scholarly journals Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis

2011 ◽  
Vol 45 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Christopher L. Mendias ◽  
Jonathan P. Gumucio ◽  
Max E. Davis ◽  
Caleb W. Bromley ◽  
Carol S. Davis ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Muscle Atrophy ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Skeletal Muscle Atrophy ◽  
Growth Factor Beta

scholarly journals Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation

2016 ◽  
Vol 40 (1-2) ◽  
pp. 27-38 ◽  
Author(s):  
Johanna Ábrigo ◽  
Felipe Simon ◽  
Daniel Cabrera ◽  
Claudio Cabello-Verrugio
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Western Blot ◽  
Muscle Atrophy ◽  
Transforming Growth Factor ◽  
Fibre Diameter ◽  
Skeletal Muscle Atrophy ◽  
Mas Receptor ◽  
Factor Type ◽  
Tgf Β1

Background: Transforming growth factor type beta 1 (TGF-β1) produces skeletal muscle atrophy. Angiotensin-(1-7) (Ang-(1-7)), through the Mas receptor, prevents the skeletal muscle atrophy induced by sepsis, immobilization, or angiotensin II (Ang-II). However, the effect of Ang-(1-7) on muscle wasting induced by TGF-β1 is unknown. Aim: To evaluate whether Ang-(1-7)/Mas receptor axis could prevent the skeletal muscle atrophy induced by TGF-β1. Methods: This study assessed the atrophic effect of TGF-β1 in C2C12 myotubes and mice in absence or presence of Ang-(1-7), and the receptor participation using A779, an antagonist of the Mas receptor. The levels of myosin heavy chain (MHC), polyubiquitination, and MuRF-1 were detected by western blot. Myotube diameter was also evaluated. In vivo analysis included the muscle strength, fibre diameter, MHC and MuRF-1 levels by western blot, and ROS levels by DCF probe detection. Results: The results showed that Ang-(1-7) prevented the increase in MuRF-1 and polyubiquitined protein levels, the decrease of MHC levels, the myotubes/fibre diameter diminution, and the increased production of reactive oxygen species (ROS) induced by TGF-β1. Utilizing A779 inhibited the anti-atrophic effect of Ang-(1-7). Conclusion: The preventive effect of Ang-(1-7) on skeletal muscle atrophy induced by TGF-β1 is produced through inhibition of ROS production and proteasomal degradation of MHC.

Transforming growth factor type beta (TGF-β) requires reactive oxygen species to induce skeletal muscle atrophy

2016 ◽  
Vol 28 (5) ◽  
pp. 366-376 ◽  
Author(s):  
Johanna Abrigo ◽  
Juan Carlos Rivera ◽  
Felipe Simon ◽  
Daniel Cabrera ◽  
Claudio Cabello-Verrugio
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Growth Factor ◽  
Muscle Atrophy ◽  
Transforming Growth Factor ◽  
Reactive Oxygen ◽  
Skeletal Muscle Atrophy ◽  
Oxygen Species ◽  
Factor Type

scholarly journals An inhibitor of transforming growth factor beta type I receptor ameliorates muscle atrophy in a mouse model of caveolin 3-deficient muscular dystrophy

2012 ◽  
Vol 92 (8) ◽  
pp. 1100-1114 ◽  
Author(s):  
Yutaka Ohsawa ◽  
Tadashi Okada ◽  
Shin-ichiro Nishimatsu ◽  
Masatoshi Ishizaki ◽  
Tomohiro Suga ◽  
...  
Keyword(s):  
Growth Factor ◽  
Muscular Dystrophy ◽  
Mouse Model ◽  
Muscle Atrophy ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Type I ◽  
Growth Factor Beta
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