Reproducibility of motor unit number index and MScanFit motor unit number estimation across intrinsic hand muscles

2020 ◽  
Vol 62 (2) ◽  
pp. 192-200 ◽  
Author(s):  
Mana Higashihara ◽  
Parvathi Menon ◽  
Mehdi Bos ◽  
Nathan Pavey ◽  
Steve Vucic
Author(s):  
Omid Rashidipour ◽  
K. Ming Chan

Motor unit number estimation (MUNE) is an electrophysiological method designed to quantify motor unit loss in target muscles of interest. Most of the techniques are noninvasive and are therefore well suited for longitudinal monitoring. In this brief review, we describe the more commonly used techniques and their applications in amyotrophic lateral sclerosis, poliomyelitis, spinal muscular atrophy and hereditary sensorimotor neuropathies. Findings in some of these studies offer important pathophysiological insights. Since conventional electrophysiologic methods are not sensible measures of motor neuronal loss, MUNE could play a potentially important role in the diagnosis, monitoring of disease progression and response to treatment in neuromuscular diseases in which motor unit loss is a major feature.


2006 ◽  
Vol 95 (6) ◽  
pp. 3371-3383 ◽  
Author(s):  
James P. Coxon ◽  
Cathy M. Stinear ◽  
Winston D. Byblow

Volitional inhibition is the voluntary prevention of a prepared movement. Here we ask whether primary motor cortex (M1) is a site of convergence of cortical activity associated with movement preparation and volitional inhibition. Volitional inhibition was studied by presenting a stop signal before execution of an anticipated response that requires a key lift to intercept a revolving dial. Motor evoked potentials (MEPs) were elicited in intrinsic hand muscles by transcranial magnetic stimulation (TMS) to assess corticomotor excitability and short interval intracortical inhibition (sICI) during task performance. The closer the stop cue was presented to the anticipated response, the harder it was for subjects to inhibit their response. Corticomotor pathway excitability was temporally modulated during volitional inhibition. Using subthreshold TMS, corticomotor excitability was reduced for Stop trials relative to Go trials from 140 ms after the cue. sICI was significantly greater for Stop trials compared with Go trials at a time that preceded the onset of muscle activity associated with the anticipated response. These results provide evidence that volitional inhibition is exerted at a cortical level and that inhibitory networks within M1 contribute to volitional inhibition of prepared action.


2018 ◽  
Vol 129 ◽  
pp. e80
Author(s):  
Christina S. Nielsen ◽  
Michael Vaeggemose ◽  
Anna B. Jacobsen ◽  
Anders Fuglsang-Frederiksen ◽  
Henning Andersen ◽  
...  

2012 ◽  
Vol 123 (9) ◽  
pp. e94
Author(s):  
Mana Higashihara ◽  
Masahiro Sonoo ◽  
Tomotaka Yamamoto ◽  
Yu Nagashima ◽  
Yasuo Terao ◽  
...  

1992 ◽  
Vol 17 (5) ◽  
pp. 804-809 ◽  
Author(s):  
Mark D. Jacobson ◽  
Rajnik Raab ◽  
Babak M. Fazeli ◽  
Reid A. Abrams ◽  
Michael J. Botte ◽  
...  

2021 ◽  
Vol 53 (8S) ◽  
pp. 165-166
Author(s):  
Sunggun Jeon ◽  
William Miller ◽  
Jun Seob Song ◽  
Xin Ye

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