scholarly journals Obligatory role of Schwann cell‐specific erythropoietin receptors in erythropoietin‐induced functional recovery and neurogenic muscle atrophy after nerve injury

2020 ◽  
Author(s):  
M A Hassan Talukder ◽  
Jung Il Lee ◽  
John P. Hegarty ◽  
Anagha A. Gurjar ◽  
Mary O'Brien ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Nerve Injury ◽  
Muscle Atrophy ◽  
Functional Recovery

scholarly journals Role of IL-10 in Resolution of Inflammation and Functional Recovery after Peripheral Nerve Injury

2015 ◽  
Vol 35 (50) ◽  
pp. 16431-16442 ◽  
Author(s):  
B. Siqueira Mietto ◽  
A. Kroner ◽  
E. I. Girolami ◽  
E. Santos-Nogueira ◽  
J. Zhang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Resolution Of Inflammation

scholarly journals Diagnostic and Prognostic Value of Electromyographic Studies in Peripheral Nerve Injury

2017 ◽  
Vol 1 (1) ◽  
pp. 65-70
Author(s):  
P.K. Gupta ◽  
P.P. Kotwal ◽  
M. Bhatiya ◽  
R. Mittal ◽  
N.M. Shrestha
Keyword(s):  
Cohort Study ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Prognostic Value ◽  
Health Sciences ◽  
Medical Sciences ◽  
Diagnostic And Prognostic Value

Introduction Electro diagnostic studies provide the surgeons with critical information regarding the location, severity and nature of a nerve injury and also useful in predicting and assessing improvement during treatment either conservatively or surgically .Objective To evaluate the role of diagnostic and prognostic value of Electromyographic (EMG) studies in Peripheral Nerve injury.Methodology Fifty patients, having peripheral nerve injury were evaluated clinically and electro-physiologically to determine the role played by the latter in the management of such injuries. The study was prospective cohort study conducted at All India Institute of medical sciences, New Delhi.Results The most common mode of nerve injury was transection(54%) and most common nerve involved was radial (38%). The most common types of nerve injury in our study were axonotmesis (42%). Nature of injury was evaluated clinically and electrophysiologically.Consclusions Electromyographic studies in peripheral nerve injury are helpful in diagnosing nerve injury, in localizing the site of injury and in estimating the extent of injury. EMG studies cannot give correct prognostic or quantify the functional recovery, but act as a useful modality to decide for re-exploration in operated cases.Birat Journal of Health Sciences 2016 1(1): 65-70

scholarly journals Differential effects of 4‐aminopyridine on nerve injury severity‐dependent functional recovery and muscle atrophy in mice

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
M. A. Talukder ◽  
Jung Il Lee ◽  
Zara Karuman ◽  
Prem Kumar Govindappa ◽  
Mashanipalya Jagadeeshaprasad ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Muscle Atrophy ◽  
Functional Recovery ◽  
Injury Severity ◽  
Differential Effects

scholarly journals Ablation of adhesion molecule L1 in mice favours Schwann cell proliferation and functional recovery after peripheral nerve injury

Brain ◽  
2009 ◽  
Vol 132 (8) ◽  
pp. 2180-2195 ◽  
Author(s):  
Daria Guseva ◽  
Doychin N. Angelov ◽  
Andrey Irintchev ◽  
Melitta Schachner
Keyword(s):  
Cell Proliferation ◽  
Schwann Cell ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Adhesion Molecule ◽  
Functional Recovery ◽  
Peripheral Nerve Injury

scholarly journals RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation

2019 ◽  
Vol 218 (7) ◽  
pp. 2370-2387 ◽  
Author(s):  
Jorge Galino ◽  
Ilaria Cervellini ◽  
Ning Zhu ◽  
Nina Stöberl ◽  
Meike Hütte ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Nerve Injury ◽  
Nerve Repair ◽  
Small Gtpases ◽  
Membrane Dynamics ◽  
Process Formation ◽  
Ral Gtpases ◽  
Injury And Repair ◽  
Recovery Of Motor Function

RalA and RalB are small GTPases that are involved in cell migration and membrane dynamics. We used transgenic mice in which one or both GTPases were genetically ablated to investigate the role of RalGTPases in the Schwann cell (SC) response to nerve injury and repair. RalGTPases were dispensable for SC function in the naive uninjured state. Ablation of both RalA and RalB (but not individually) in SCs resulted in impaired axon remyelination and target reinnervation following nerve injury, which resulted in slowed recovery of motor function. Ral GTPases were localized to the leading lamellipodia in SCs and were required for the formation and extension of both axial and radial processes of SCs. These effects were dependent on interaction with the exocyst complex and impacted on the rate of SC migration and myelination. Our results show that RalGTPases are required for efficient nerve repair by regulating SC process formation, migration, and myelination, therefore uncovering a novel role for these GTPases.

Age-Dependent Schwann Cell Phenotype Regulation Following Peripheral Nerve Injury

2017 ◽  
Vol 22 (04) ◽  
pp. 464-471 ◽  
Author(s):  
Wayne A. Chen ◽  
T. David Luo ◽  
Jonathan C. Barnwell ◽  
Thomas L. Smith ◽  
Zhongyu Li
Keyword(s):  
Young Adult ◽  
Schwann Cell ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Adolescent And Young Adult ◽  
Post Injury ◽  
Adult Rats ◽  
Regulatory Factors

Background: Schwann cells are integral to the regenerative capacity of the peripheral nervous system, which declines after adolescence. The mechanisms underlying this decline are poorly understood. This study sought to compare the protein expression of Notch, c-Jun, and Krox-20 after nerve crush injury in adolescent and young adult rats. We hypothesized that these Schwann cell myelinating regulatory factors are down-regulated after nerve injury in an age-dependent fashion. Methods: Adolescent (2 months old) and young adult (12 months old) rats (n = 48) underwent sciatic nerve crush injury. Protein expression of Notch, c-Jun, and Krox-20 was quantified by Western blot analysis at 1, 3, and 7 days post-injury. Functional recovery was assessed in a separate group of animals (n = 8) by gait analysis (sciatic functional index) and electromyography (compound motor action potential) over an 8-week post-injury period. Results: Young adult rats demonstrated a trend of delayed onset of the dedifferentiating regulatory factors, Notch and c-Jun, corresponding to the delayed functional recovery observed in young adult rats compared to adolescent rats. Compound motor action potential area was significantly greater in adolescent rats relative to young adult rats, while amplitude and velocity trended toward statistical significance. Conclusions: The process of Schwann cell dedifferentiation following peripheral nerve injury shows different trends with age. These trends of delayed onset of key regulatory factors responsible for Schwann cell myelination may be one of many possible factors mediating the significant differences in functional recovery between adolescent and young adult rats following peripheral nerve injury.

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