Increased autophagy contributes to impaired smooth muscle function in neurogenic lower urinary tract dysfunction

2018 ◽  
Vol 37 (8) ◽  
pp. 2414-2424
Author(s):  
Daniel Eberli ◽  
Maya Horst ◽  
Ashkan Mortezavi ◽  
Karl-Erik Andersson ◽  
Rita Gobet ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Urinary Tract ◽  
Muscle Function ◽  
Lower Urinary Tract ◽  
Lower Urinary Tract Dysfunction ◽  
Smooth Muscle Function ◽  
Lower Urinary

scholarly journals Contractile and Structural Properties of Detrusor from Children with Neurogenic Lower Urinary Tract Dysfunction

Biology ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 863
Author(s):  
Navroop Johal ◽  
Kevin X. Cao ◽  
Boyu Xie ◽  
Michael Millar ◽  
Reena Davda ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Urinary Tract ◽  
Connective Tissue ◽  
Lower Urinary Tract ◽  
Wnt Signalling ◽  
Lower Urinary Tract Dysfunction ◽  
Signalling Pathways ◽  
Foetal Development ◽  
Lower Urinary

Neurogenic lower urinary tract (NLUT) dysfunction in paediatric patients can arise after congenital or acquired conditions that affect bladder innervation. With some patients, urinary tract dysfunction remains and is more difficult to treat without understanding the pathophysiology. We measured in vitro detrusor smooth muscle function of samples from such bladders and any association with altered Wnt-signalling pathways that contribute to both foetal development and connective tissue deposition. A comparator group was tissue from children with normally functioning bladders. Nerve-mediated and agonist-induced contractile responses and passive stiffness were measured. Histology measured smooth muscle and connective tissue proportions, and multiplex immunohistochemistry recorded expression of protein targets associated with Wnt-signalling pathways. Detrusor from the NLUT group had reduced contractility and greater stiffness, associated with increased connective tissue content. Immunohistochemistry showed no major changes to Wnt-signalling components except down-regulation of c-Myc, a multifunctional regulator of gene transcription. NLUT is a diverse term for several diagnoses that disrupt bladder innervation. While we cannot speculate about the reasons for these pathophysiological changes, their recognition should guide research to understand their ultimate causes and develop strategies to attenuate and even reverse them. The role of changes to the Wnt-signalling pathways was minor.

Sign in / Sign up

Export Citation Format

Share Document