Effect of Doxazosin on rat urinary bladder function after partial outlet obstruction

2002 ◽  
Vol 21 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Anurag K. Das ◽  
Robert E. Leggett ◽  
Catherine Whitbeck ◽  
George Eagen ◽  
Robert M. Levin
Keyword(s):  
Urinary Bladder ◽  
Outlet Obstruction ◽  
Bladder Function ◽  
Rat Urinary Bladder

scholarly journals A possible role of the cholinergic and purinergic receptor interaction in the regulation of the rat urinary bladder function

2012 ◽  
Vol 32 (6) ◽  
pp. 421-431 ◽  
Author(s):  
Ágnes Jenes ◽  
Ferenc Ruzsnavszky ◽  
Andrea Telek ◽  
Gyula P. Szigeti ◽  
László Csernoch
Keyword(s):  
Urinary Bladder ◽  
Purinergic Receptor ◽  
Bladder Function ◽  
Receptor Interaction ◽  
Rat Urinary Bladder

scholarly journals Role of p75NTR in female rat urinary bladder with cyclophosphamide-induced cystitis

2008 ◽  
Vol 295 (6) ◽  
pp. F1778-F1789 ◽  
Author(s):  
Mary Beth Klinger ◽  
Margaret A. Vizzard
Keyword(s):  
Urinary Bladder ◽  
Intravesical Instillation ◽  
Bladder Function ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Female Rat ◽  
Rat Urinary Bladder ◽  
Micturition Reflex ◽  
Reflex Pathways

Previous studies demonstrated changes in urinary bladder neurotrophin content and upregulation of neurotrophin receptors, TrkA and the p75 neurotrophin receptor (p75NTR), in micturition reflex pathways after cyclophosphamide (CYP)-induced cystitis. p75NTR can bind nerve growth factor (NGF) and modulate NGF-TrkA binding and signaling. We examined p75NTR expression and the role of p75NTR in the micturition reflex in control and CYP-treated rats. p75NTR Immunoreactivity was present throughout the urinary bladder. CYP-induced cystitis (4 h, 48 h, chronic) increased ( P ≤ 0.05) p75NTR expression in whole urinary bladder as shown by Western blotting. The role of p75NTR in bladder function in control and CYP-treated rats was determined using conscious cystometry and immunoneutralization or PD90780, a compound known to specifically block NGF binding to p75NTR. An anti-p75NTR monoclonal antibody or PD90780 was infused intravesically and cystometric parameters were evaluated. Both methods of p75NTR blockade significantly ( P ≤ 0.05) decreased the intercontraction interval and void volume in control and CYP-treated rats. Intravesical infusion of PD90780 also significantly ( P ≤ 0.001) increased intravesical pressure and increased the number of nonvoiding contractions during the filling phase. Control intravesical infusions of isotype-matched IgG and vehicle were without effect. Intravesical instillation of PD90780 significantly ( P ≤ 0.01) reduced the volume threshold to elicit a micturition contraction in control rats (no inflammation) and CYP-treated in a closed urinary bladder system. These studies demonstrate 1) ubiquitous p75NTR expression in urinary bladder and increased expression with CYP-induced cystitis and 2) p75NTR blockade at the level of the urinary bladder produces bladder hyperreflexia in control and CYP-treated rats. The overall activity of the urinary bladder reflects the balance of NGF-p75NTR and NGF-TrkA signaling.

scholarly journals Review of Animal Models to Study Urinary Bladder Function

Biology ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1316
Author(s):  
Jing-Dung Shen ◽  
Szu-Ju Chen ◽  
Huey-Yi Chen ◽  
Kun-Yuan Chiu ◽  
Yung-Hsiang Chen ◽  
...  
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Urinary Bladder ◽  
Outlet Obstruction ◽  
Bladder Function ◽  
Laboratory Facility ◽  
Point Pressure ◽  
Bladder Disorders ◽  
Multiple Symptoms ◽  
Mini Pigs

The urinary bladder (UB) serves as a storage and elimination organ for urine. UB dysfunction can cause multiple symptoms of failure to store urine or empty the bladder, e.g., incontinence, frequent urination, and urinary retention. Treatment of these symptoms requires knowledge on bladder function, which involves physiology, pathology, and even psychology. There is no ideal animal model for the study of UB function to understand and treat associated disorders, as the complexity in humans differs from that of other species. However, several animal models are available to study a variety of other bladder disorders. Such models include animals from rodents to nonhuman primates, such as mice, rats, rabbits, felines, canines, pigs, and mini pigs. For incontinence, vaginal distention might mimic birth trauma and can be measured based on leak point pressure. Using peripheral and central models, inflammation, bladder outlet obstruction, and genetic models facilitated the study of overactive bladder. However, the larger the animal model, the more difficult the study is, due to the associated animal ethics issues, laboratory facility, and budget. This review aims at facilitating adapted animal models to study bladder function according to facility, priority, and disease.

FUNCTION OF M3 MUSCARINIC RECEPTORS IN THE RAT URINARY BLADDER FOLLOWING PARTIAL OUTLET OBSTRUCTION

1999 ◽  
pp. 1644-1650 ◽  
Author(s):  
VLADIMIR P. KRICHEVSKY ◽  
MURALI K. PAGALA ◽  
IGOR VAYDOVSKY ◽  
VIJAYSINGH DAMER ◽  
GILBERT J. WISE
Keyword(s):  
Urinary Bladder ◽  
Muscarinic Receptors ◽  
Outlet Obstruction ◽  
Rat Urinary Bladder
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