scholarly journals A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis

2018 ◽  
Vol 32 (1) ◽  
pp. e4029 ◽  
Author(s):  
Elianna A. Bier ◽  
Scott H. Robertson ◽  
Geoffry M. Schrank ◽  
Craig Rackley ◽  
Joseph G. Mammarappallil ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Exchange Spectroscopy ◽  
Cardiogenic Oscillations

scholarly journals Quantification of pulmonary perfusion in idiopathic pulmonary fibrosis with first pass dynamic contrast-enhanced perfusion MRI

Thorax ◽  
2020 ◽  
pp. thoraxjnl-2019-214375
Author(s):  
Nicholas D Weatherley ◽  
James A Eaden ◽  
Paul J C Hughes ◽  
Matthew Austin ◽  
Laurie Smith ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Pulmonary Function Tests ◽  
Pulmonary Vascular Disease ◽  
Bolus Transit ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
First Pass

IntroductionIdiopathic pulmonary fibrosis (IPF) is a fatal disease of lung scarring. Many patients later develop raised pulmonary vascular pressures, sometimes disproportionate to the interstitial disease. Previous therapeutic approaches that have targeted pulmonary vascular changes have not demonstrated clinical efficacy, and quantitative assessment of regional pulmonary vascular involvement using perfusion imaging may provide a biomarker for further therapeutic insights.MethodsWe studied 23 participants with IPF, using dynamic contrast-enhanced MRI (DCE-MRI) and pulmonary function tests, including forced vital capacity (FVC), transfer factor (TLCO) and coefficient (KCO) of the lungs for carbon monoxide. DCE-MRI parametric maps were generated including the full width at half maximum (FWHM) of the bolus transit time through the lungs. Key metrics used were mean (FWHMmean) and heterogeneity (FWHMIQR). Nineteen participants returned at 6 months for repeat assessment.ResultsSpearman correlation coefficients were identified between TLCO and FWHMIQR (r=−0.46; p=0.026), KCO and FWHMmean (r=−0.42; p=0.047) and KCO and FWHMIQR (r=−0.51; p=0.013) at baseline. No statistically significant correlations were seen between FVC and DCE-MRI metrics. Follow-up at 6 months demonstrated statistically significant decline in FVC (p=0.040) and KCO (p=0.014), with an increase in FWHMmean (p=0.040), but no significant changes in TLCO (p=0.090) nor FWHMIQR (p=0.821).ConclusionsDCE-MRI first pass perfusion demonstrates correlations with existing physiological gas exchange metrics, suggesting that capillary perfusion deficit (as well as impaired interstitial diffusion) may contribute to gas exchange limitation in IPF. FWHMmean showed a significant increase over a 6-month period and has potential as a quantitative biomarker of pulmonary vascular disease progression in IPF.

Gas Exchange And Outcome Prediction In Idiopathic Pulmonary Fibrosis

2011 ◽  
Author(s):  
Jaime Hook ◽  
Selim M. Arcasoy ◽  
David Zemmel ◽  
Matthew Bartels ◽  
Steven M. Kawut ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Outcome Prediction

Comparison Of Sleep And Exercise Gas Exchange In Patients With Stable Idiopathic Pulmonary Fibrosis

2010 ◽  
Author(s):  
Ruth N.C. Lee ◽  
Emer M. Kelly ◽  
Geraldine M. Nolan ◽  
Michael P. Keane ◽  
Walter T. McNicholas
Keyword(s):  
Gas Exchange ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis

scholarly journals Cellular Mechanisms of Tissue Fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis

2014 ◽  
Vol 306 (11) ◽  
pp. C987-C996 ◽  
Author(s):  
Christina E. Barkauskas ◽  
Paul W. Noble
Keyword(s):  
Gas Exchange ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Current Knowledge ◽  
Alveolar Epithelium ◽  
Scar Formation ◽  
Current Understanding ◽  
Cellular Mechanisms ◽  
Tissue Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by severe and progressive scar formation in the gas-exchange regions of the lung. Despite years of research, therapeutic treatments remain elusive and there is a pressing need for deeper mechanistic insights into the pathogenesis of the disease. In this article, we review our current knowledge of the triggers and/or perpetuators of pulmonary fibrosis with special emphasis on the alveolar epithelium and the underlying mesenchyme. In doing so, we raise a number of questions highlighting critical voids and limitations in our current understanding and study of this disease.

Gas exchange at a given degree of volume restriction is different in sarcoidosis and idiopathic pulmonary fibrosis

1988 ◽  
Vol 85 (2) ◽  
pp. 221-224 ◽  
Author(s):  
Thaddeus L. Dunn ◽  
Leslie C. Watters ◽  
Clarence Hendrix ◽  
Reuben M. Cherniack ◽  
Marvin I. Schwarz ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis

Mechanisms of Gas-exchange Impairment in Idiopathic Pulmonary Fibrosis

1991 ◽  
Vol 143 (2) ◽  
pp. 219-225 ◽  
Author(s):  
Alvar G. N. Agustí ◽  
Josep Roca ◽  
Joaquim Gea ◽  
Peter D. Wagner ◽  
Antoni Xaubet ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis
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