Effects of a new β3‐adrenoceptor agonist, vibegron, on neurogenic bladder dysfunction and remodeling in mice with spinal cord injury

2020 ◽  
Vol 39 (8) ◽  
pp. 2120-2127
Author(s):  
Daisuke Gotoh ◽  
Nobutaka Shimizu ◽  
Naoki Wada ◽  
Katsumi Kadekawa ◽  
Tetsuichi Saito ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurogenic Bladder ◽  
Bladder Dysfunction ◽  
Neurogenic Bladder Dysfunction ◽  
Adrenoceptor Agonist ◽  
Cord Injury

scholarly journals Efficacy of biofeedback, repetitive transcranial magnetic stimulation and pelvic floor muscle training for female neurogenic bladder dysfunction after spinal cord injury: a study protocol for a randomised controlled trial

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e034582
Author(s):  
Lin Xu ◽  
Chenying Fu ◽  
Qing Zhang ◽  
Feng Xiong ◽  
Lihong Peng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pelvic Floor ◽  
Neurogenic Bladder ◽  
Bladder Dysfunction ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Pelvic Floor Muscle ◽  
Controlled Trial ◽  
Neurogenic Bladder Dysfunction ◽  
Cord Injury

IntroductionNeurogenic bladder dysfunction is prevalent in female patients with spinal cord injury (SCI), and previous guidelines have recommended pelvic floor muscle training (PFMT) for first-line conservative treatment. However, the actual regimen of PFMT varies widely and the single treatment does not satisfy the need of some patients. Therefore, this study aims to provide a detailed rationale and methodology for comparing the effectiveness of PFMT, biofeedback and repetitive transcranial magnetic stimulation (rTMS) as adjunct treatments for neurogenic bladder dysfunction.Methods and analysisThis trial is a single-centre randomised controlled trial for female patients with urinary incontinence (UI) in phase of chronic SCI. Eligible participants will be randomised to one of four arms: (1) PFMT, (2) PFMT with biofeedback, (3) PFMT and rTMS and (4) PFMT with biofeedback and rTMS. There will be 44 participants in each arm and all the subjects will undergo 20 treatment sessions, five times a week for 4 weeks. The outcomes will be evaluated at 4 weeks, 3 months and 6 months after randomisation. The primary outcome is the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form, and the secondary outcomes include bladder diary, pelvic floor muscle function and the International Spinal Cord Injury Quality of Life Basic Data Set.Ethics and disseminationThe Clinical Research and Biomedical Ethics Committee of the West China Hospital, Sichuan University has approved this trial and the approval number is 2019-885. All participants will be provided written informed consent after verification of the eligibility criteria. The results of this study will be accessible in peer-reviewed publications and be presented at academic conferences.Trial registration numberChinese Clinical Trial Registry (ChiCTR1900026126).

scholarly journals The treatment of neurogenic bladder dysfunction in patients with spinal cord injury

2013 ◽  
Vol 10 (4) ◽  
pp. 157-165
Author(s):  
Natasa Markovic ◽  
Miodrag Veljkovic ◽  
Tanja Zecevic-Lukovic
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurogenic Bladder ◽  
Bladder Dysfunction ◽  
Neurogenic Bladder Dysfunction ◽  
Cord Injury

scholarly journals Results of the Treatment of Neurogenic Bladder Dysfunction in Spinal Cord Injury by Sacral Posterior Root Rhizotomy and Anterior Sacral Root Stimulation

1996 ◽  
Vol 155 (4) ◽  
pp. 1378-1381 ◽  
Author(s):  
Philip E.V. Van Kerrebroeck ◽  
Evert L. Koldewijn ◽  
Peter F.W.M. Rosier ◽  
Hessel Wijkstra ◽  
Frans M.J. Debruyne
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurogenic Bladder ◽  
Bladder Dysfunction ◽  
Posterior Root ◽  
Neurogenic Bladder Dysfunction ◽  
Cord Injury ◽  
Root Stimulation

Reconstructed bladder innervation above the level of spinal cord injury to produce urination by abdomen-to-bladder reflex contractions

2011 ◽  
Vol 14 (6) ◽  
pp. 799-802 ◽  
Author(s):  
Haodong Lin ◽  
Chunlin Hou ◽  
Aimin Chen
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurogenic Bladder ◽  
Treatment Strategy ◽  
Social Problem ◽  
Bladder Dysfunction ◽  
Conus Medullaris ◽  
Neurogenic Bladder Dysfunction ◽  
Reflex Pathway ◽  
Cord Injury

Neurogenic bladder dysfunction following spinal cord injury is a major medical and social problem for which there is no ideal treatment strategy. This paper describes the authors' attempts to establish bladder reinnervation, by establishing an abdomen-to-bladder reflex pathway, in a patient with an injury to the conus medullaris.

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