scholarly journals Whole‐brain high‐resolution metabolite mapping with 3D compressed‐sensing SENSE low‐rank 1 H FID‐MRSI

2021 ◽  
Author(s):  
Antoine Klauser ◽  
Paul Klauser ◽  
Frédéric Grouiller ◽  
Sébastien Courvoisier ◽  
François Lazeyras
2020 ◽  
Author(s):  
Antoine Klauser ◽  
Bernhard Strasser ◽  
Bijaya Thapa ◽  
Francois Lazeyras ◽  
Ovidiu Andronesi

Low sensitivity MR techniques such as magnetic resonance spectroscopic imaging (MRSI) greatly benefit from the gain in signal-to-noise (SNR) provided by ultra-high field MR. High-resolution and whole-brain slab MRSI remains however very challenging due to lengthy acquisition, low signal, lipid contamination and field inhomogeneity. In this study, we propose an acquisition-reconstruction scheme that combines a 1H-FID-MRSI sequence with compressed sensing acceleration and low-rank modeling with total-generalized-variation constraint to achieve metabolite imaging in two and three dimensions at 7 Tesla. The resulting images and volumes reveal highly detailed distributions that are specific to each metabolite and follow the underlying brain anatomy. The MRSI method was validated in a high-resolution phantom containing fine metabolite structures, and in 3 healthy volunteers. This new application of compressed sensing acceleration paves the way for high-resolution MRSI in clinical setting with acquisition times of 5 min for 2D MRSI at 2.5 mm and of 20 min for 3D MRSI at 3.3 mm isotropic.


2020 ◽  
Author(s):  
Antoine Klauser ◽  
Paul Klauser ◽  
Frédéric Grouiller ◽  
Sebastien Courvoisier ◽  
Francois Lazeyras

There is a growing interest of the neuroscience community to map the distribution of brain metabolites in vivo. Magnetic resonance spectroscopy imaging (MRSI) is often limited by either a poor spatial resolution and/or a long acquisition time which severely limits its applications for clinical or research purposes. We developed a novel acquisition-reconstruction technique combining fast 1H-FID-MRSI sequence accelerated by random k-space undersampling and a low-rank and total-generalized variation (TGV) constrained model. This framework was applied to the brain of four healthy volunteers. Following 20 min acquisition, reconstruction and quantification, the resulting metabolic maps with a 5 mm isotropic resolution reflected the detailed neurochemical composition of all brain regions and revealed part of the underlying brain anatomy. Contrasts and features from the 3D metabolite distributions were in agreement with the literature and consistent across the four subjects. The successful combination of the 3D 1H-FID-MRSI with a constrained reconstruction enables the detailed mapping of metabolite concentrations at high-resolution in the whole brain and with an acquisition time that is compatible with clinical or research settings.


2021 ◽  
pp. 107048
Author(s):  
Antoine Klauser ◽  
Bernhard Strasser ◽  
Bijaya Thapa ◽  
Francois Lazeyras ◽  
Ovidiu Andronesi

Author(s):  
Mei Sun ◽  
Jinxu Tao ◽  
Zhongfu Ye ◽  
Bensheng Qiu ◽  
Jinzhang Xu ◽  
...  

Background: In order to overcome the limitation of long scanning time, compressive sensing (CS) technology exploits the sparsity of image in some transform domain to reduce the amount of acquired data. Therefore, CS has been widely used in magnetic resonance imaging (MRI) reconstruction. </P><P> Discussion: Blind compressed sensing enables to recover the image successfully from highly under- sampled measurements, because of the data-driven adaption of the unknown transform basis priori. Moreover, analysis-based blind compressed sensing often leads to more efficient signal reconstruction with less time than synthesis-based blind compressed sensing. Recently, some experiments have shown that nonlocal low-rank property has the ability to preserve the details of the image for MRI reconstruction. Methods: Here, we focus on analysis-based blind compressed sensing, and combine it with additional nonlocal low-rank constraint to achieve better MR images from fewer measurements. Instead of nuclear norm, we exploit non-convex Schatten p-functionals for the rank approximation. </P><P> Results & Conclusion: Simulation results indicate that the proposed approach performs better than the previous state-of-the-art algorithms.


2008 ◽  
Vol 61 (1) ◽  
pp. 103-116 ◽  
Author(s):  
Hong Jung ◽  
Kyunghyun Sung ◽  
Krishna S. Nayak ◽  
Eung Yeop Kim ◽  
Jong Chul Ye

2015 ◽  
Vol 204 (3) ◽  
pp. 510-518 ◽  
Author(s):  
Hadrien A. Dyvorne ◽  
Ashley Knight-Greenfield ◽  
Cecilia Besa ◽  
Nancy Cooper ◽  
Julio Garcia-Flores ◽  
...  

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