scholarly journals Noninvasive functional imaging of cerebral blood volume with vascular-space-occupancy (VASO) MRI

2013 ◽  
Vol 26 (8) ◽  
pp. 932-948 ◽  
Author(s):  
Hanzhang Lu ◽  
Jun Hua ◽  
Peter C. M. van Zijl
Keyword(s):  
Blood Volume ◽  
Functional Imaging ◽  
Cerebral Blood Volume ◽  
Vascular Space

scholarly journals On the measurement of absolute cerebral blood volume (CBV) using vascular-space-occupancy (VASO) MRI

2008 ◽  
Vol 61 (3) ◽  
pp. 659-667 ◽  
Author(s):  
Jinsoo Uh ◽  
Kelly Lewis-Amezcua ◽  
Rani Varghese ◽  
Hanzhang Lu
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Vascular Space

Noninvasive imaging of cerebral blood volume in piglets with vascular occupancy MR imaging and inflow vascular space occupancy with dynamic subtraction

2018 ◽  
Vol 50 ◽  
pp. 54-60
Author(s):  
Benjamin J. Zimmerman ◽  
Austin T. Mudd ◽  
Joanne E. Fil ◽  
Ryan N. Dilger ◽  
Bradley P. Sutton
Keyword(s):  
Mr Imaging ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Noninvasive Imaging ◽  
Vascular Space

scholarly journals Detecting resting-state brain activity by spontaneous cerebral blood volume fluctuations using whole brain vascular space occupancy imaging

NeuroImage ◽  
2014 ◽  
Vol 84 ◽  
pp. 575-584 ◽  
Author(s):  
Xinyuan Miao ◽  
Hong Gu ◽  
Lirong Yan ◽  
Hanzhang Lu ◽  
Danny J.J. Wang ◽  
...  
Keyword(s):  
Blood Volume ◽  
Resting State ◽  
Cerebral Blood Volume ◽  
Brain Activity ◽  
Whole Brain ◽  
Vascular Space ◽  
Volume Fluctuations

scholarly journals Vascular space occupancy (VASO) cerebral blood volume-weighted MRI identifies hemodynamic impairment in patients with carotid artery disease

2009 ◽  
Vol 29 (3) ◽  
pp. 718-724 ◽  
Author(s):  
Manus J. Donahue ◽  
Peter Jan van Laar ◽  
Peter C.M. van Zijl ◽  
Robert D. Stevens ◽  
Jeroen Hendrikse
Keyword(s):  
Carotid Artery ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Carotid Artery Disease ◽  
Vascular Space ◽  
Hemodynamic Impairment ◽  
Artery Disease

Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation

1998 ◽  
Vol 39 (4) ◽  
pp. 615-624 ◽  
Author(s):  
Joseph B. Mandeville ◽  
John J. A. Marota ◽  
Barry E. Kosofsky ◽  
John R. Keltner ◽  
Ralph Weissleder ◽  
...  
Keyword(s):  
Blood Volume ◽  
Functional Imaging ◽  
Cerebral Blood Volume ◽  
Relative Cerebral Blood Volume

scholarly journals Estimating cerebral blood volume with expanded vascular space occupancy slice coverage

2009 ◽  
Vol 61 (5) ◽  
pp. 1193-1200 ◽  
Author(s):  
Christopher B. Glielmi ◽  
Ronald A. Schuchard ◽  
X.P. Hu
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Vascular Space

scholarly journals Absolute Arterial Cerebral Blood Volume Quantification Using Inflow Vascular-Space-Occupancy with Dynamic Subtraction Magnetic Resonance Imaging

2010 ◽  
Vol 30 (7) ◽  
pp. 1329-1342 ◽  
Author(s):  
Manus J Donahue ◽  
Ediri Sideso ◽  
Bradley J MacIntosh ◽  
James Kennedy ◽  
Ashok Handa ◽  
...  
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Dynamic Susceptibility ◽  
Dynamic Susceptibility Contrast ◽  
Industry Standard ◽  
Vascular Space ◽  
Water Signal ◽  
Contrast Mechanism ◽  
The Difference ◽  
Susceptibility Contrast

