scholarly journals Lung volume recruitment improves volitional airway clearance in amyotrophic lateral sclerosis

2021 ◽  
Author(s):  
Stuart Cleary ◽  
John E. Misiaszek ◽  
Sonya Wheeler ◽  
Sanjay Kalra ◽  
Shelagh K. Genuis ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Lung Volume ◽  
Airway Clearance ◽  
Lung Volume Recruitment ◽  
Lateral Sclerosis

scholarly journals Lung Insufflation Capacity with a New Device in Amyotrophic Lateral Sclerosis: Measurement of the Lung Volume Recruitment in Respiratory Therapy

2020 ◽  
Vol 5 (0) ◽  
pp. n/a
Author(s):  
Keisuke Yorimoto ◽  
Yosuke Ariake ◽  
Takako Saotome ◽  
Madoka Mori-Yoshimura ◽  
Tadashi Tsukamoto ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Lung Volume ◽  
Respiratory Therapy ◽  
New Device ◽  
Lung Volume Recruitment ◽  
Lateral Sclerosis

Feasibility of Lung Volume Recruitment in Early Neuromuscular Weakness: A Comparison Between Amyotrophic Lateral Sclerosis, Myotonic Dystrophy, and Postpolio Syndrome

PM&R ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 677-684 ◽  
Author(s):  
Marta Kaminska ◽  
Franceen Browman ◽  
Daria A. Trojan ◽  
Angela Genge ◽  
Andrea Benedetti ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Myotonic Dystrophy ◽  
Lung Volume ◽  
Postpolio Syndrome ◽  
Lung Volume Recruitment ◽  
Lateral Sclerosis

scholarly journals Current issues in the respiratory care of patients with amyotrophic lateral sclerosis

2015 ◽  
Vol 73 (10) ◽  
pp. 873-876 ◽  
Author(s):  
Marco Orsini ◽  
Agnaldo José Lopes ◽  
Sara Lucia Silveira de Menezes ◽  
Acary Bulle Oliveira ◽  
Marcos Raimundo Gomes de Freitas ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Vital Capacity ◽  
Peak Flow ◽  
Respiratory Care ◽  
Airway Clearance ◽  
Care Approach ◽  
Pulmonary Volumes ◽  
Lateral Sclerosis ◽  
Sniff Nasal Inspiratory Pressure

Amyotrophic lateral sclerosis is a progressive neuromuscular disease, resulting in respiratory muscle weakness, reduced pulmonary volumes, ineffective cough, secretion retention, and respiratory failure. Measures as vital capacity, maximal inspiratory and expiratory pressures, sniff nasal inspiratory pressure, cough peak flow and pulse oximetry are recommended to monitor the respiratory function. The patients should be followed up by a multidisciplinary team, focused in improving the quality of life and deal with the respiratory symptoms. The respiratory care approach includes airway clearance techniques, mechanically assisted cough and noninvasive mechanical ventilation. Vaccination and respiratory pharmacological support are also recommended. To date, there is no enough evidence supporting the inspiratory muscle training and diaphragmatic pacing.

An Overview of Respiratory Treatments for Individuals With Amyotrophic Lateral Sclerosis 1

2013 ◽  
Vol 22 (1) ◽  
pp. 17-25
Author(s):  
Stuart Cleary ◽  
Janice Richman-Eisenstat
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Respiratory Failure ◽  
Life Expectancy ◽  
High Likelihood ◽  
Limited Life Expectancy ◽  
Breathing Difficulty ◽  
Airway Clearance ◽  
Limited Life ◽  
Lateral Sclerosis

Given the limited life expectancy of individuals diagnosed with amyotrophic lateral sclerosis (ALS) and the high likelihood that patients will suffer from a breathing difficulty and an encumbered airway, promoting the highest level in the ability to maintain an open and clear airway is of the utmost importance to patients and their families. In this article, authors describe the basic mechanisms of neuromuscular-induced respiratory failure and explain the underlying physiological rationale for four commonly used respiratory treatments in cases of advanced ALS. The article also includes research on the use of manual breath stacking to improve coughing and airway clearance while swallowing.

Automated Acoustic Analysis of Oral Diadochokinesis to Assess Bulbar Motor Involvement in Amyotrophic Lateral Sclerosis

2020 ◽  
Vol 63 (1) ◽  
pp. 59-73 ◽  
Author(s):  
Panying Rong
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Acoustic Analysis ◽  
Speaking Rate ◽  
Disease Stage ◽  
Healthy Controls ◽  
Tongue Movement ◽  
Major Barrier ◽  
Syllable Repetition ◽  
Oral Diadochokinesis ◽  
Lateral Sclerosis

Purpose The purpose of this article was to validate a novel acoustic analysis of oral diadochokinesis (DDK) in assessing bulbar motor involvement in amyotrophic lateral sclerosis (ALS). Method An automated acoustic DDK analysis was developed, which filtered out the voice features and extracted the envelope of the acoustic waveform reflecting the temporal pattern of syllable repetitions during an oral DDK task (i.e., repetitions of /tɑ/ at the maximum rate on 1 breath). Cycle-to-cycle temporal variability (cTV) of envelope fluctuations and syllable repetition rate (sylRate) were derived from the envelope and validated against 2 kinematic measures, which are tongue movement jitter (movJitter) and alternating tongue movement rate (AMR) during the DDK task, in 16 individuals with bulbar ALS and 18 healthy controls. After the validation, cTV, sylRate, movJitter, and AMR, along with an established clinical speech measure, that is, speaking rate (SR), were compared in their ability to (a) differentiate individuals with ALS from healthy controls and (b) detect early-stage bulbar declines in ALS. Results cTV and sylRate were significantly correlated with movJitter and AMR, respectively, across individuals with ALS and healthy controls, confirming the validity of the acoustic DDK analysis in extracting the temporal DDK pattern. Among all the acoustic and kinematic DDK measures, cTV showed the highest diagnostic accuracy (i.e., 0.87) with 80% sensitivity and 94% specificity in differentiating individuals with ALS from healthy controls, which outperformed the SR measure. Moreover, cTV showed a large increase during the early disease stage, which preceded the decline of SR. Conclusions This study provided preliminary validation of a novel automated acoustic DDK analysis in extracting a useful measure, namely, cTV, for early detection of bulbar ALS. This analysis overcame a major barrier in the existing acoustic DDK analysis, which is continuous voicing between syllables that interferes with syllable structures. This approach has potential clinical applications as a novel bulbar assessment.

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