scholarly journals Diffusional kurtosis imaging and white matter microstructure modeling in a clinical study of major depressive disorder

2018 ◽  
Vol 31 (7) ◽  
pp. e3938 ◽  
Author(s):  
Kouhei Kamiya ◽  
Naohiro Okada ◽  
Kingo Sawada ◽  
Yusuke Watanabe ◽  
Ryusuke Irie ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Clinical Study ◽  
White Matter ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Diffusional Kurtosis Imaging ◽  
Microstructure Modeling ◽  
White Matter Microstructure

Impact of early and recent stress on white matter microstructure in major depressive disorder

2018 ◽  
Vol 225 ◽  
pp. 289-297 ◽  
Author(s):  
Sara Poletti ◽  
Veronica Aggio ◽  
Silvia Brioschi ◽  
Irene Bollettini ◽  
Andrea Falini ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
Major Depressive ◽  
White Matter Microstructure

scholarly journals Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

2018 ◽  
Author(s):  
Miruna C. Barbu ◽  
Yanni Zeng ◽  
Xueyi Shen ◽  
Simon R. Cox ◽  
Toni-Kim Clarke ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
Signaling Pathway ◽  
Risk Scores ◽  
Whole Genome ◽  
Uk Biobank ◽  
Major Depressive ◽  
Polygenic Risk ◽  
White Matter Microstructure

AbstractBackgroundMajor Depressive Disorder (MDD) is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome, and growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide an important route for identification of disease mechanisms by focusing on a specific process excluding heterogeneous risk-associated variation in other pathways. Here, we sought to investigate whether MDD polygenic risk scores derived from the NETRIN1 signaling pathway (NETRIN1-PRS) and the whole genome excluding NETRIN1 pathway genes (genomic-PRS) were associated with white matter integrity.MethodsWe used two diffusion tensor imaging measures, fractional anisotropy (FA) and mean diffusivity (MD), in the most up-to-date UK Biobank neuroimaging data release (FA: N = 6,401; MD: N = 6,390).ResultsWe found significantly lower FA in the superior longitudinal fasciculus (β = -0.035, pcorrected = 0.029) and significantly higher MD in a global measure of thalamic radiations (β = 0.029, pcorrected = 0.021), as well as higher MD in the superior (β = 0.034, pcorrected = 0.039) and inferior (β = 0.029, pcorrected = 0.043) longitudinal fasciculus and in the anterior (β = 0.025, pcorrected = 0.046) and superior (β = 0.027, pcorrected = 0.043) thalamic radiation associated with NETRIN1-PRS. Genomic-PRS was also associated with lower FA and higher MD in several tracts.ConclusionsOur findings indicate that variation in the NETRIN1 signaling pathway may confer risk for MDD through effects on thalamic radiation white matter microstructure.

Major Depressive Disorder With Anger Attacks and Subcortical MRI White Matter Hyperintensities

2007 ◽  
Vol 195 (2) ◽  
pp. 175-178 ◽  
Author(s):  
Dan V. Iosifescu ◽  
Perry F. Renshaw ◽  
Darin D. Dougherty ◽  
In Kyoon Lyoo ◽  
Ho Kyu Lee ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
White Matter Hyperintensities ◽  
Major Depressive ◽  
Anger Attacks

scholarly journals Cortico-Cortical White Matter Motor Pathway Microstructure Is Related to Psychomotor Retardation in Major Depressive Disorder

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52238 ◽  
Author(s):  
Tobias Bracht ◽  
Andrea Federspiel ◽  
Susanne Schnell ◽  
Helge Horn ◽  
Oliver Höfle ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
Psychomotor Retardation ◽  
Major Depressive ◽  
Motor Pathway
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