scholarly journals Chronic nerve compression alters schwann cell myelin architecture in a murine model

2012 ◽  
Vol 45 (2) ◽  
pp. 231-241 ◽  
Author(s):  
Ranjan Gupta ◽  
Nima Nassiri ◽  
Antony Hazel ◽  
Mary Bathen ◽  
Tahseen Mozaffar
Keyword(s):  
Schwann Cell ◽  
Murine Model ◽  
Nerve Compression ◽  
Chronic Nerve Compression

scholarly journals Understanding the mechanisms of entrapment neuropathies

2009 ◽  
Vol 26 (2) ◽  
pp. E7 ◽  
Author(s):  
Khoa Pham ◽  
Ranjan Gupta
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Axonal Injury ◽  
Reciprocal Relationship ◽  
Nerve Compression ◽  
Nerve Tissue ◽  
Myelin Proteins ◽  
Mechanical Stimuli ◽  
Entrapment Neuropathies ◽  
Chronic Nerve Compression

Compression neuropathies are highly prevalent, debilitating conditions with variable functional recovery following surgical decompression. Due to the limited amount of human nerve tissue available for analysis, a number of animal models have been created to help investigators understand the molecular and cellular pathogenesis of chronic nerve compression (CNC) injury. Evidence suggests that CNC injury induces concurrent Schwann cell proliferation and apoptosis in the early stages of the disorder. These proliferating Schwann cells downregulate myelin proteins, leading to local demyelination and remyelination in the region of injury. In addition, the downregulation of myelin proteins, in particular myelin-associated glycoprotein, allows for axonal sprouting. Interestingly, these changes occur in the absence of both morphological and electrophysiological evidence of axonal damage. This is in direct contrast to acute injuries, such as transection or crush, which are characterized by axonal injury followed by Wallerian degeneration. Because the accepted trigger for Schwann cell dedifferentiation is axonal injury, an alternate mechanism for Schwann response must exist in CNC injury. In vitro studies of pure Schwann cells have shown that these cells can respond directly to mechanical stimuli by downregulating myelin proteins and proliferating. These studies suggest that although the reciprocal relationship between neurons and glial cells is maintained, chronic nerve compression injury is a Schwann cell-mediated disease.

An Experimental Model of Chronic Nerve Compression in the Rat

2005 ◽  
Vol 40 (6) ◽  
pp. 763
Author(s):  
Sang Jin Cheon ◽  
Young Ho Kim ◽  
Dong Ho Lee ◽  
Gi Yeong Huh ◽  
Hui Taek Kim ◽  
...  
Keyword(s):  
Experimental Model ◽  
Nerve Compression ◽  
Chronic Nerve Compression

Correction to “Sustained Local Release of NGF from a Chitosan-Sericin Composite Scaffold for Treating Chronic Nerve Compression”

2020 ◽  
Vol 12 (2) ◽  
pp. 3276-3276
Author(s):  
Lei Zhang ◽  
Wen Yang ◽  
Kaixiong Tao ◽  
Yu Song ◽  
Hongjian Xie ◽  
...  
Keyword(s):  
Composite Scaffold ◽  
Nerve Compression ◽  
Chronic Nerve Compression ◽  
Local Release

A Primate Model for Chronic Nerve Compression

1985 ◽  
Vol 1 (03) ◽  
pp. 185-194 ◽  
Author(s):  
Susan Mackinnon ◽  
A. Dellon ◽  
Alan Hudson ◽  
Daniel Hunter
Keyword(s):  
Nerve Compression ◽  
Primate Model ◽  
Chronic Nerve Compression

A Model of Chronic Nerve Compression in the Rat

1987 ◽  
Vol 19 (5) ◽  
pp. 430-435 ◽  
Author(s):  
J. P. OʼBrien ◽  
S. E. Mackinnon ◽  
A. R. MacLean ◽  
A. R. Hudson ◽  
A. L. Dellon ◽  
...  
Keyword(s):  
Nerve Compression ◽  
Chronic Nerve Compression
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