Histologic and physiologic analysis of the relationship between the dorsal nerve of the penis and the corpus cavernosum on a rat model. A complementary pathway on the innervation of penile erection?

2021 ◽  
Author(s):  
Zafer Kozacioglu ◽  
H. Seda Vatansever ◽  
Tuna Onal ◽  
Necip Kutlu ◽  
Fehmi Ozel ◽  
...  
Keyword(s):  
Rat Model ◽  
Penile Erection ◽  
Corpus Cavernosum ◽  
Dorsal Nerve ◽  
The Relationship

scholarly journals The effect of mirodenafil on the penile erection and corpus cavernosum in the rat model of cavernosal nerve injury

2010 ◽  
Vol 22 (5) ◽  
pp. 291-297 ◽  
Author(s):  
H Kim ◽  
D W Sohn ◽  
S D Kim ◽  
S-H Hong ◽  
H J Suh ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Rat Model ◽  
Penile Erection ◽  
Corpus Cavernosum ◽  
Cavernosal Nerve

The Effect of Cyanidin-3-O-β-d-glucopyranoside on the Penile Erection and Corpus Cavernosum in a Rat Model of Diabetic Erectile Dysfunction

2011 ◽  
Vol 29 (2) ◽  
pp. 127
Author(s):  
U Syn Ha ◽  
Joon Sung Koh ◽  
Jang Chun Woo ◽  
Suk Ju Kim ◽  
Su Jin Kim ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Rat Model ◽  
Penile Erection ◽  
Corpus Cavernosum

scholarly journals A Case of Priapism with Risperidone

2014 ◽  
Vol 2014 ◽  
pp. 1-2 ◽  
Author(s):  
Almari Ginory ◽  
Mathew Nguyen
Keyword(s):  
Side Effect ◽  
Penile Erection ◽  
Corpus Cavernosum ◽  
Psychotropic Medications ◽  
History Of ◽  
Future Risk ◽  
New Onset

Priapism is a urologic emergency defined as a prolonged, possibly painful, penile erection. There are several known causes of priapism including psychotropic medications. One of the mechanisms by which antipsychotics are believed to induce priapism is through alpha-1 antagonism. This is case of a 50-year-old male with a history of schizophrenia with previous priapism related to trazodone, who presents with new onset priapism associated with risperidone. In this case, the treatment of priapism includes discontinuation of the offending agent and drainage of the corpus cavernosum twice along with intracavernosal phenylephrine injections. It is important to educate patients on priapism as a possible side effect of medications. It is also important to consider previous episodes of medication-induced priapism when prescribing psychotropic medications as this may increase the patient’s future risk of priapism.

The Relationship Between N-acetylcysteine, Hyperbaric Oxygen, and Inflammation in a Rat Model of Acetaminophen-induced Nephrotoxicity

Inflammation ◽  
2013 ◽  
Vol 36 (5) ◽  
pp. 1145-1152 ◽  
Author(s):  
Hakan Cermik ◽  
Mine Yavuz Taslipinar ◽  
Ibrahim Aydin ◽  
Mehmet Agilli ◽  
Fevzi Nuri Aydin ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Rat Model ◽  
The Relationship

Intake of Anti-Epileptic Drugs and their Influences on Sexual Dysfunctions

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Roheela Yasmeen ◽  
Nida Mobeen ◽  
Muhammad Amjad Khan ◽  
Irfan Aslam ◽  
Samia Chaudhry
Keyword(s):  
Quality Of Life ◽  
Sexual Dysfunction ◽  
Neurological Disorders ◽  
Penile Erection ◽  
The Central Nervous System ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain ◽  
Psychiatric Problems

