High-resolution magic angle spinning MRS of breast cancer tissue

2002 ◽  
Vol 15 (5) ◽  
pp. 327-337 ◽  
Author(s):  
Beathe Sitter ◽  
Ursula Sonnewald ◽  
Manfred Spraul ◽  
Hans E. Fjösne ◽  
Ingrid S. Gribbestad
Keyword(s):  
Breast Cancer ◽  
High Resolution ◽  
Magic Angle Spinning ◽  
Breast Cancer Tissue ◽  
Cancer Tissue ◽  
Magic Angle ◽  
Angle Spinning

scholarly journals HR-MAS NMR Based Quantitative Metabolomics in Breast Cancer

Metabolites ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 19 ◽  
Author(s):  
Mikheil Gogiashvili ◽  
Jessica Nowacki ◽  
Roland Hergenröder ◽  
Jan G. Hengstler ◽  
Jörg Lambert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pulse Sequences ◽  
Quantitative Information ◽  
Magic Angle Spinning ◽  
Cancer Tissue ◽  
Magic Angle ◽  
Quantitative Metabolomics ◽  
Minimal Sample ◽  
Angle Spinning ◽  
Non Destructive

High resolution magic-angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy is increasingly used for profiling of breast cancer tissue, delivering quantitative information for approximately 40 metabolites. One unique advantage of the method is that it can be used to analyse intact tissue, thereby requiring only minimal sample preparation. Importantly, since the method is non-destructive, it allows further investigations of the same specimen using for instance transcriptomics. Here, we discuss technical aspects critical for a successful analysis — including sample handling, measurement conditions, pulse sequences for one- and two dimensional analysis, and quantification methods - and summarize available studies, with a focus on significant associations of metabolite levels with clinically relevant parameters.

scholarly journals Intratumoral Agreement of High-Resolution Magic Angle Spinning Magnetic Resonance Spectroscopic Profiles in the Metabolic Characterization of Breast Cancer

Medicine ◽  
2016 ◽  
Vol 95 (15) ◽  
pp. e3398 ◽  
Author(s):  
Vivian Youngjean Park ◽  
Dahye Yoon ◽  
Ja Seung Koo ◽  
Eun-Kyung Kim ◽  
Seung Il Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Angle Spinning

Cervical cancer tissue characterized by high-resolution magic angle spinning MR spectroscopy

2004 ◽  
Vol 16 (4) ◽  
pp. 174-181 ◽  
Author(s):  
Beathe Sitter ◽  
Tone Bathen ◽  
Bj� �rn Hagen ◽  
Cecilie Arentz ◽  
Finn Egil Skjeldestad ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Resolution ◽  
Mr Spectroscopy ◽  
Magic Angle Spinning ◽  
Cancer Tissue ◽  
Magic Angle ◽  
Cervical Cancer Tissue ◽  
Angle Spinning

Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning1H NMR spectroscopy

2017 ◽  
Vol 31 (2) ◽  
pp. e3862 ◽  
Author(s):  
Mikheil Gogiashvili ◽  
Salome Horsch ◽  
Rosemarie Marchan ◽  
Kathrin Gianmoena ◽  
Cristina Cadenas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nmr Spectroscopy ◽  
High Resolution ◽  
Breast Cancer Tissue ◽  
Intratumoral Heterogeneity ◽  
Cancer Tissue ◽  
Magic Angle ◽  
Quantitative Metabolomics

Processing of high resolution magic angle spinning spectra of breast cancer cells by the filter diagonalization method

The Analyst ◽  
2012 ◽  
Vol 137 (19) ◽  
pp. 4546 ◽  
Author(s):  
Roberta Manzano Maria ◽  
Tiago Bueno Moraes ◽  
Claudio José Magon ◽  
Tiago Venâncio ◽  
Wanessa Fernanda Altei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Resolution ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Filter Diagonalization ◽  
Diagonalization Method ◽  
Angle Spinning ◽  
Filter Diagonalization Method
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