Miconazole enhances nerve regeneration and functional recovery after sciatic nerve crush injury

2018 ◽  
Vol 57 (5) ◽  
pp. 821-828 ◽  
Author(s):  
Tao Lin ◽  
Shuai Qiu ◽  
Liwei Yan ◽  
Shuang Zhu ◽  
Canbin Zheng ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Crush Injury

Functional Recovery and Vitamin E Level Following Sciatic Nerve Crush Injury in Normal and Diabetic Rats

1998 ◽  
Vol 96 (3-4) ◽  
pp. 245-254 ◽  
Author(s):  
Khalaf Al Moutaery ◽  
Mohammed Arshaduddin ◽  
Mohammad Tariq ◽  
Saleh Al Deeb
Keyword(s):  
Vitamin E ◽  
Sciatic Nerve ◽  
Functional Recovery ◽  
Diabetic Rats ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Crush Injury

Functional Recovery After Facial and Sciatic Nerve Crush Injury in the Rat

2005 ◽  
Vol 7 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Tessa A. Hadlock ◽  
James Heaton ◽  
Mack Cheney ◽  
Susan E. Mackinnon
Keyword(s):  
Sciatic Nerve ◽  
Functional Recovery ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Crush Injury

Cinnamaldehyde Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats

2020 ◽  
Vol 209 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Zohreh Jahromi ◽  
Fahimeh Mohammadghasemi ◽  
Farshad Moharrami Kasmaie ◽  
Arash Zaminy
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Crush Injury ◽  
Vehicle Group ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Clinical Issue ◽  
Study Results

Peripheral nerve injury is a common clinical issue induced by trauma, tumor, and damage caused by treatment. Such factors create chemical and inflammatory alterations at the injury site, which increase nerve deterioration. Thus, minimizing these modifications can lead to nerve protection after injury. The present study sought to evaluate the possible improvement in nerve regeneration and enhancement of functional outcomes by cinnamaldehyde (Cin) administration following sciatic nerve crush in a rat model. Rats (n = 48) were distributed into 6 groups, including sham, injury, DMSO (vehicle group), and Cin groups (10, 30, and 90 mg/kg/day). Using small hemostatic forceps, crush injury was induced in the left sciatic nerve. Thereafter, Cin was administered for 28 successive days. Weekly records were taken for sciatic functional index (SFI) measurements. Further assessments including electrophysiological and histomorphometric evaluations, gastrocnemius muscle wet weight measurements, and estimation of the serum total oxidant status were performed. According to the results, Cin could accelerate sciatic nerve recovery after crush injury, and the dose of 30 mg/kg/day of Cin had better impacts on SFI recovery, muscle mass ratio, and myelin content. The current research demonstrated that Cin positively affects peripheral nerve restoration. Therefore, Cin therapy could be considered as a potential treatment method for peripheral nerve regeneration and its functional recovery. However, more investigations are required to further validate the study results and evaluate the optimal dose of Cin.

scholarly journals Erythropoietin accelerates functional recovery after moderate sciatic nerve crush injury

2017 ◽  
Vol 56 (1) ◽  
pp. 143-151 ◽  
Author(s):  
Michael B. Geary ◽  
Haiyan Li ◽  
Alissa Zingman ◽  
John Ketz ◽  
Michael Zuscik ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Functional Recovery ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Crush Injury
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