Epilepsy which is also called seizures disorder is an uncontrolled action of the central nervous system. Itis not a single disease but a set of neurological disorders. Actually in this situation, the brain does notreceive a precise signal and as a result an abnormal condition is produced that is usually involuntary inaction. In this review, we aimed to focus on the relationship of anti-epileptic drugs with sexual dysfunctionand adaptation of better remedies that improve a patient’s family life. Sexual dysfunction is a commoncomorbidity in people with epilepsy which badly affects their quality of life. Sexual dysfunction is causedby different factors like psychiatric problems, anti-epileptic drugs (AEDs) and social factors etc. Sexualdysfunctions include ejaculatory failure, lessen libido, penile erection in men and irregular menstrual cyclein women. Common drugs such as Topiramate, Gabapentin (GBP), Valproate (VA), Carbamazepine (CBZ),Olanzapine (OL) and Risperidone (RTG) that are in practice to treat epilepsy usually produced adverseeffect on sexual dysfunction. Even though a lot of studies have been carried out to control sexualdysfunction in epilepsy’s patient, but still research is going on. Medicine such as Cyproheptadine,Mianserin, Buspirone, Yohimbine were found better to treat epilepsy with minimum side effects of sexualdysfunction. Moreover, it is also seen that certain vasodilators, folate , and vitamin supplements areeffective in improving the quality of life.

The Effects of New Herbal Formula (KBMSI-1) on the Penile Erection and Corpus Cavernosum in Streptozotocin-induced Diabetic Rats

2011 ◽  
Vol 29 (2) ◽  
pp. 144 ◽  
Author(s):  
Byung Il Yoon ◽  
Tae Seung Shin ◽  
Jang Chun Woo ◽  
Su Jin Kim ◽  
Hyo Sin Kim ◽  
...  
Keyword(s):  
Penile Erection ◽  
Corpus Cavernosum ◽  
Diabetic Rats ◽  
Herbal Formula

Rat Model for the Study of Penile Erection: Pharmacologic and Electrical-Stimulation Parameters

1994 ◽  
Vol 25 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Luis Martinez-Piñerio ◽  
Gerald Brock ◽  
Flavio Trigo-Rocha ◽  
Geng Hsu ◽  
Tom F. Lue ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Rat Model ◽  
Penile Erection ◽  
Stimulation Parameters

Ca2+-activated Cl− channels in corpus cavernosum smooth muscle: a novel mechanism for control of penile erection

2003 ◽  
Vol 94 (1) ◽  
pp. 301-313 ◽  
Author(s):  
Tom Karkanis ◽  
Ling DeYoung ◽  
Gerald B. Brock ◽  
Stephen M. Sims
Keyword(s):  
Smooth Muscle ◽  
Penile Erection ◽  
Corpus Cavernosum ◽  
Outward Current ◽  
Channel Blockers ◽  
Inward Current ◽  
Inward Currents ◽  
Cl Channels ◽  
Patch Clamp Electrophysiology

Little is known of the excitatory mechanisms that contribute to the tonic contraction of the corpus cavernosum smooth muscle in the flaccid state. We used patch-clamp electrophysiology to investigate a previously unidentified inward current in freshly isolated rat and human corporal myocytes. Phenylephrine (PE) contracted cells and activated whole cell currents. Outward current was identified as large-conductance Ca2+-activated K+ current. The inward current elicited by PE was dependent on the Cl− gradient and was inhibited by niflumic acid, indicative of a Ca2+-activated Cl− (ClCa) current. Furthermore, spontaneous transient outward and inward currents (STOCs and STICs, respectively) were identified in both rat and human corporal myocytes and derived from large-conductance Ca2+-activated K+ and ClCa channel activity. STICs and STOCs were inhibited by PE and A-23187, and combined 8-bromoadenosine cAMP and 8-bromoadenosine cGMP decreased their frequency. When studied in vivo, chloride channel blockers transiently increased intracavernosal pressure and prolonged nerve-evoked erections. This report reveals for the first time ClCa current in rat and human corpus cavernosum smooth muscle cells and demonstrates its key functional role in the regulation of penile erection.

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