Bladder volume sensitivity of isovolumetric intravesical pressure

2006 ◽  
Vol 25 (7) ◽  
pp. 744-751 ◽  
Author(s):  
R. van Mastrigt ◽  
J.W.N.C. Huang Foen Chung
Keyword(s):  
Bladder Volume ◽  
Intravesical Pressure ◽  
Volume Sensitivity

scholarly journals Detrusor expulsive strength is preserved, but responsiveness to bladder filling and urinary sensitivity is diminished in the aging mouse

2012 ◽  
Vol 302 (5) ◽  
pp. R577-R586 ◽  
Author(s):  
Phillip P. Smith ◽  
Anthony DeAngelis ◽  
George A. Kuchel
Keyword(s):  
Wall Stress ◽  
Bladder Volume ◽  
Bladder Function ◽  
Bladder Pressure ◽  
Volume Data ◽  
Detrusor Contraction ◽  
Bladder Filling ◽  
Volume Sensitivity ◽  
Old Mice

The prevalence of urinary symptoms increases with age and is a significant source of distress, morbidity, and expense in the elderly. Recent evidence suggests that symptoms in the aged may result from sensory dysfunction, rather than abnormalities of detrusor performance. Therefore, we employed a pressure/flow multichannel urethane-anesthetized mouse cystometry model to test the hypothesis that in vivo detrusor performance does not degrade with aging. Secondarily, we sought to evaluate sensory responsiveness to volume using pressure-volume data generated during bladder filling. Cystometric data from 2-, 12-, 22-, and 26-mo-old female C57BL6 mice were compared. All 2- and 12-mo-old mice, 66% of 22-mo-old mice, and 50% of 26-mo-old mice responded to continuous bladder filling with periodic reflex voiding. Abdominal wall contraction with voiding had a minimal contribution to expulsive pressure, whereas compliance pressure was a significant contributor. Maximum bladder pressure, estimated detrusor pressure, detrusor impulse (pressure-time integral), as well as indices of detrusor power and work, did not decrease with aging. Bladder precontraction pressures decreased, compliance increased, and nonvoiding contraction counts did not change with increasing age. Intervoid intervals, per-void volumes, and voiding flow rates increased with age. Calculations approximating wall stress during filling suggested loss of bladder volume sensitivity with increasing age. We conclude that aging is associated with an impaired ability to respond to the challenge of continuous bladder filling with cyclic voiding, yet among responsive animals, voiding detrusor contraction strength does not degrade with aging in this murine model. Furthermore, indirect measures suggest that bladder volume sensitivity is diminished. Thus, changes in homeostatic reserve and peripheral and/or central sensory mechanisms may be important contributors to aging-associated changes in bladder function.

Impact of Bladder Wall Thickness on the Outcomes of Antimuscarinic Treatment in Women with Overactive Bladder

2021 ◽  
pp. 1-7
Author(s):  
Sherif Salah Azab ◽  
Omar El Sayed ◽  
Mona El Kafoury
Keyword(s):  
Overactive Bladder ◽  
Wall Thickness ◽  
Bladder Wall ◽  
Bladder Volume ◽  
Transabdominal Ultrasound ◽  
Intravesical Pressure ◽  
Oral Tablet ◽  
Bladder Wall Thickness ◽  
Group 2 ◽  
Group 1

<b><i>Aim:</i></b> This study aimed to evaluate the effect of bladder wall thickness (BWT) (using transabdominal ultrasound) on the outcomes of antimuscarinic treatment in women with overactive bladder. <b><i>Methods:</i></b> A total of 102 female patients with symptoms of OAB were recruited. All patients completed the Overactive Bladder version 8 (OAB-V8) (Arabic validation) and the International Consultation of Incontinence Questionnaire (ICIQ-SF). Patients completed the urodynamic study (UDS) including uroflowmetry and PVR and measures of BWT by transabdominal ultrasound. The patients were classified into 2 major groups: G1 (patients with BWT &#x3c;5 mm) and G2 (patients with BWT ≥5 mm). The patients were re-evaluated after 3-month medication with solifenacin 10-mg oral tablet. <b><i>Results:</i></b> At baseline, the results of OAB-V8 and ICIQ-SF were significantly higher in G2 than G1 (<i>p</i> &#x3c; 0.001). Regarding UDS, volume at 1st desire to void, volume at strong desire to void, and MBC were significantly higher in group 1 compared to group 2 (<i>p</i> = 0.001). Intravesical pressure at strong desire and patients’ number of DO were significantly increased in G2 (<i>p</i> &#x3c; 0.05 and <i>p</i> = 0.001, respectively). After treatment, there was an improvement in both groups regarding OAB-V8, ICIQ-SF, bladder volume at 1st desire to void, bladder volume at strong desire to void, bladder volume at DO, MBC, intravesical pressure at strong desire, and the patients’ number with DO (decreased), and these improvements were statistically significant in group 1 compared to group 2 (<i>p</i> &#x3c; 0.05). <b><i>Conclusion:</i></b> BWT showed a significant association with both OAB symptom scores and UDS parameters. The decrease in BWT is associated with a significantly higher response to solifenacin therapy regarding the UDS results.

