1 H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration

2004 ◽  
Vol 17 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Marrita M. Mahon ◽  
Andreanna D. Williams ◽  
W. Patrick Soutter ◽  
I. Jane Cox ◽  
G. Angus McIndoe ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Ex Vivo ◽  
Invasive Cervical Cancer ◽  
In Vivo Study ◽  
Resonance Spectroscopy

scholarly journals Proton Magnetic Resonance Spectroscopy Characterization of Rathke’s Cleft Cysts (RCCs): Relevance to the Differential Diagnosis of Pituitary Adenomas and RCCs

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 360
Author(s):  
Omkar B. Ijare ◽  
Martyn A. Sharpe ◽  
David S. Baskin ◽  
Kumar Pichumani
Keyword(s):  
Differential Diagnosis ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Pituitary Adenomas ◽  
Ex Vivo ◽  
Medical Professionals ◽  
Resonance Spectroscopy ◽  
Rathke's Cleft Cysts ◽  
Rathke's Cleft

Background: Rathke’s Cleft Cysts (RCCs) are rare epithelial cysts arising from remnants of the Rathke pouch in the pituitary gland. A subset of these lesions enlarge and produce a mass effect with consequent hypopituitarism, and may result in visual loss. Moreover, some RCCs with a high intra-cystic protein content may mimic cystic pituitary adenoma, which makes their differential diagnosis ambiguous. Currently, medical professionals have no definitive way to distinguish RCCs from pituitary adenomas. Therefore, preoperative confirmation of RCCs would be of help to medical professionals for the management and proper surgical decision making. The goal of this study is to identify molecular markers in RCCs. Methods: We characterized aqueous and chloroform extracts of surgically resected RCCs and pituitary adenomas using ex vivo 1H NMR spectroscopy. Results: All RCCs exclusively showed the presence of mucopolysaccharides which are glycosaminoglycans (GAGs) made up of disaccharides of aminosugars and uronic sugars. Conclusion: GAGs can be used as metabolite marker for the detection of RCCs and this knowledge will lay the groundwork for the development of a non-invasive, in vivo magnetic resonance spectroscopy methodology for the differential diagnosis of RCCs and pituitary adenomas using clinical MRI scanners.

In Vivo and Ex Vivo Magnetic Resonance Spectroscopy in the Characterization of Hemangioblastoma Cyst Fluid

2014 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Girolamo Crisi ◽  
Silvano Filice ◽  
Thelma A. Pertinhez ◽  
Elisa Ventura ◽  
Franco Servadei
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Ex Vivo ◽  
Cyst Fluid ◽  
Resonance Spectroscopy

In vivo study of brain metabolism in galactosemia by1H and31P magnetic resonance spectroscopy

1995 ◽  
Vol 154 (S2) ◽  
pp. S8-S13 ◽  
Author(s):  
Harald E. Möller ◽  
Kurt Ullrich ◽  
Peter Vermathen ◽  
Gerhard Schuierer ◽  
Hans-Georg Koch
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Metabolism ◽  
In Vivo Study ◽  
Resonance Spectroscopy

scholarly journals Metabolic Profiling of the Rat Liver After Chronic Ingestion of Alpha-Naphthylisothiocyanate Using In Vivo and Ex Vivo Magnetic Resonance Spectroscopy

2012 ◽  
Vol 126 (2) ◽  
pp. 306-316 ◽  
Author(s):  
B. S. Solanky ◽  
G. J. Sanchez-Canon ◽  
J. F. L. Cobbold ◽  
S. D. Taylor-Robinson ◽  
J. D. Bell ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Rat Liver ◽  
Metabolic Profiling ◽  
Ex Vivo ◽  
Resonance Spectroscopy ◽  
Chronic Ingestion
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