerance (78% vs. 58%), hospital stay (13.58 days vs. 16.82 days), mean weight (3773.62 ±310.49 gm vs. 3636.91 ±340.20 gm), linear growth (53.64 ±2.26 cm vs. 52.62 ±2.04 cm) and OFC growth (35.85 ±1.50 cm vs. 35.35 ±1.40 cm) at 3 months of age. Conclusion: Early feeding with breast milk is well tolerated with less morbidity and promotes growth better than late feeding in preterm neonates. Key words: Growth pattern; preterm; breast fed DOI: 10.3329/bjch.v31i1.6071 Bangladesh Journal of Child Health 2007; Vol.31(1-3): 26-31

Bacterial toxins and enteral feeding of premature infants at risk for necrotizing enterocolitis

1998 ◽  
Vol 10 (2) ◽  
pp. 211-219 ◽  
Author(s):  
Linda C. Duffy ◽  
Maria A. Zielezny ◽  
Vivien Carrion ◽  
Elizabeth Griffiths ◽  
Diane Dryja ◽  
...  
Keyword(s):  
At Risk ◽  
Necrotizing Enterocolitis ◽  
Premature Infants ◽  
Enteral Feeding ◽  
Bacterial Toxins

Variation in Enteral Feeding Practices and Growth Outcomes among Very Premature Infants: A Report from the New York State Perinatal Quality Collaborative

2015 ◽  
Vol 33 (01) ◽  
pp. 009-019 ◽  
Author(s):  
Eileen Shields ◽  
Deborah Campbell ◽  
Adriann Combs ◽  
Michael Horgan ◽  
Edmund La Gamma ◽  
...  
Keyword(s):  
New York ◽  
Premature Infants ◽  
Enteral Feeding ◽  
New York State ◽  
Feeding Practices ◽  
York State ◽  
Growth Outcomes ◽  
Very Premature Infants

scholarly journals Hypervirulent Streptococcus agalactiae septicemia in twin ex-premature infants transmitted by breast milk: report of source detection and isolate characterization using commonly available molecular diagnostic methods

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Edward P. C. Ager ◽  
Eric D. Steele ◽  
Lindsey E. Nielsen ◽  
Matthew A. Nestander ◽  
Katrin Mende ◽  
...  
Keyword(s):  
Breast Milk ◽  
Premature Infants ◽  
Streptococcus Agalactiae ◽  
Early Onset ◽  
Limit Of Detection ◽  
Late Onset ◽  
Perinatal Transmission ◽  
Diagnostic Methods ◽  
Molecular Methods ◽  
Molecular Diagnostic

Abstract Background Group B Streptococcus (GBS) infections caused by Streptococcus agalactiae is a leading cause of meningitis and sepsis in neonates, with early-onset GBS symptoms emerging during the first week of life and late-onset occurring thereafter. Perinatal transmission of GBS to the neonate through the birth canal is the main factor associated with early-onset neonate infections, while less is understood about the source of late-onset infections. Methods In this report we describe a case of twin ex-premature infants who presented one month after birth with GBS septicemia. The mother had been appropriately screened at gestational age 35–37 weeks and laboratory methods failed to detect GBS colonization by culture or clinical molecular methods. In attempts to identify and isolate the source of GBS infection, additional surveillance swabs were collected from the mother at the time of neonate admission. Culture and a commercially available, FDA-cleared molecular PCR assay were performed. Results No GBS was detected from swabs collected from the perianal, thigh/groin or axillary areas. However, expressed breast milk and swabs from the breastmilk pump were positive by both methods. Since simultaneous culture and molecular methods which used breastmilk as a source were performed, investigators ascertained the limit of detection for GBS in breastmilk. The limit of detection was determined to be tenfold lower than that of LIM-broth enriched cultures—the FDA-approved source. Subsequent whole genome sequencing (WGS) analysis of isolates recovered from breastmilk and blood cultures from the infants demonstrated all strains were related and characterized as ST-452. Both infants responded very well to treatment and continued to have no related events or concerns at the two-year follow up appointment. Conclusions Strain type 452 (capsular type IV) has recently emerged as a hypervirulent strain and has previously been documented as causing GBS infections in elderly populations. Antibiotic therapy resolved both mother and infant infections. Subsequent testing for the presence of GBS in breastmilk samples also showed an absence of bacteria. This is the first report of infant twins late-onset GBS infections caused by the hypervirulent S. agalactiae ST-452 with breastmilk as the source.

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