Lactate infusion increases brain energy content during euglycemia but not hypoglycemia in healthy men

2019 ◽  
Vol 32 (11) ◽  
Author(s):  
Juliane Richter ◽  
Doerte Rabe ◽  
Kai Duysen ◽  
Uwe H. Melchert ◽  
Kerstin M. Oltmanns
Keyword(s):  
Energy Content ◽  
Healthy Men ◽  
Lactate Infusion ◽  
Brain Energy

scholarly journals Blood Lactate is an Important Energy Source for the Human Brain

2009 ◽  
Vol 29 (6) ◽  
pp. 1121-1129 ◽  
Author(s):  
Gerrit van Hall ◽  
Morten Stømstad ◽  
Peter Rasmussen ◽  
Øle Jans ◽  
Morten Zaar ◽  
...  
Keyword(s):  
Energy Source ◽  
Human Brain ◽  
Arterial Lactate ◽  
Oxidation Rates ◽  
Lactate Uptake ◽  
Lactate Utilization ◽  
Lactate Infusion ◽  
The Brain ◽  
Brain Energy

Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate kinetics and oxidation rates in 6 healthy individuals at rest with and without 90 mins of intravenous lactate infusion (36 μmol per kg bw per min), and during 30mins of cycling exercise at 75% of maximal oxygen uptake while the lactate infusion continued to establish arterial lactate concentrations of 0.89 ± 0.08, 3.9 ± 0.3, and 6.9 ± 1.3 mmol/L, respectively. At rest, cerebral lactate utilization changed from a net lactate release of 0.06 ± 0.01 to an uptake of 0.16 ± 0.07 mmol/min during lactate infusion, with a concomitant decrease in the net glucose uptake. During exercise, the net cerebral lactate uptake was further increased to 0.28 ± 0.16 mmol/min. Most 13C-label from cerebral [1-13C]lactate uptake was released as 13CO2 with 100% ± 24%, 86% ± 15%, and 87% ± 30% at rest with and without lactate infusion and during exercise, respectively. The contribution of systemic lactate to cerebral energy expenditure was 8% ± 2%, 19% ± 4%, and 27% ± 4% for the respective conditions. In conclusion, systemic lactate is taken up and oxidized by the human brain and is an important substrate for the brain both under basal and hyperlactatemic conditions.

scholarly journals Mobile Phone Radiation Deflects Brain Energy Homeostasis and Prompts Human Food Ingestion

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 339
Author(s):  
Ewelina Wardzinski ◽  
Kamila Jauch-Chara ◽  
Sarah Haars ◽  
Uwe Melchert ◽  
Harald Scholand-Engler ◽  
...  
Keyword(s):  
Food Intake ◽  
Mobile Phone ◽  
Electromagnetic Fields ◽  
Mobile Phones ◽  
Energy Homeostasis ◽  
Energy Content ◽  
Resonance Spectroscopy ◽  
Brain Functions ◽  
Mobile Phone Radiation ◽  
Brain Energy

Obesity and mobile phone usage have simultaneously spread worldwide. Radio frequency-modulated electromagnetic fields (RF-EMFs) emitted by mobile phones are largely absorbed by the head of the user, influence cerebral glucose metabolism, and modulate neuronal excitability. Body weight adjustment, in turn, is one of the main brain functions as food intake behavior and appetite perception underlie hypothalamic regulation. Against this background, we questioned if mobile phone radiation and food intake may be related. In a single-blind, sham-controlled, randomized crossover comparison, 15 normal-weight young men (23.47 ± 0.68 years) were exposed to 25 min of RF-EMFs emitted by two different mobile phone types vs. sham radiation under fasting conditions. Spontaneous food intake was assessed by an ad libitum standard buffet test and cerebral energy homeostasis was monitored by 31phosphorus-magnetic resonance spectroscopy measurements. Exposure to both mobile phones strikingly increased overall caloric intake by 22–27% compared with the sham condition. Differential analyses of macronutrient ingestion revealed that higher calorie consumption was mainly due to enhanced carbohydrate intake. Measurements of the cerebral energy content, i.e., adenosine triphosphate and phosphocreatine ratios to inorganic phosphate, displayed an increase upon mobile phone radiation. Our results identify RF-EMFs as a potential contributing factor to overeating, which underlies the obesity epidemic. Beyond that, the observed RF-EMFs-induced alterations of the brain energy homeostasis may put our data into a broader context because a balanced brain energy homeostasis is of fundamental importance for all brain functions. Potential disturbances by electromagnetic fields may therefore exert some generalized neurobiological effects, which are not yet foreseeable.

