Predictive accuracy of single- and multi-slice MRI for the estimation of total visceral adipose tissue in overweight to severely obese patients

2015 ◽  
Vol 28 (5) ◽  
pp. 583-590 ◽  
Author(s):  
Alexander Schaudinn ◽  
Nicolas Linder ◽  
Nikita Garnov ◽  
Felix Kerlikowsky ◽  
Matthias Blüher ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Predictive Accuracy ◽  
Obese Patients ◽  
Severely Obese ◽  
Visceral Adipose

Progranulin serum levels and gene expression in subcutaneous vs visceral adipose tissue of severely obese patients undergoing bariatric surgery

2019 ◽  
Vol 91 (3) ◽  
pp. 400-410 ◽  
Author(s):  
Judith Brock ◽  
Andreas Schmid ◽  
Thomas Karrasch ◽  
Petra Pfefferle ◽  
Jutta Schlegel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bariatric Surgery ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Serum Levels ◽  
Obese Patients ◽  
Severely Obese ◽  
Visceral Adipose

Changes In Body Composition And Visceral Adipose Tissue In Severely Obese Patients Following Metabolic Surgery

2014 ◽  
Vol 46 ◽  
pp. 627-628
Author(s):  
Tamara E. Carver ◽  
Robert Bracewell ◽  
Olivier Babineau ◽  
Olivier Court ◽  
Ross E. Andersen
Keyword(s):  
Body Composition ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Metabolic Surgery ◽  
Obese Patients ◽  
Severely Obese ◽  
Visceral Adipose

Precision of the iDXA for Visceral Adipose Tissue Measurement in Severely Obese Patients

2014 ◽  
Vol 46 (7) ◽  
pp. 1462-1465 ◽  
Author(s):  
TAMARA E. CARVER ◽  
OLIVIER COURT ◽  
NICOLAS V. CHRISTOU ◽  
RYAN E. R. REID ◽  
ROSS E. ANDERSEN
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Obese Patients ◽  
Severely Obese ◽  
Visceral Adipose

Overexpression of hepatic 5α-reductase and 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients

Metabolism ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 1775-1780 ◽  
Author(s):  
René Baudrand ◽  
José Miguel Domínguez ◽  
Cristian A. Carvajal ◽  
Arnoldo Riquelme ◽  
Carmen Campino ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Hydroxysteroid Dehydrogenase ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Visceral Adipose

Excess of visceral adipose tissue with or without aortic elongation leads to a steeper heart position

2021 ◽  
pp. 028418512110340
Author(s):  
S Petteri Kauhanen ◽  
Petri Saari ◽  
Tarmo Korpela ◽  
Timo Liimatainen ◽  
Ritva Vanninen ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Interquartile Range ◽  
Obese Patients ◽  
Aortic Diseases ◽  
Clinical Value ◽  
Abdominal Aortic ◽  
History Of ◽  
Axial Ct ◽  
Visceral Adipose

Background The heart’s position determined as the heart–aorta angle (HAA) has been demonstrated to associate with ascending aortic (AA) dilatation. Visceral adipose tissue (VAT) and aortic elongation may shift the heart to the steeper position. Purpose To investigate whether VAT and aortic length influence the HAA. Material and Methods We examined 346 consecutive patients (58.4% men; mean age = 67.0 ± 14.1 years) who underwent aortic computed tomography angiography (CTA). HAA was measured as the angle between the long axis of the heart and AA midline. The amount of VAT was measured at the level of middle L4 vertebra from a single axial CT slice. Aortic length was measured by combining four anatomical segments in different CTA images. The amount of VAT and aortic length were determined as mild with values in the lowest quartile and as excessive with values in the other three quartiles. Results A total of 191 patients (55.2%) had no history of aortic diseases, 134 (38.7%) displayed AA dilatation, 8 (2.3%) had abdominal aortic aneurysm (AAA), and 13 (3.8%) had both AA dilatation and AAA. There was a strong nonlinear regression between smaller HAA and VAT/height, and HAA and aortic length/height. Median HAA was 124.2° (interquartile range 119.0°–130.8°) in patients with a mild amount of VAT versus 120.5° (interquartile range 115.4°–124.7°) in patients with excessive VAT ( P < 0.001). Conclusion An excessive amount of VAT and aortic elongation led to a steeper heart position. These aspects may possess clinical value when evaluating aortic diseases in obese patients.

scholarly journals Erratum to: SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis

2010 ◽  
Vol 20 (6) ◽  
pp. 831-831
Author(s):  
Cíntia dos Santos Costa ◽  
Thais Ortiz Hammes ◽  
Francieli Rohden ◽  
Rogério Margis ◽  
Josiane Woutheres Bortolotto ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Visceral Adipose Tissue ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Visceral Adipose

scholarly journals Age and gender specific estimation of visceral adipose tissue amounts from radiological images in morbidly obese patients

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Nicolas Linder ◽  
Alexander Schaudinn ◽  
Nikita Garnov ◽  
Matthias Blüher ◽  
Arne Dietrich ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Age And Gender ◽  
Radiological Images ◽  
And Gender ◽  
Visceral Adipose ◽  
Gender Specific

scholarly journals Tumor Necrosis-Like Weak Inducer of Apoptosis as a Proinflammatory Cytokine in Human Adipocyte Cells: Up-Regulation in Severe Obesity Is Mediated by Inflammation But Not Hypoxia

