Bone marrow mesenchymal stromal cell therapy for external urethral sphincter restoration in a rat model of stress urinary incontinence

2010 ◽  
Vol 30 (3) ◽  
pp. 447-455 ◽  
Author(s):  
Jacques Corcos ◽  
Oleg Loutochin ◽  
Lysanne Campeau ◽  
Nicoletta Eliopoulos ◽  
Manaf Bouchentouf ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Cell Therapy ◽  
Rat Model ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Urethral Sphincter ◽  
External Urethral Sphincter

Effects of Allogeneic Bone Marrow Derived Mesenchymal Stromal Cell Therapy on Voiding Function in a Rat Model of Parkinson Disease

2014 ◽  
Vol 191 (3) ◽  
pp. 850-859 ◽  
Author(s):  
Lysanne Campeau ◽  
Roberto Soler ◽  
Sivanandane Sittadjody ◽  
Rajesh Pareta ◽  
Masanori Nomiya ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Therapy ◽  
Parkinson Disease ◽  
Rat Model ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone ◽  
Voiding Function

Bone marrow–derived mesenchymal stromal cell therapy in a rat model of cavernous nerve injury: Preclinical study for approval

Cytotherapy ◽  
2016 ◽  
Vol 18 (7) ◽  
pp. 870-880 ◽  
Author(s):  
Dalsan You ◽  
Myoung Jin Jang ◽  
Bo Hyun Kim ◽  
Ki Ryung Choi ◽  
Chunwoo Lee ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Therapy ◽  
Nerve Injury ◽  
Rat Model ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Preclinical Study ◽  
Cavernous Nerve ◽  
Cavernous Nerve Injury

scholarly journals Electrical stimulation of the pudendal nerve promotes neuroregeneration and functional recovery from stress urinary incontinence in a rat model

2018 ◽  
Vol 315 (6) ◽  
pp. F1555-F1564 ◽  
Author(s):  
Hai-Hong Jiang ◽  
Qi-Xiang Song ◽  
Bradley C. Gill ◽  
Brian M. Balog ◽  
Raul Juarez ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Electrical Stimulation ◽  
Stress Urinary Incontinence ◽  
Rat Model ◽  
Pudendal Nerve ◽  
External Urethral Sphincter ◽  
Sham Stimulation ◽  
Point Pressure ◽  
Separate Cohort ◽  
Stimulation Of

The pudendal nerve can be injured during vaginal delivery of children, and slowed pudendal nerve regeneration has been correlated with development of stress urinary incontinence (SUI). Simultaneous injury to the pudendal nerve and its target muscle, the external urethral sphincter (EUS), during delivery likely leads to slowed neuroregeneration. The goal of this study was to determine if repeat electrical stimulation of the pudendal nerve improves SUI recovery and promotes neuroregeneration in a dual muscle and nerve injury rat model of SUI. Rats received electrical stimulation or sham stimulation of the pudendal nerve twice weekly for up to 2 wk after injury. A separate cohort of rats received sham injury and sham stimulation. Expression of brain-derived neurotrophic factor (BDNF) and βII-tubulin expression in Onuf’s nucleus were measured 2, 7, and 14 days after injury. Urodynamics, leak point pressure (LPP), and EUS electromyography (EMG) were recorded 14 days after injury. Electrical stimulation significantly increased expression of BDNF at all time points and βII-tubulin 1 and 2 wk after injury. Two weeks after injury, LPP and EUS EMG during voiding and LPP testing were significantly decreased compared with sham-injured animals. Electrical stimulation significantly increased EUS activity during voiding, although LPP did not fully recover. Repeat pudendal nerve stimulation promotes neuromuscular continence mechanism recovery possibly via a neuroregenerative response through BDNF upregulation in the pudendal motoneurons in this model of SUI. Electrical stimulation of the pudendal nerve may therefore improve recovery after childbirth and ameliorate symptoms of SUI by promoting neuroregeneration after injury.

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