In patients with steno-occlusive disease of the internal carotid artery (ICA), cerebral blood flow may be maintained by autoregulatory increases in arterial cerebral blood volume (aCBV). Therefore, characterizing aCBV may be useful for understanding hemodynamic compensation strategies. A new ‘inflow vascular-space-occupancy with dynamic subtraction (iVASO-DS)’ MRI approach is presented where aCBV (mL blood/100 mL parenchyma) is quantified without contrast agents using the difference between images with and without inflowing blood water signal. The iVASO-DS contrast mechanism is investigated (3.0 T, spatial resolution=2.4 × 2.4 × 5 mm3) in healthy volunteers ( n=8; age=29±5 years), and patients with mild ( n=7; age=72±8 years) and severe ( n=10; age=73±8 years) ICA stenoses. aCBV was quantified in right and left hemispheres in controls, and, alongside industry standard dynamic susceptibility contrast (DSC), contralateral (cont), and ipsilateral (ips) to maximum stenosis in patients. iVASO contrast significantly correlated ( R=0.67, P<0.01) with DSC-CBV after accounting for transit time discrepancies. Gray matter aCBV (mL/100 mL) was 1.60±0.10 (right) versus 1.61±0.20 (left) in controls, 1.59±0.38 (cont) and 1.65±0.37 (ips) in mild stenosis patients, and 1.72±0.18 (cont) and 1.58±0.20 (ips) in severe stenosis patients. aCBV was asymmetric ( P<0.01) in 41% of patients whereas no asymmetry was found in any control. The potential of iVASO-DS for autoregulation studies is discussed in the context of existing hemodynamic literature.

scholarly journals Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imaging

2005 ◽  
Vol 54 (6) ◽  
pp. 1403-1411 ◽  
Author(s):  
Hanzhang Lu ◽  
Meng Law ◽  
Glyn Johnson ◽  
Yulin Ge ◽  
Peter C. M. van Zijl ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Resonance Imaging ◽  
Vascular Space ◽  
Novel Approach

scholarly journals Striatal and Cortical BOLD, Blood Flow, Blood Volume, Oxygen Consumption, and Glucose Consumption Changes in Noxious Forepaw Electrical Stimulation

2010 ◽  
Vol 31 (3) ◽  
pp. 832-841 ◽  
Author(s):  
Yen-Yu I Shih ◽  
Hsiao-Ying Wey ◽  
Bryan H De La Garza ◽  
Timothy Q Duong
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Blood Volume ◽  
Functional Imaging ◽  
Cerebral Blood Volume ◽  
Glucose Consumption ◽  
Blood Oxygenation ◽  
Cerebral Metabolic Rate ◽  
Positron Emission

Recent reports showed noxious forepaw stimulation in rats evoked an unexpected sustained decrease in cerebral blood volume (CBV) in the bilateral striatum, whereas increases in spike activity and Fos-immunoreactive cells were observed. This study aimed to further evaluate the hemodynamic and metabolic needs in this model and the sources of negative functional magnetic resonance imaging (fMRI) signals by measuring blood oxygenation-level-dependent (BOLD), cerebral-blood-flow (CBF), CBV, and oxygen-consumption (i.e., cerebral metabolic rate of oxygen (CMRO2)) changes using an 11.7-T MRI scanner, and glucose-consumption (i.e., cerebral metabolic rate of glucose (CMRglc)) changes using micro-positron emission tomography. In the contralateral somatosensory cortex, BOLD, CBF, CBV, CMRO2 ( n=7, P<0.05), and CMRglc ( n=5, P<0.05) increased. In contrast, in the bilateral striatum, BOLD, CBF, and CBV decreased ( P<0.05), CMRO2 decreased slightly, although not significantly from baseline, and CMRglc was not statistically significant from baseline ( P>0.05). These multimodal functional imaging findings corroborate the unexpected negative hemodynamic changes in the striatum during noxious forepaw stimulation, and support the hypothesis that striatal hemodynamic response is dominated by neurotransmitter-mediated vasoconstriction, overriding the stimulus-evoked fMRI signal increases commonly accompany elevated neuronal activity. Multimodal functional imaging approach offers a means to probe the unique attributes of the striatum, providing novel insights into the neurovascular coupling in the striatum. These findings may have strong implications in fMRI studies of pain.

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