Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis

2013 ◽  
Vol 34 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Woong-Jin Bae ◽  
U-Syn Ha ◽  
Seol Kim ◽  
Su-Jin Kim ◽  
Sung-Hoo Hong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrochloric Acid ◽  
Rat Model ◽  
The Novel ◽  
Herbal Formulation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Investigation of anti-inflammatory effects of oxygen nanobubbles in a rat hydrochloric acid lung injury model

Nanomedicine ◽  
2020 ◽  
Vol 15 (27) ◽  
pp. 2647-2654
Author(s):  
Keisuke Yoshida ◽  
Yukihiro Ikegami ◽  
Shinju Obara ◽  
Keiko Sato ◽  
Masahiro Murakawa
Keyword(s):  
Acute Lung Injury ◽  
Mean Arterial Pressure ◽  
Hydrochloric Acid ◽  
Lung Injury ◽  
Arterial Pressure ◽  
Rat Model ◽  
Injury Model ◽  
Lung Injury Model ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Aim: To investigate the anti-inflammatory effect of oxygen nanobubbles (ONBs) in an acute lung injury rat model. Materials & methods: In a rat hydrochloric acid lung injury model, ONB fluid was administered intravenously in the ONB group (n = 6) and normal saline was administered in the control group (n = 6). 4 h later, arterial partial pressure of oxygen (PaO2), mean arterial pressure and plasma inflammatory cytokines were measured. Results: There were no significant differences in the PaO2, mean arterial pressure or TNF-α and IL-6 levels between the two groups. Conclusions: No anti-inflammatory effect could be confirmed at the present ONB dose in the rat model of acute lung injury.

W1706 Anti-Inflammatory Effect of Vagus Nerve Stimulation in a Rat Model of Colitis

2009 ◽  
Vol 136 (5) ◽  
pp. A-721
Author(s):  
Julien Meregnani ◽  
Clarençon Didier ◽  
Chloé A. Picq ◽  
Valérie Sinniger ◽  
Bruno L. Bonaz
Keyword(s):  
Vagus Nerve ◽  
Rat Model ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals The Anti-Inflammatory Effect of Pistacia Lentiscus in a Rat Model of Colitis

2020 ◽  
Vol Volume 13 ◽  
pp. 369-376
Author(s):  
Maryam Ostovan ◽  
Seyyed Mohammad Bagher Fazljou ◽  
Hajar Khazraei ◽  
Mostafa Araj Khodaei ◽  
Mohammadli Torbati
Keyword(s):  
Rat Model ◽  
Pistacia Lentiscus ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals In Vivo Imaging of Leukocyte Recruitment to the Atheroprone Femoral Artery Reveals Anti-Inflammatory Effects of Rosuvastatin

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Mizuko Osaka ◽  
Sumihiko Hagita ◽  
Masayuki Yoshida
Keyword(s):  
Oxidative Stress ◽  
Femoral Artery ◽  
Leukocyte Adhesion ◽  
Underlying Mechanism ◽  
Leukocyte Recruitment ◽  
Hmg Coa Reductase Inhibitor ◽  
Anti Inflammatory ◽  
Coa Reductase ◽  
Inflammatory Effect

Objective. To monitor the anti-inflammatory effect of rosuvastatin in leukocyte endothelial interactions in the atheroprone femoral artery in vivo.Methods and Results. Male Apolipoprotein E null mice (ApoE−/− mice, 6 weeks old) were fed a high-fat diet (20% fat, 1.25% cholesterol) with or without the HMG CoA reductase inhibitor rosuvastatin (10 mg/kg/day) for 6 weeks. Significant leukocyte adhesion was observed in the femoral artery of ApoE−/− mice, but not of wild type mice, in the absence of rosuvastatin. Interestingly, no obvious plaque formation was observed in the artery at this time point. The number of adherent leukocytes was dramatically diminished in ApoE−/− mice treated with rosuvastatin. DHE-associated oxidative stress and the expression of gp91-phox, a component of NADPH oxidase, were induced in ApoE−/− mice and were abolished by rosuvastatin treatment.Conclusion. Our data documented leukocyte recruitment prior to lipid accumulation and subsequent inhibition by rosuvastatin. The underlying mechanism seemed to involve oxidative stress and an anti-inflammatory effect on the endothelium of atheroprone vessels.

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