Therapeutic effect of TAC-302, a cyclohexenoic fatty alcohol derivative, on bladder denervation-related storage and voiding dysfunctions in rats

2018 ◽  
Vol 37 (7) ◽  
pp. 2106-2113 ◽  
Author(s):  
Shohei Yoshida ◽  
Takahisa Noma ◽  
Kazuhisa Miyoshi ◽  
Hiroshi Tsukihara ◽  
Naoki Orimoto ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Fatty Alcohol ◽  
Voiding Dysfunctions ◽  
Alcohol Derivative

Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

1994 ◽  
Vol 71 (06) ◽  
pp. 768-772 ◽  
Author(s):  
Gerhard Dickneite ◽  
Jörg Czech
Keyword(s):  
Septic Shock ◽  
Klebsiella Pneumoniae ◽  
Organ Failure ◽  
Therapeutic Effect ◽  
Disseminated Intravascular Coagulation ◽  
Post Infection ◽  
Thrombin Inhibitor ◽  
Bolus Administration ◽  
Bacterial Burden ◽  
Recombinant Hirudin

SummaryRats which were infected with the gramnegative pathogen Klebsiella pneumoniae develop disseminated intravascular coagulation (DIC), multi-organ failure (MOF) and finally die in a septic shock. We investigated the therapeutic effect of antibiotic (tobramycin) treatment combined with the infusion of the highly specific thrombin inhibitor rec. hirudin. Although administration of 2 mg/kg tobramycin alone leads to a decrease of the bacterial burden, DIC could not be prevented. Infusion of rec. hirudin (0.25 mg/kg x h) for 4 h (start of treatment 1 h post infection), in addition to a bolus administration of tobramycin, led to an amelioration of DIC parameters as fibrinogen, thrombin-antithrombin complex (TAT) and platelets. Serum transaminase levels (GOT, GPT) as a marker of MOF were significantly improved by rec. hirudin, the T50 value increased from 17 h in the tobramycin group to 42 h in the tobramycin + rec. hirudin giuup, muilality rates were 90% or 60%, respectively. Combination of heparin (10011/kg x h) and tobramycin was not effective on survival.

MR imaging of intracranial tuberculosis: Emphasis on development of lesions and therapeutic effect

1993 ◽  
Vol 29 (6) ◽  
pp. 1121
Author(s):  
Kook Sang Han ◽  
Chang Hyo Sol ◽  
Young Joon Lee ◽  
Chang Ho Choi ◽  
Sang Ook Kim ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Therapeutic Effect

Percutaneous Ethanol Ablation of Hepatic and Renal Cyst: Therapeutic Effect and Follow-Up Study

1994 ◽  
Vol 30 (2) ◽  
pp. 253 ◽  
Author(s):  
Seog Hee Park ◽  
Kyung Sub Shinn ◽  
Ki Tae Kim ◽  
Seong Tae Hahn ◽  
Choon Yul Kim ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Renal Cyst ◽  
Ethanol Ablation ◽  
Follow Up Study
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