Magnetic resonance spectroscopy shows an inverse correlation between intramyocellular lipid content in human calf muscle and local glycogen synthesis rate

2009 ◽  
pp. n/a-n/a ◽  
Author(s):  
Marinette van der Graaf ◽  
Cees J. Tack ◽  
Jacco H. de Haan ◽  
Dennis W. J. Klomp ◽  
Arend Heerschap
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Glycogen Synthesis ◽  
Inverse Correlation ◽  
Synthesis Rate ◽  
Resonance Spectroscopy ◽  
Intramyocellular Lipid ◽  
Intramyocellular Lipid Content ◽  
Human Calf ◽  
Glycogen Synthesis Rate

scholarly journals Assessment of Rapid Hepatic Glycogen Synthesis in Humans Using Dynamic 13 C Magnetic Resonance Spectroscopy

2020 ◽  
Vol 4 (3) ◽  
pp. 425-433
Author(s):  
Stefan Stender ◽  
Vlad G. Zaha ◽  
Craig R. Malloy ◽  
Jessica Sudderth ◽  
Ralph J. DeBerardinis ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Glycogen Synthesis ◽  
Hepatic Glycogen ◽  
Resonance Spectroscopy

scholarly journals Magnetic resonance spectroscopy analysis of intramyocellular lipid composition in lipodystrophic patients and athletes

2018 ◽  
Author(s):  
David B Savage ◽  
Laura Watson ◽  
Katie Carr ◽  
Claire Adams ◽  
Soren Brage ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Tibialis Anterior ◽  
Saturation Index ◽  
Resonance Spectroscopy ◽  
Intramyocellular Lipid ◽  
Age And Gender ◽  
Insulin Resistant ◽  
And Gender

AbstractContextParadoxically, intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and to insulin-sensitive (athletes) states. The composition of this lipid store is unknown in these states.Design and MethodsWe used a recently validated and potentially widely applicable 1H magnetic resonance spectroscopy method to compare the compositional saturation index (CH2:CH3 ratio) and concentration independent of composition (CH3) of intramyocellular lipid in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic patients with that of age- and gender-matched athletes (n=14) and healthy controls (n = 41).Main OutcomeIMCL compositional saturation index (CH2:CH3 ratio).ResultsThe IMCL CH2:CH3 ratio was significantly higher in both muscles of the lipodystrophic patients compared with age- and gender-matched controls but not compared to athletes. IMCL CH2:CH3 was dependent on IMCL concentration in the controls and after adjusting the composition index for quantity (CH2:CH3adj) was able to distinguish patients from athletes. With groups pooled, this CH2:CH3adj marker had the strongest relation to insulin resistance (HOMA-IR) compared to other measures of lipid concentration and composition, especially in the soleus muscle. Contrary to the ‘athlete’s paradox’, IMCL in athletes was similar in tibialis anterior (p>0.05) and significantly lower in the soleus (p < 0.004) compared to both controls and patients.ConclusionsThe IMCL saturation index adjusted for quantity, which likely reflects accumulation of saturated IMCL, is more closely associated with insulin resistance than concentration alone.

scholarly journals Changes in Energy Metabolism of Calf Muscle in Patients with Intermittent Claudication Assessed by 31P Magnetic Resonance Spectroscopy: A Phase II Open Study

1996 ◽  
Vol 1 (4) ◽  
pp. 241-245 ◽  
Author(s):  
DJ Taylor ◽  
A Amato ◽  
LJ Hands ◽  
GJ Kemp ◽  
G Ramaswami ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Intermittent Claudication ◽  
Muscle Metabolism ◽  
Inverse Correlation ◽  
Arterial Disease ◽  
Walking Distance ◽  
Resonance Spectroscopy ◽  
Energy Status ◽  
Peripheral Arterial

Energy status and metabolism in skeletal muscle of nine patients with peripheral arterial disease and suffering from intermittent claudication were evaluated using 31phosphorus magnetic resonance spectroscopy (MRS) before and after treatment for 3 months with propionyl-L-carnitine (PLC; 2 g/day p.o.). Maximum walking distance (MWD) was assessed on a standard treadmill (4 km/h, zero incline). For the group as a whole 31P MRS results did not change significantly with PLC. Although MWD increased by a mean of 36%, this change did not reach significance. However, when these variables were assessed with respect to the change in MWD, there were significant differences between those who increased MWD by > 30% (responders, R; n = 5) and those who did not (nonresponders, NR; n = 4). Compared with pretreatment values, during exercise the decrease in muscle pH in R relative to the decrease in phosphocreatine was less after PLC ( p = 0.04). After exercise there was a significant inverse correlation between the changes in recovery half-time ( t½) for phosphocreatine and in MWD ( r=−0.91, p = 0.01). With PLC, Vmax increased in R ( p = 0.04), but not in NR. For the patient group as a whole, the changes in Vmax and MWD correlated positively ( r = 0.90, p = 0.01). This study helps to identify the changes in muscle metabolism that correlate with changes in exercise performance, and may accompany treatment with PLC.

Magnetic Resonance Spectroscopy Facilitates Assessment of Intramyocellular Lipid Changes: a Preliminary Short-Term Study Following Biliopancreatic Diversion

2005 ◽  
Vol 15 (9) ◽  
pp. 1233-1237 ◽  
Author(s):  
Gian Franco Adami ◽  
Roberto Carlo Parodi ◽  
Francesco Papadia ◽  
Giuseppe Marinari ◽  
Giovanni Camerini ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Biliopancreatic Diversion ◽  
Resonance Spectroscopy ◽  
Intramyocellular Lipid ◽  
Short Term ◽  
Term Study ◽  
Short Term Study
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