scholarly journals Net energy value of two low-digestible carbohydrates, Lycasin®HBC and the hydrogenated polysaccharide fraction of Lycasin®HBC in healthy human subjects and their impact on nutrient digestive utilization

2002 ◽  
Vol 87 (2) ◽  
pp. 131-139 ◽  
Author(s):  
S. Sinaud ◽  
C. Montaurier ◽  
D. Wils ◽  
J. Vernet ◽  
M. Brandolini ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Energy Content ◽  
Metabolizable Energy ◽  
Whole Body ◽  
Net Energy ◽  
Adaptation Period ◽  
Healthy Men ◽  
Polysaccharide Fraction ◽  
Energy Value ◽  
Net Energy Value

The metabolizable energy content of low-digestible carbohydrates does not correspond with their true energy value. The aim of the present study was to determine the tolerance and effects of two polyols on digestion and energy expenditure in healthy men, as well as their digestible, metabolizable and net energy values. Nine healthy men were fed for 32 d periods a maintenance diet supplemented either with dextrose, Lycasin®HBC (Roquette Frères, Lestrem, France), or the hydrogenated polysaccharide fraction of Lycasin®HBC, at a level of 100 g DM/d in six equal doses per d according to a 3×3 Latin square design with three repetitions. After a 20 d progressive adaptation period, food intake was determined for 12 d using the duplicate meal method and faeces and urine were collected for 10 d for further analyses. Subjects spent 36 h in one of two open-circuit whole-body calorimeters with measurements during the last 24 h. Ingestion of the polyols did not cause severe digestive disorders, except excessive gas emission, and flatulence and gurgling in some subjects. The polyols induced significant increases in wet (+45 and +66 % respectively, P<0·01) and dry (+53 and +75 % respectively, P<0·002) stool weight, resulting in a 2 % decrease in dietary energy digestibility (P<0·001). They resulted also in significant increases in sleeping (+4·1 %, P<0·03) and daily energy expenditure (+2·7 and +2·9 % respectively, P<0·02) compared with dextrose ingestion. The apparent energy digestibility of the two polyols was 0·82 and 0·79 respectively, their metabolizable energy value averaged 14·1 kJ/g DM, and their net energy value averaged 10·8 kJ/g DM, that is, 35 % less than those of sucrose and starch.

scholarly journals CNF1 Enhances Brain Energy Content and Counteracts Spontaneous Epileptiform Phenomena in Aged DBA/2J Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0140495 ◽  
Author(s):  
Sara Travaglione ◽  
Giulia Ballan ◽  
Andrea Fortuna ◽  
Alberto Ferri ◽  
Marco Guidotti ◽  
...  
Keyword(s):  
Energy Content ◽  
Brain Energy

scholarly journals Test-meal palatability is associated with overconsumption but better represents preceding changes in appetite in non-obese males

2016 ◽  
Vol 116 (5) ◽  
pp. 935-943 ◽  
Author(s):  
Kevin Deighton ◽  
James Frampton ◽  
Javier T. Gonzalez
Keyword(s):  
Energy Intake ◽  
Food Consumption ◽  
Energy Content ◽  
Ecological Validity ◽  
High Energy ◽  
Strongly Correlated ◽  
Healthy Men ◽  
Energy Compensation ◽  
Ad Libitum ◽  
Experimental Trials

