Effect of a Probiotic Preparation on Ventilator-Associated Pneumonia in Critically Ill Patients Admitted to the Intensive Care Unit: A Prospective Double-Blind Randomized Controlled Trial

2018 ◽  
Vol 34 (1) ◽  
pp. 156-162 ◽  
Author(s):  
Ata Mahmoodpoor ◽  
Hadi Hamishehkar ◽  
Roghaieh Asghari ◽  
Ramin Abri ◽  
Kamran Shadvar ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Randomized Controlled Trial ◽  
Intensive Care ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Controlled Trial ◽  
Ventilator Associated Pneumonia ◽  
Double Blind ◽  
Randomized Controlled ◽  
Probiotic Preparation

A double-blind, randomized controlled trial of gabapentin vs. placebo for acute pain management in critically ill patients with rib fractures

Injury ◽  
2018 ◽  
Vol 49 (9) ◽  
pp. 1693-1698 ◽  
Author(s):  
Eliza E. Moskowitz ◽  
Lucin Garabedian ◽  
Kimberly Hardin ◽  
Emily Perkins-Pride ◽  
Menilik Asfaw ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Pain Management ◽  
Critically Ill ◽  
Acute Pain ◽  
Critically Ill Patients ◽  
Controlled Trial ◽  
Rib Fractures ◽  
Acute Pain Management ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals Outcome of Critically ill Patients Undergoing Mandatory Insulin Therapy Compared to Usual Care Insulin Therapy: Protocol for a Pilot Randomized Controlled Trial� (Preprint)

2016 ◽  
Author(s):  
Peter J Watkinson ◽  
Vicki S Barber ◽  
J Duncan Young
Keyword(s):  
Randomized Controlled Trial ◽  
Intensive Care ◽  
Insulin Therapy ◽  
Usual Care ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Controlled Trial ◽  
Blood Glucose Control ◽  
Complication Rates ◽  
Randomized Controlled

BACKGROUND Observational and interventional studies in patients with both acute medical conditions and long-standing diabetes have shown that improved blood glucose control confers a survival advantage or reduces complication rates. Policies of “tight” glycaemic control were rapidly adopted by many general intensive care units (ICUs) worldwide in the mid 00’s, even though the results of the studies were not generalizable to mixed medical/surgical ICUs with different intravenous feeding policies. OBJECTIVE The primary objective of the study is to assess the safety of mandatory insulin infusion in critically ill patients in a general ICU setting. METHODS This protocol summarizes the rationale and design of a randomized, controlled, single-center trial investigating the effect of mandatory insulin therapy versus usual care insulin therapy for those patients admitted for a stay of longer than 48 hours. In total, 109 critically ill adults predicted to stay in intensive care for longer than 48 hours consented. The primary outcome is to determine the safety of mandatory insulin therapy in critically ill patients using the number of episodes of hypoglycaemia and hypokalaemia per unit length of stay in intensive care. Secondary outcomes include the duration of mechanical ventilation, duration of ICU and hospital stay, hospital mortality, and measures of renal, hepatic, and haematological dysfunction. RESULTS The project was funded in 2005 and enrolment was completed 2007. Data analysis is currently underway and the first results are expected to be submitted for publication in 2018. CONCLUSIONS This protocol for a randomized controlled trial investigating the effect of mandatory insulin therapy should provide an answer to a key question for the management of patients in the ICU and ultimately improving outcome. CLINICALTRIAL International Standard Randomized Controlled Trial Number ISRCTN00550641; http://www.isrctn.com/ISRCTN00550641 (Archived at WebCite: http://www.webcitation.org/6xk8NXxNv).

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