scholarly journals A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis

2016 ◽  
Vol 36 (4) ◽  
pp. 1178-1186 ◽  
Author(s):  
Mauro Cervigni ◽  
Monica Sommariva ◽  
Raffaele Tenaglia ◽  
Daniele Porru ◽  
Edoardo Ostardo ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Dimethyl Sulfoxide ◽  
Interstitial Cystitis ◽  
Multicenter Study ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Efficacy And Safety ◽  
Open Label ◽  
Bladder Pain

scholarly journals Erratum: Chondroitin Sulfate and Hyaluronic Acid Perfusion for Interstitial Cystitis/Bladder Pain Syndrome: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 39 (5) ◽  
pp. 419
Author(s):  
Xiang Xiao ◽  
Huan Deng ◽  
Mumba Mulutula Chilufya ◽  
Yizhen Lv ◽  
Yan Zhao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Interstitial Cystitis ◽  
Meta Analysis ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Symptom Index ◽  
Bladder Pain ◽  
Acid Perfusion

Paper link corrected: https://bonoi.org/index.php/si/article/view/636 It has been brought to authors attention that there is a missing part in “Materials and Methods” of the Systematic Review article by Xiao et al., entitled “Chondroitin Sulfate and Hyaluronic Acid Perfusion for Interstitial Cystitis/Bladder Pain Syndrome: A Systematic Review and Meta-Analysis” in the Volume 39, No. 4 of Science Insights (pp.363-373). The missing part of the “Materials and Methods” is as below: Population: Patients with IC/BPS.Intervention: All patients underwent intravesical HA and/or CS treatment regimen.Comparison: Improvement in symptoms pre-treatment and post-treatment or other treatment regimen.Outcome: The primary outcome was the change in visual analogue scale (VAS) for pain symptom from baseline to the follow-up period; secondary outcomes were the changes in total scores of the O’Leary-Sant Interstitial Cystitis Symptom Index (ICSI) and Problem Index (ICPI), storage symptoms including frequency and urgency, and bladder capacity.

scholarly journals Chondroitin Sulfate and Hyaluronic Acid Perfusion for Interstitial Cystitis/Bladder Pain Syndrome: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 39 (4) ◽  
pp. 361-373
Author(s):  
Xiang Xiao ◽  
Huan Deng ◽  
Mumba Mulutula Chilufya ◽  
Yizhen Lv ◽  
Yan Zhao ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Interstitial Cystitis ◽  
Meta Analysis ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Cochrane Library ◽  
Bladder Pain ◽  
Effect Model ◽  
Significant Difference

Currently, no suitable delivery methods are available for the drugs to interstitial cystitis/ bladder pain syndrome (IC/BPS). Herein we systematically evaluated the therapeutic effects of intravesical infusion of hyaluronic acid (HA) and chondroitin sulfate (CS) in patients with IC/BPS. This study includes randomized controlled trials (RCT) and self-controlled studies of IC/BPS patients treated with HA, CS, or both. English databases like PubMed, Cochrane Library, Embase, and Medline were searched until up to January 31, 2021. Information was extracted based on the inclusion and exclusion criteria, and then meta-analysis was performed. Sixteen studies including 491 patients were included and analyzed. The responsive rate of treatment was 91.24%. In 3 RCTs, the analogue scale (VAS) for pain on fix-effect model was [mean difference, MD -0.57 (95%CI, -1.55, -0.41)]. A significant improvement on random-effect model was [MD -2.78 (95%CI, -3.48, -2.07)] in 13 self-controlled studies. Outcomes on O’Leary-Sant Interstitial Cystitis Symptom Index, Problem Index, frequency, urgency, and bladder capacity were also significantly improved. Subgroup analysis showed significant difference between HA, CS, and the combination, and the perfusion of HA was more effective (Z = 29.97, P < 0.01). Also, different follow-up times after last treatment showed significant difference (Z = 7.69, P < 0.01). It can be beneficial for IC/BPS patients who have not responded to conventional treatments.

Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis

2011 ◽  
Vol 23 (9) ◽  
pp. 1193-1199 ◽  
Author(s):  
Daniele Porru ◽  
Fabio Leva ◽  
Alberto Parmigiani ◽  
Davide Barletta ◽  
Dimitrios Choussos ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Interstitial Cystitis ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Bladder Pain

scholarly journals Hyaluronic acid degrading enzyme: TMEM2 increase in patients with interstitial cystitis and bladder pain syndrome

2020 ◽  
Vol 19 ◽  
pp. e493-e494
Author(s):  
H. Yamamoto ◽  
T. Yoneyama ◽  
I. Hamano ◽  
Y. Tobisawa ◽  
A. Imai ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Interstitial Cystitis ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Bladder Pain ◽  
Degrading Enzyme
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