Cerebral blood volume estimation by ferumoxytol-enhanced steady-state MRI at 9.4 T reveals microvascular impact of α1 -adrenergic receptor antibodies

2014 ◽  
Vol 27 (9) ◽  
pp. 1085-1093 ◽  
Author(s):  
Andreas Pohlmann ◽  
Peter Karczewski ◽  
Min-Chi Ku ◽  
Babette Dieringer ◽  
Helmar Waiczies ◽  
...  
Keyword(s):  
Steady State ◽  
Blood Volume ◽  
Adrenergic Receptor ◽  
Cerebral Blood Volume ◽  
Volume Estimation ◽  
Receptor Antibodies

Continuous assessment of relative cerebral blood volume in transient ischemia using steady state susceptibility-contrast MRI

1996 ◽  
Vol 35 (2) ◽  
pp. 168-173 ◽  
Author(s):  
Leena M. Hamberg ◽  
Pia Boccalini ◽  
George Stranjalis ◽  
George J. Hunter ◽  
Zhihong Huang ◽  
...  
Keyword(s):  
Steady State ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Continuous Assessment ◽  
Transient Ischemia ◽  
Relative Cerebral Blood Volume ◽  
Susceptibility Contrast

Use of time attenuation curves to determine steady-state characteristics before C-arm CT measurement of cerebral blood volume

2014 ◽  
Vol 56 (3) ◽  
pp. 245-249 ◽  
Author(s):  
Jildaz Caroff ◽  
Pakrit Jittapiromsak ◽  
Daniel Ruijters ◽  
Nidhal Benachour ◽  
Cristian Mihalea ◽  
...  
Keyword(s):  
Steady State ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Use Of Time ◽  
Ct Measurement

Technical Note: Clinical translation of the Rapid‐Steady‐State‐ T 1 MRI method for direct cerebral blood volume quantification

2015 ◽  
Vol 42 (11) ◽  
pp. 6369-6375 ◽  
Author(s):  
Teodora‐Adriana Perles‐Barbacaru ◽  
Irene Tropres ◽  
Michel G. Sarraf ◽  
David Chechin ◽  
Affif Zaccaria ◽  
...  
Keyword(s):  
Steady State ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Technical Note ◽  
Clinical Translation

scholarly journals High-Resolution Steady-State Cerebral Blood Volume Maps in Patients with Central Nervous System Neoplasms Using Ferumoxytol, a Superparamagnetic Iron Oxide Nanoparticle

2013 ◽  
Vol 33 (5) ◽  
pp. 780-786 ◽  
Author(s):  
Csanad G Varallyay ◽  
Eric Nesbit ◽  
Rongwei Fu ◽  
Seymur Gahramanov ◽  
Brendan Moloney ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Steady State ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Motion Artifacts ◽  
Iron Oxide Nanoparticle ◽  
Dynamic Susceptibility ◽  
Dynamic Susceptibility Contrast ◽  
Central Nervous System Neoplasms

Cerebral blood volume (CBV) measurement complements conventional magnetic resonance imaging (MRI) to indicate pathologies in the central nervous system (CNS). Dynamic susceptibility contrast (DSC) perfusion imaging is limited by low resolution and distortion. Steady-state (SS) imaging may provide higher resolution CBV maps but was not previously possible in patients. We tested the feasibility of clinical SS-CBV measurement using ferumoxytol, a nanoparticle blood pool contrast agent. SS-CBV measurement was analyzed at various ferumoxytol doses and compared with DSC-CBV using gadoteridol. Ninety nine two-day MRI studies were acquired in 65 patients with CNS pathologies. The SS-CBV maps showed improved contrast to noise ratios, decreased motion artifacts at increasing ferumoxytol doses. Relative CBV (rCBV) values obtained in the thalamus and tumor regions indicated good consistency between the DSC and SS techniques when the higher dose (510 mg) ferumoxytol was used. The SS-CBV maps are feasible using ferumoxytol in a clinical dose of 510 mg, providing higher resolution images with comparable rCBV values to the DSC technique. Physiologic imaging using nanoparticles will be beneficial in visualizing CNS pathologies with high vascularity that may or may not correspond with blood–brain barrier abnormalities.

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