scholarly journals Effect of taxane-based neoadjuvant chemotherapy on fibroglandular tissue volume and percent breast density in the contralateral normal breast evaluated by 3T MR

2013 ◽  
Vol 26 (12) ◽  
pp. 1705-1713 ◽  
Author(s):  
Jeon-Hor Chen ◽  
Wei-Fan Pan ◽  
Julian Kao ◽  
Jocelyn Lu ◽  
Li-Kuang Chen ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Breast Density ◽  
Normal Breast ◽  
Tissue Volume ◽  
Fibroglandular Tissue ◽  
3T Mr

scholarly journals Quantitative Measurement of Breast Density Using Personalized 3D-Printed Breast Model for Magnetic Resonance Imaging

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 793
Author(s):  
Rooa Sindi ◽  
Yin How Wong ◽  
Chai Hong Yeong ◽  
Zhonghua Sun
Keyword(s):  
Breast Density ◽  
Repeated Measures ◽  
Quantitative Measurement ◽  
Breast Volume ◽  
Tissue Volume ◽  
Fibroglandular Tissue ◽  
Quantitative Measurements ◽  
3D Printed ◽  
The Difference ◽  
Weighted Sequences

Despite the development and implementation of several MRI techniques for breast density assessments, there is no consensus on the optimal protocol in this regard. This study aimed to determine the most appropriate MRI protocols for the quantitative assessment of breast density using a personalized 3D-printed breast model. The breast model was developed using silicone and peanut oils to simulate the MRI related-characteristics of fibroglandular and adipose breast tissues, and then scanned on a 3T MRI system using non-fat-suppressed and fat-suppressed sequences. Breast volume, fibroglandular tissue volume, and percentage of breast density from these imaging sequences were objectively assessed using Analyze 14.0 software. Finally, the repeated-measures analysis of variance (ANOVA) was performed to examine the differences between the quantitative measurements of breast volume, fibroglandular tissue volume, and percentage of breast density with respect to the corresponding sequences. The volume of fibroglandular tissue and the percentage of breast density were significantly higher in the fat-suppressed sequences than in the non-fat-suppressed sequences (p < 0.05); however, the difference in breast volume was not statistically significant (p = 0.529). Further, a fat-suppressed T2-weighted with turbo inversion recovery magnitude (TIRM) imaging sequence was superior to the non-fat- and fat-suppressed T1- and T2-weighted sequences for the quantitative measurement of breast density due to its ability to represent the exact breast tissue compositions. This study shows that the fat-suppressed sequences tended to be more useful than the non-fat-suppressed sequences for the quantitative measurements of the volume of fibroglandular tissue and the percentage of breast density.

scholarly journals Decrease in Breast Density in the Contralateral Normal Breast of Patients Receiving Neoadjuvant Chemotherapy: MR Imaging Evaluation

Radiology ◽  
2010 ◽  
Vol 255 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Jeon-Hor Chen ◽  
Ke Nie ◽  
Shadfar Bahri ◽  
Chieh-Chih Hsu ◽  
Fei-Ting Hsu ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Mr Imaging ◽  
Breast Density ◽  
Normal Breast ◽  
Imaging Evaluation

scholarly journals Postmenopausal Dense Breasts Maintain Premenopausal Levels of GH and Insulin-like Growth Factor Binding Proteins in Vivo

2020 ◽  
Vol 105 (5) ◽  
pp. 1617-1628 ◽  
Author(s):  
Nina Dabrosin ◽  
Charlotta Dabrosin
Keyword(s):  
Postmenopausal Women ◽  
Breast Density ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Dense Breast ◽  
Breast Cancers ◽  
Dense Breast Tissue ◽  
Dense Breasts

Abstract Context Dense breast tissue is associated with 4 to 6 times higher risk of breast cancer by poorly understood mechanisms. No preventive therapy for this high-risk group is available. After menopause, breast density decreases due to involution of the mammary gland. In dense breast tissue, this process is haltered by undetermined biological actions. Growth hormone (GH) and insulin-like binding proteins (IGFBPs) play major roles in normal mammary gland development, but their roles in maintaining breast density are unknown. Objective To reveal in vivo levels of GH, IGFBPs, and other pro-tumorigenic proteins in the extracellular microenvironment in breast cancer, in normal breast tissue with various breast density in postmenopausal women, and premenopausal breasts. We also sought to determine possible correlations between these determinants. Setting and Design Microdialysis was used to collect extracellular in vivo proteins intratumorally from breast cancers before surgery and from normal human breast tissue from premenopausal women and postmenopausal women with mammographic dense or nondense breasts. Results Estrogen receptor positive breast cancers exhibited increased extracellular GH (P &lt; .01). Dense breasts of postmenopausal women exhibited similar levels of GH as premenopausal breasts and significantly higher levels than in nondense breasts (P &lt; .001). Similar results were found for IGFBP-1, -2, -3, and -7 (P &lt; .01) and for IGFBP-6 (P &lt;.05). Strong positive correlations were revealed between GH and IGFBPs and pro-tumorigenic matrix metalloproteinases, urokinase-type plasminogen activator, Interleukin 6, Interleukin 8, and vascular endothelial growth factor in normal breast tissue. Conclusions GH pathways may be targetable for cancer prevention therapeutics in postmenopausal women with dense breast tissue.

scholarly journals Hormonal Effects on Breast Density, Fibroglandular Tissue, and Background Parenchymal Enhancement

Radiographics ◽  
2018 ◽  
Vol 38 (4) ◽  
pp. 983-996 ◽  
Author(s):  
Samantha L. Heller ◽  
Leng Leng Young Lin ◽  
Amy N. Melsaether ◽  
Linda Moy ◽  
Yiming Gao
Keyword(s):  
Breast Density ◽  
Hormonal Effects ◽  
Fibroglandular Tissue ◽  
Background Parenchymal Enhancement ◽  
Parenchymal Enhancement
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