Re: Kanai A, et al. mechanisms of action of botulinum neurotoxins, β3-adrenergic receptor agonists, and PDE5 inhibitors in modulating detrusor function in overactive bladders: ICI-RS 2011. Neurourol urodyn 2012;31:300-308

2012 ◽  
Vol 31 (5) ◽  
pp. 707-707
Author(s):  
Masayuki Takeda
Keyword(s):  
Adrenergic Receptor ◽  
Mechanisms Of Action ◽  
Pde5 Inhibitors ◽  
Receptor Agonists ◽  
Botulinum Neurotoxins ◽  
Detrusor Function

620 β-Adrenergic receptor agonists- and cAMP-mediated suppression of the proliferation of microglial cells in culture

1997 ◽  
Vol 28 ◽  
pp. S89
Author(s):  
Masahiro Sakanaka ◽  
Hiroko Fujita ◽  
Junya Tanaka ◽  
Seiji Matsuda ◽  
Nobuji Maeda
Keyword(s):  
Adrenergic Receptor ◽  
Microglial Cells ◽  
Receptor Agonists ◽  
Cells In Culture

Guanabenz and Clonidine, α2-Adrenergic Receptor Agonists, Inhibit Choroidal Neovascularization

2021 ◽  
Vol 18 ◽  
Author(s):  
Miruto Tanaka ◽  
Yuki Inoue ◽  
Takahiko Imai ◽  
Norifumi Tanida ◽  
Koichi Takahashi ◽  
...  
Keyword(s):  
Choroidal Neovascularization ◽  
Adrenergic Receptor ◽  
Intraperitoneal Administration ◽  
Age Related Macular Degeneration ◽  
High Dose ◽  
Adrenergic Agonists ◽  
Continuous Administration ◽  
Cell Growth And Migration ◽  
Receptor Agonists ◽  
Age Related

Background: Neovascular age-related macular degeneration (AMD) with choroidal neovascularization (CNV) is a leading cause of blindness in elderly people. Anti-vascular endothelial growth factor (anti-VEGF)-drugs are used to treat AMD patients; however, some patients are resistant to these therapies. Objective: The purpose of this study was to investigate the anti-angiogenic effects of α2-adrenergic agonists, including guanabenz and clonidine. Methods: We evaluated the anti-angiogenic effects of α2-adrenergic agonists in human retinal microvascular endothelial cells (HRMECs). A proliferation assay was conducted, and the migration ratio was evaluated. In a laser-induced CNV model, guanabenz and clonidine were delivered via intraperitoneal injection or implantation of an osmotic pump device. Fourteen days following CNV induction, CNV lesion size and fundus fluorescein angiography (FFA) were evaluated. Results: Guanabenz and clonidine inhibited VEGF-induced retinal endothelial cell growth and migration. In the CNV model mice, CNV lesion sizes were reduced by intraperitoneal administration of guanabenz or clonidine. Data, including body weight, systolic blood pressure, and heart rate showed that guanabenz (0.5 and 2.0 mg/kg/day) had little effect on these parameters; conversely, a high dose of clonidine (1.0 mg/kg/day) did affect these parameters. Additionally, clonidine did not affect CNV size, but continuous administration of guanabenz attenuated both CNV size and leakage from neovessels. Conclusion: Our study suggests a key role for α2-adrenergic receptors during CNV formation. Therefore, we suggest that α2-adrenergic receptor agonists may represent novel therapeutic drugs for patients with neovascular AMD.

Proglucagon-Derived Peptides: Mechanisms of Action and Therapeutic Potential

Physiology ◽  
2005 ◽  
Vol 20 (5) ◽  
pp. 357-365 ◽  
Author(s):  
Elaine M Sinclair ◽  
Daniel J. Drucker
Keyword(s):  
Type 2 Diabetes ◽  
Human Disease ◽  
Clinical Relevance ◽  
Therapeutic Potential ◽  
Mechanisms Of Action ◽  
Receptor Antagonists ◽  
Glucagon Receptor ◽  
Receptor Agonists ◽  
Glucagon Like Peptide

Glucagon is used for the treatment of hypoglycemia, and glucagon receptor antagonists are under development for the treatment of type 2 diabetes. Moreover, glucagon-like peptide (GLP)-1 and GLP-2 receptor agonists appear to be promising therapies for the treatment of type 2 diabetes and intestinal disorders, respectively. This review discusses the physiological, pharmacological, and therapeutic actions of the proglucagon-derived peptides, with an emphasis on clinical relevance of the peptides for the treatment of human disease.

3-pyridylethanolamines: Potent and selective human β3 adrenergic receptor agonists

1998 ◽  
Vol 8 (21) ◽  
pp. 3087-3092 ◽  
Author(s):  
Elizabeth M. Naylor ◽  
Vincent J. Colandrea ◽  
Mari R. Candelore ◽  
Margaret A. Cascieri ◽  
Lawrence F. Colwell ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonists

scholarly journals Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Maki Kotaka ◽  
Taro Toyoda ◽  
Katsutaro Yasuda ◽  
Yuko Kitano ◽  
Chihiro Okada ◽  
...  
Keyword(s):  
Stem Cell ◽  
Adrenergic Receptor ◽  
Pluripotent Stem Cell ◽  
Receptor Agonists
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