1H- and31P-MR spectroscopy of primary and recurrent human brain tumorsin vitro: malignancy-characteristic profiles of water soluble and lipophilic spectral components

2001 ◽  
Vol 14 (5) ◽  
pp. 307-317 ◽  
Author(s):  
Fritz-Georg Lehnhardt ◽  
Gabriele Röhn ◽  
Ralf-Ingo Ernestus ◽  
Matthias Grüne ◽  
Mathias Hoehn
Keyword(s):  
Human Brain ◽  
Mr Spectroscopy ◽  
Water Soluble ◽  
Spectral Components

In-vivo proton MR-spectroscopy of the human brain: Assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration

Amino Acids ◽  
2002 ◽  
Vol 23 (1-3) ◽  
pp. 317-323 ◽  
Author(s):  
W. Block ◽  
F. Träber ◽  
S. Flacke ◽  
F. Jessen ◽  
C. Pohl ◽  
...  
Keyword(s):  
Human Brain ◽  
Mr Spectroscopy ◽  
Proton Mr Spectroscopy

Localized 2DJ-resolved H MR spectroscopy of human brain tumorsin vivo

1996 ◽  
Vol 6 (3) ◽  
pp. 453-459 ◽  
Author(s):  
M. Albert Thomas ◽  
Lawrence N. Ryner ◽  
Minesh P. Mehta ◽  
Patrick A. Turski ◽  
James A. Sorenson
Keyword(s):  
Human Brain ◽  
Mr Spectroscopy

Quantitative Proton MR Spectroscopy of the Human Brain

1994 ◽  
pp. 219-223
Author(s):  
O. Henriksen ◽  
P. Christiansen ◽  
H. B. W. Larsson ◽  
M. Stubgaard
Keyword(s):  
Human Brain ◽  
Mr Spectroscopy ◽  
Proton Mr Spectroscopy

scholarly journals How the Chemical Properties of GBCAs Influence Their Safety Profiles In Vivo

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 58
Author(s):  
Quyen N. Do ◽  
Robert E. Lenkinski ◽  
Gyula Tircso ◽  
Zoltan Kovacs
Keyword(s):  
Human Brain ◽  
Chemical Properties ◽  
Point Of View ◽  
Water Soluble ◽  
Soluble Form ◽  
Clinical Implications ◽  
Kinetic Properties ◽  
Gadolinium Retention ◽  
Open Question

The extracellular class of gadolinium-based contrast agents (GBCAs) is an essential tool for clinical diagnosis and disease management. In order to better understand the issues associated with GBCA administration and gadolinium retention and deposition in the human brain, the chemical properties of GBCAs such as relative thermodynamic and kinetic stabilities and their likelihood of forming gadolinium deposits in vivo will be reviewed. The chemical form of gadolinium causing the hyperintensity is an open question. On the basis of estimates of total gadolinium concentration present, it is highly unlikely that the intact chelate is causing the T1 hyperintensities observed in the human brain. Although it is possible that there is a water-soluble form of gadolinium that has high relaxitvity present, our experience indicates that the insoluble gadolinium-based agents/salts could have high relaxivities on the surface of the solid due to higher water access. This review assesses the safety of GBCAs from a chemical point of view based on their thermodynamic and kinetic properties, discusses how these properties influence in vivo behavior, and highlights some clinical implications regarding the development of future imaging agents.

PROPERTIES AND CLASSIFICATION OF THE SOLUBLE ESTERASES OF HUMAN BRAIN

1966 ◽  
Vol 44 (2) ◽  
pp. 225-232 ◽  
Author(s):  
D. J. Ecobichon
Keyword(s):  
Alkaline Phosphatase ◽  
Human Brain ◽  
Esterase Activity ◽  
Water Soluble ◽  
Human Tissues ◽  
Esterase Pattern ◽  
Vertical Zone ◽  
Zone Electrophoresis ◽  
Starch Gel

Water-soluble proteins and enzymes of human brain were separated by vertical zone electrophoresis in starch gel. Fifteen bands of esterase activity were detected in brain. Various substrates and inhibitors were used in efforts to identify enzymes in addition to a comparison of the esterase pattern with patterns obtained from other human tissues. One zone, composed of four bands of acetylesterase activity, was found to be common to all the tissues investigated with the exception of serum. Two bands of cholinesterase and two bands of A-esterase activity were identified. The remaining bands, which were aliesterases possessing broad overlapping substrate specificity and inhibitor sensitivity, were electrophoretically different from those of other tissues. Observations on alkaline phosphatase, acid phosphatase, and lactate dehydrogenase were recorded for comparison with the data on esterases.

scholarly journals Phase-rotated MR spectroscopy using dual-PRESS: theory and application in human brain

2007 ◽  
Author(s):  
Saadallah Ramadan ◽  
M. Albert Thomas ◽  
Carolyn E. Mountford ◽  
Onur Seref ◽  
O. Erhun Kundakcioglu ◽  
...  
Keyword(s):  
Human Brain ◽  
Mr Spectroscopy

1H MR Spectroscopy of human brain tumors: a practical approach

2009 ◽  
Vol 33 (1) ◽  
pp. 78
Author(s):  
V. Callot ◽  
D. Galanaud ◽  
Y. Le Fur ◽  
S. Confort-Gouny ◽  
J.-P. Ranjeva ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Mr Spectroscopy ◽  
Practical Approach ◽  
Human Brain Tumors ◽  
1H Mr Spectroscopy
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