Low‐pressure hydrodistension induces bladder glomerulations in female patients with interstitial cystitis/bladder pain syndrome

2021 ◽  
Author(s):  
Lin‐Nei Hsu ◽  
Yuh‐Shyan Tsai ◽  
Yat‐Ching Tong
Keyword(s):  
Interstitial Cystitis ◽  
Pain Syndrome ◽  
Low Pressure ◽  
Bladder Pain Syndrome ◽  
Bladder Pain ◽  
Female Patients

scholarly journals Differential expression of histamine receptors in the bladder wall tissues of patients with bladder pain syndrome/interstitial cystitis – significance in the responsiveness to antihistamine treatment and disease symptoms

BMC Urology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hui Shan ◽  
Er-Wei Zhang ◽  
Peng Zhang ◽  
Xiao-Dong Zhang ◽  
Ning Zhang ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Western Blotting ◽  
Bladder Wall ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Histamine Receptors ◽  
Receptor Expression ◽  
Bladder Pain ◽  
Disease Symptoms ◽  
Female Patients

Abstract Background Activation of mast cells plays an important role in the pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC). Histamine, a mast cell-derived mediators, induced inflammation and hypersensitivity of the bladder. The present study investigated the expressions of histamine receptors in the bladder wall tissues of patients with BPS/IC, and its association with the effectiveness of antihistamine therapy and disease symptoms. Methods Bladder tissues were collected from 69 BPS/IC patients and 10 control female patients. The expression of H3R in BPS/IC was further examined in an independent cohort of 10 female patients with BPS/IC and another 10 age-matched female patients. Immunohistochemistry, Western blotting, and quantitative RT-PCR were performed to quantify the expressions of histamine receptors. Statistical analyses of the correlation of histamine receptor expression with antihistamine therapy outcome and severity of disease symptoms were also performed. Results The expression of four histamine receptors was significantly elevated in BPS/IC (H1R, P < 0.001; H2R, P = 0.031; H3R, P = 0.008; H4R, P = 0.048). Western blotting revealed that H3R were significantly reduced in the patients, whereas the mRNA levels of H3R were significantly increased. The patients were further divided into antihistamine responders (n = 38) and nonresponders (n = 22). No significant correlation was found in the expression of histamine receptors between responder and nonresponder groups. However, significant correlations between OLS and H1R (P = 0.003) and H3R (P = 0.045) were found. Conclusion The present study showed that expression of all the 4 histamine receptors were elevated in BPS/IC. There were no statistical significant correlations between the expression levels of the four different histamine receptors and the treatment outcome of antihistamine therapy (amtitriptyline or cimetidine).

Mapping of Pain Phenotypes in Female Patients with Bladder Pain Syndrome/Interstitial Cystitis and Controls

2012 ◽  
Vol 62 (6) ◽  
pp. 1188-1194 ◽  
Author(s):  
Dean A. Tripp ◽  
J. Curtis Nickel ◽  
Jennifer Wong ◽  
Michel Pontari ◽  
Robert Moldwin ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Bladder Pain ◽  
Female Patients
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