AbstractSingle-course,ad libitummeals are recommended for the assessment of energy intake within appetite research. This study represents the first investigation of the comparative sensitivity of two single-course,ad libitummeals designed to differ in palatability. We conducted two experiments using a preload study design. All protocols were identical except for the energy content of the preloads (Expt 1: 579 and 1776 kJ; Expt 2: 828 and 4188 kJ). During each experiment, ten healthy men completed four experimental trials constituting a low- or high-energy preload beverage, a 60-min intermeal interval and consumption of a pasta-based or a porridge-based,ad libitummeal. Appetite ratings were measured throughout each trial, and palatability was assessed after food consumption. Preload manipulation did not influence appetite (P=0·791) or energy intake (P=0·561) in Expt 1. Palatability and energy intake were higher for the pasta meal than for the porridge meal in both experiments (palatabilityP≤0·002; energy intakeP≤0·001). In Expt 2, consumption of the high-energy preload decreased appetite (P=0·051) and energy intake (P=0·002). Energy compensation was not significantly different between pasta and porridge meals (P=0·172), but was more strongly correlated with preceding changes in appetite at the pasta meal (r−0·758;P=0·011) than the porridge meal (r−0·498;P=0·143). The provision of a highly palatable, pasta-based meal produced energy intakes that were more representative of preceding appetite ratings, but the moderately palatable, porridge-based meal produced more ecologically valid energy intakes.Ad libitummeal selection and design may require a compromise between sensitivity and ecological validity.

Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

Appetite ◽  
2012 ◽  
Vol 58 (3) ◽  
pp. 818-821 ◽  
Author(s):  
Bernd Schultes ◽  
Sebastian M. Schmid ◽  
Britta Wilms ◽  
Kamila Jauch-Chara ◽  
Kerstin M. Oltmanns ◽  
...  
Keyword(s):  
Food Intake ◽  
Healthy Men ◽  
Lactate Infusion

CFTR protein expression in healthy men spermatozoa is not correlated with fertilization rate of ova

2010 ◽  
Vol 34 (8) ◽  
pp. S12-S12
Author(s):  
Hong‑Ge Li ◽  
Chen Min Xu ◽  
Kun Li ◽  
Ya Ni ◽  
Wen‑Ying Chen ◽  
...  
Keyword(s):  
Protein Expression ◽  
Fertilization Rate ◽  
Healthy Men ◽  
Cftr Protein

Demonstrating Nutrient Cost Gradients: A Brooklyn Case Study

2014 ◽  
Vol 84 (5-6) ◽  
pp. 244-251 ◽  
Author(s):  
Robert J. Karp ◽  
Gary Wong ◽  
Marguerite Orsi
Keyword(s):  
Low Income ◽  
Energy Content ◽  
Food Selection ◽  
The United States ◽  
United States Department ◽  
Micronutrient Deficiencies ◽  
Caloric Density ◽  
Low Income Families ◽  
The Cost ◽  
The Impact

Abstract. Introduction: Foods dense in micronutrients are generally more expensive than those with higher energy content. These cost-differentials may put low-income families at risk of diminished micronutrient intake. Objectives: We sought to determine differences in the cost for iron, folate, and choline in foods available for purchase in a low-income community when assessed for energy content and serving size. Methods: Sixty-nine foods listed in the menu plans provided by the United States Department of Agriculture (USDA) for low-income families were considered, in 10 domains. The cost and micronutrient content for-energy and per-serving of these foods were determined for the three micronutrients. Exact Kruskal-Wallis tests were used for comparisons of energy costs; Spearman rho tests for comparisons of micronutrient content. Ninety families were interviewed in a pediatric clinic to assess the impact of food cost on food selection. Results: Significant differences between domains were shown for energy density with both cost-for-energy (p < 0.001) and cost-per-serving (p < 0.05) comparisons. All three micronutrient contents were significantly correlated with cost-for-energy (p < 0.01). Both iron and choline contents were significantly correlated with cost-per-serving (p < 0.05). Of the 90 families, 38 (42 %) worried about food costs; 40 (44 %) had chosen foods of high caloric density in response to that fear, and 29 of 40 families experiencing both worry and making such food selection. Conclusion: Adjustments to USDA meal plans using cost-for-energy analysis showed differentials for both energy and micronutrients. These differentials were reduced using cost-per-serving analysis, but were not eliminated. A substantial proportion of low-income families are vulnerable to micronutrient deficiencies.

Sign in / Sign up

Export Citation Format

Share Document