scholarly journals Soft sensors for a sensing-actuation system with high bladder voiding efficiency

2020 ◽  
Vol 6 (18) ◽  
pp. eaba0412 ◽  
Author(s):  
F. Arab Hassani ◽  
H. Jin ◽  
T. Yokota ◽  
T. Someya ◽  
N. V. Thakor
Keyword(s):  
High Performance ◽  
Capacitive Sensor ◽  
Bladder Volume ◽  
Soft Sensors ◽  
Volume Changes ◽  
Actuation System ◽  
Volume Sensitivity ◽  
Bladder Management ◽  
Weak Muscle ◽  
Actuation Systems

Sensing-actuation systems can assist a bladder with lost sensation and weak muscle control. Here, we advance the relevant technology by integrating a soft and thin capacitive sensor with a shape memory alloy–based actuator to achieve a high-performance closed-loop configuration. In our design, sensors capable of continuous bladder volume detection and actuators with strong emptying force have been used. This integration has previously hindered performance due to large bladder volume changes. Our solution integrates sensing-actuation elements that are bladder compatible but do not interfere with one another, achieving real-time bladder management. The system attains a highly desirable voiding target of 71 to 100% of a rat’s bladder with a volume sensitivity of 0.7 μF/liter. Our system represents an efficient voiding solution that avoids overfilling and represents a technological solution to bladder impairment treatment, serving as a model for similar soft sensor-actuator integration with other organs.

scholarly journals BladderScan Feedback Method in Predicting Bladder Filling for Prostate Radiotherapy: A Prospective Study

2021 ◽  
Vol 20 ◽  
pp. 153303382199527
Author(s):  
Deng-Yu Kuo ◽  
Chen-Yang Hsu ◽  
Wei-Chun Wang ◽  
Hsiu-Hsi Chen ◽  
Pei-Wei Shueng
Keyword(s):  
Prostate Cancer ◽  
Failure Rate ◽  
Conventional Method ◽  
Bladder Volume ◽  
Relative Reduction ◽  
Radiation Cystitis ◽  
Prostate Radiotherapy ◽  
Bladder Filling ◽  
Feedback Method ◽  
A Prospective Study

Purpose: Approximately 5%–10% of men who receive prostate cancer radiotherapy will suffer from radiation cystitis. Bladder filling before the administration of radiotherapy results in lower radiation exposure to the bladder. BladderScan, an ultrasound-based bladder volume scanner, has the potential to evaluate bladder volume during radiotherapy; thus, a prospective pilot study was initiated. Methods: Eleven men receiving tomotherapy for localized prostate cancer were enrolled. The validity of BladderScan was evaluated by comparing the measurements from BladderScan with the calculated volume from megavoltage computed tomography (MVCT). With a crossover design to compare different methods in bladder filling, the radiotherapy was divided into 2 sequences. Conventional method: the patient was asked to drink water after voiding urine. The amount of water and the duration of waiting were the same as in the setting of the simulation. BladderScan feedback method: the bladder filling procedure depended on the BladderScan measurements. Results: There were 314 sets of data from 11 patients. The correlation coefficient between VBS and VCT was 0.87, where VBS is the mean volume of 3 measurements by BladderScan and VCT is the bladder volume derived from MVCT. The BladderScan feedback method resulted in a significant larger bladder volume than the conventional method, with a mean difference of 36.9 mL. When the failure was defined as VCT <80% of planned volume, the BladderScan feedback method brought about a relative reduction in the failure rate with an odds ratio of 0.44 and an absolute reduction of 9.1%. Conclusion: The accuracy of BladderScan was validated by MVCT in our study. The BladderScan feedback method can help patients fill the bladder adequately, with a larger bladder volume and a lower failure rate.

Non-Invasive Measurement of Intravesical Pressure

1987 ◽  
Vol 138 (1) ◽  
pp. 231-231
Author(s):  
K.K. Sethia ◽  
J.C. Smith
Keyword(s):  
Intravesical Pressure ◽  
Non Invasive ◽  
Invasive Measurement
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