Possible recurrent aseptic meningitis associated with nusinersen therapy

2020 ◽  
Vol 62 (5) ◽  
Author(s):  
Orly Moshe‐Lilie ◽  
Louis P. Riccelli ◽  
Chafic Karam
Keyword(s):  
Aseptic Meningitis ◽  
Recurrent Aseptic Meningitis

Naproxen-Induced Recurrent Aseptic Meningitis

DICP ◽  
1991 ◽  
Vol 25 (11) ◽  
pp. 1183-1184 ◽  
Author(s):  
Babette B. Weksler ◽  
Anne Marie Lehany
Keyword(s):  
Aseptic Meningitis ◽  
Recurrent Aseptic Meningitis

scholarly journals CN-13 * RECURRENT ASEPTIC MENINGITIS IN PATIENTS WITH METASTATIC BRAIN TUMORS; A NOVEL PERSPECTIVE

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v48-v49
Author(s):  
N. Majd ◽  
E. Neil ◽  
R. Warnick ◽  
J. Tew ◽  
R. Curry
Keyword(s):  
Brain Tumors ◽  
Aseptic Meningitis ◽  
Metastatic Brain Tumors ◽  
Recurrent Aseptic Meningitis

scholarly journals Il-1antagonist Treatment in Recurrent Aseptic Meningitis Related to Familial Mediterranean Fever

2020 ◽  
Author(s):  
Ruth Livny ◽  
Yuval Bitterman ◽  
Riva Brik ◽  
Yonatan Butbul Aviel
Keyword(s):  
Nervous System ◽  
Familial Mediterranean Fever ◽  
Aseptic Meningitis ◽  
Inflammatory Diseases ◽  
Case Reports ◽  
Interleukin 1 ◽  
Colchicine Treatment ◽  
Cns Involvement ◽  
Mediterranean Fever ◽  
Recurrent Aseptic Meningitis

Abstract Background Familial Mediterranean fever (FMF) is an autosomal recessive, auto-inflammatory disease, presenting with recurrent bouts of fever and polyserositis. FMF has been associated with central nervous system (CNS) manifestations such as Headache and Myalgia. The occurrence of other forms of nervous system involvement is rare, including seizures, sinus vein thrombosis, pseudotumor cerebri and more. There are only few case reports of aseptic meningitis due to FMF. Case presentation We present the case of a 14 year-old girl diagnosed with FMF, who experienced recurrent episodes of severe headache and aseptic meningitis while on maximal dose of colchicine therapy. She had a dramatic response to anakinra with symptoms resolving completely within a few days without recurrence. Subsequently, we identified seven cases in the literature describing recurrent aseptic meningitis in patients with underlying FMF; all showed response to colchicine treatment, without treatment failure. Conclusion Our case suggests a role for Interleukin 1 (IL-1) antagonists for cases of CNS involvement secondary to FMF in patients who fail to respond to colchicine, and might imply that anakinra could be effective in other auto-inflammatory diseases with CNS involvement.

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