scholarly journals Prevalence, subtypes, and correlates of nocturia in the symptoms of Lower Urinary Tract Dysfunction Research Network cohort

2020 ◽  
Vol 39 (4) ◽  
pp. 1098-1107 ◽  
Author(s):  
J. Quentin Clemens ◽  
Jonathan B. Wiseman ◽  
Abigail R. Smith ◽  
Cindy L. Amundsen ◽  
Claire C. Yang ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Research Network ◽  
Lower Urinary Tract Dysfunction ◽  
Lower Urinary

scholarly journals A new outcome measure for LUTS: Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index‐29 (LURN SI‐29) questionnaire

2019 ◽  
Vol 38 (6) ◽  
pp. 1751-1759
Author(s):  
David Cella ◽  
Abigail R. Smith ◽  
James W. Griffith ◽  
Kathryn E. Flynn ◽  
Catherine S. Bradley ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Outcome Measure ◽  
Research Network ◽  
Lower Urinary Tract Dysfunction ◽  
Symptom Index ◽  
Lower Urinary

scholarly journals Are three‐day voiding diaries feasible and reliable? Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) cohort

2019 ◽  
Vol 38 (8) ◽  
pp. 2185-2193 ◽  
Author(s):  
Anne P. Cameron ◽  
Jonathan B. Wiseman ◽  
Abigail R. Smith ◽  
Robert M. Merion ◽  
Brenda W. Gillespie ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Research Network ◽  
Lower Urinary Tract Dysfunction ◽  
Lower Urinary

scholarly journals PD50-04 SYMPTOM-BASED CLUSTERING OF FEMALE LUTS PARTICIPANTS IN THE SYMPTOMS OF LOWER URINARY TRACT DYSFUNCTION RESEARCH NETWORK (LURN) STUDY

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Victor P. Andreev ◽  
Gang Liu PhD ◽  
Claire C. Yang MD ◽  
Abigail R. Smith PhD ◽  
Margaret E. Helmuth MA ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Research Network ◽  
Lower Urinary Tract Dysfunction ◽  
Lower Urinary

scholarly journals Symptoms of Lower Urinary Tract Dysfunction Research Network

2016 ◽  
Vol 196 (1) ◽  
pp. 146-152 ◽  
Author(s):  
Claire C. Yang ◽  
Kevin P. Weinfurt ◽  
Robert M. Merion ◽  
Ziya Kirkali ◽  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Research Network ◽  
Lower Urinary Tract Dysfunction ◽  
Lower Urinary

scholarly journals Subtyping of common complex diseases and disorders by integrating heterogeneous data. Identifying clusters among women with lower urinary tract symptoms in the LURN study

2021 ◽  
Author(s):  
Victor P. Andreev ◽  
Margaret E. Helmuth ◽  
Gang Liu ◽  
Abigail R. Smith ◽  
Robert M. Merion ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Heterogeneous Data ◽  
Research Network ◽  
Lower Urinary Tract Dysfunction ◽  
Multidimensional Data ◽  
Data Types ◽  
Urinary Tract Symptoms ◽  
Lower Urinary

ABSTRACTWe present a novel methodology for subtyping of persons with a common clinical symptom complex by integrating heterogeneous continuous and categorical data. We illustrate it by clustering women with lower urinary tract symptoms (LUTS), who represent a heterogeneous cohort with overlapping symptoms and multifactorial etiology. Identifying subtypes within this group would potentially lead to better diagnosis and treatment decision-making. Data collected in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN), a multi-center prospective observational cohort study, included self-reported urinary and non-urinary symptoms, bladder diaries, and physical examination data for 545 women. Heterogeneity in these multidimensional data required thorough and non-trivial preprocessing, including scaling by controls and weighting to mitigate data redundancy, while the various data types (continuous and categorical) required novel methodology using a weighted Tanimoto indices approach. Data domains only available on a subset of the cohort were integrated using a semi-supervised clustering approach. Novel contrast criterion for determination of the optimal number of clusters in consensus clustering was introduced and compared with existing criteria. Distinctiveness of the clusters was confirmed by using multiple criteria for cluster quality, and by testing for significantly different variables in pairwise comparisons of the clusters. Cluster dynamics were explored by analyzing longitudinal data at 3- and 12-month follow-up. Five distinct clusters of women with LUTS were identified using the developed methodology. The clinical relevance of the identified clusters is discussed and compared with the current conventional approaches to the evaluation of LUTS patients. Rationale and thought process are described for selection of procedures for data preprocessing, clustering, and cluster evaluation. Suggestions are provided for minimum reporting requirements in publications utilizing clustering methodology with multiple heterogeneous data domains.

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