2010 ◽  
Vol 24 (5) ◽  
pp. 1107-1107
Author(s):  
Joan Vendrell ◽  
Elsa Maymó-Masip ◽  
Francisco Tinahones ◽  
Antonio García-España ◽  
Ana Megia ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Er Stress ◽  
Visceral Adipose Tissue ◽  
Severe Obesity ◽  
Human Adipocyte ◽  
Severely Obese ◽  
Visceral Adipose ◽  
Type 2 Diabetic

abstract Context: Adipose tissue hypoxia and endoplasmic reticulum (ER) stress may link the presence of chronic inflammation and macrophage infiltration in severely obese subjects. We previously reported the up-regulation of TNF-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in adipose tissue of severely obese type 2 diabetic subjects. Objectives: The objective of the study was to examine TWEAK and Fn14 adipose tissue expression in obesity, severe obesity, and type 2 diabetes in relation to hypoxia and ER stress. Design: In the obesity study, 19 lean, 28 overweight, and 15 obese nondiabetic subjects were studied. In the severe obesity study, 23 severely obese and 35 control subjects were studied. In the type 2 diabetes study, 11 type 2 diabetic and 36 control subjects were studied. The expression levels of the following genes were analyzed in paired samples of sc and visceral adipose tissue: Fn14, TWEAK, VISFATIN, HYOU1, FIAF, HIF-1a, VEGF, GLUT-1, GRP78, and XBP-1. The effect of hypoxia, inflammation, and ER stress on the expression of TWEAK and Fn14 was examined in human adipocyte and macrophage cell lines. Results: Up-regulation of TWEAK/Fn14 and hypoxia and ER stress surrogate gene expression was observed in sc and visceral adipose tissue only in our severely obese cohort. Hypoxia modulates TWEAK or Fn14 expression in neither adipocytes nor macrophages. On the contrary, inflammation up-regulated TWEAK in macrophages and Fn14 expression in adipocytes. Moreover, TWEAK had a proinflammatory effect in adipocytes mediated by the nuclear factor-κB and ERK but not JNK signaling pathways. Conclusions: Our data suggest that TWEAK acts as a pro-inflammatory cytokine in the adipose tissue and that inflammation, but not hypoxia, may be behind its up-regulation in severe obesity.

Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice

2021 ◽  
Author(s):  
Mark Colin Gissler ◽  
Nathaly Anto-Michel ◽  
Jan Pennig ◽  
Philipp Scherrer ◽  
Xiaowei Li ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Obese Patients ◽  
Adipose Tissue Inflammation ◽  
Metabolic Complications ◽  
Tissue Inflammation ◽  
Diet Induced Obesity ◽  
Genetic Deficiency ◽  
Obesity In Mice ◽  
Visceral Adipose

Objective: The accumulation of inflammatory leukocytes is a prerequisite of adipose tissue inflammation during cardiometabolic disease. We previously reported that a genetic deficiency of the intracellular signaling adaptor TRAF5 (TNF [tumor necrosis factor] receptor–associated factor 5) accelerates atherosclerosis in mice by increasing inflammatory cell recruitment. Here, we tested the hypothesis that an impairment of TRAF5 signaling modulates adipose tissue inflammation and its metabolic complications in a model of diet-induced obesity in mice. Approach and Results: To induce diet-induced obesity and adipose tissue inflammation, wild-type or Traf5 −/− mice consumed a high-fat diet for 18 weeks. Traf5 −/− mice showed an increased weight gain, impaired insulin tolerance, and increased fasting blood glucose. Weight of livers and peripheral fat pads was increased in Traf5 −/− mice, whereas lean tissue weight and growth were not affected. Flow cytometry of the stromal vascular fraction of visceral adipose tissue from Traf5 −/− mice revealed an increase in cytotoxic T cells, CD11c + macrophages, and increased gene expression of proinflammatory cytokines and chemokines. At the level of cell types, expression of TNFα, MIP (macrophage inflammatory protein)-1α, MCP (monocyte chemoattractant protein)-1, and RANTES (regulated on activation, normal T-cell expressed and secreted) was significantly upregulated in Traf5 -deficient adipocytes but not in Traf5 -deficient leukocytes from visceral adipose tissue. Finally, Traf5 expression was lower in adipocytes from obese patients and mice and recovered in adipose tissue of obese patients one year after bariatric surgery. Conclusions: We show that a genetic deficiency of TRAF5 in mice diet-induced obesity and its metabolic derangements by a proinflammatory response in adipocytes. Our data indicate that TRAF5 may promote anti-inflammatory and obesity-preventing signaling events in adipose tissue.

SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis

2009 ◽  
Vol 20 (5) ◽  
pp. 633-639 ◽  
Author(s):  
Cíntia dos Santos Costa ◽  
Thais Ortiz Hammes ◽  
Francieli Rohden ◽  
Rogério Margis ◽  
Josiane Woutheres Bortolotto ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Visceral Adipose Tissue ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Visceral Adipose
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