Chemotherapy is successful in sporadic late onset nemaline myopathy (SLONM) with monoclonal gammopathy

2009 ◽  
Vol 41 (2) ◽  
pp. 286-287 ◽  
Author(s):  
Jan Novy ◽  
Anne Rosselet ◽  
Olivier Spertini ◽  
Johannes Alexander Lobrinus ◽  
Thomas Pabst ◽  
...  
Keyword(s):  
Monoclonal Gammopathy ◽  
Late Onset ◽  
Nemaline Myopathy

scholarly journals Inflammatory features in sporadic late‐onset nemaline myopathy are independent from monoclonal gammopathy

2021 ◽  
Vol 31 (3) ◽  
Author(s):  
Jantima Tanboon ◽  
Akinori Uruha ◽  
Yukie Arahata ◽  
Carsten Dittmayer ◽  
Leonille Schweizer ◽  
...  
Keyword(s):  
Monoclonal Gammopathy ◽  
Late Onset ◽  
Nemaline Myopathy

Sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance: Report of four patients

2021 ◽  
Vol 31 (1) ◽  
pp. 29-34
Author(s):  
Ali Asghar Okhovat ◽  
Yalda Nilipour ◽  
Reza Boostani ◽  
Fahimeh Vahabizad ◽  
Safa Najmi ◽  
...  
Keyword(s):  
Monoclonal Gammopathy ◽  
Late Onset ◽  
Nemaline Myopathy ◽  
Undetermined Significance

scholarly journals Sporadic late onset nemaline myopathy with monoclonal gammopathy of undetermined significance: two cases with long term stability

2020 ◽  
Vol 30 (3) ◽  
Author(s):  
André Truffert ◽  
Ruxandra Iancu Ferfoglia ◽  
Johannes Alexander Lobrinus ◽  
Kaveh Samii ◽  
André Kohler
Keyword(s):  
Monoclonal Gammopathy ◽  
Late Onset ◽  
Autologous Bone Marrow Transplantation ◽  
Autologous Bone Marrow ◽  
Nemaline Myopathy ◽  
Cardiac Insufficiency ◽  
Long Term Stability ◽  
First Case ◽  
One Year ◽  
Undetermined Significance

Monoclonal gammopathy of undetermined significance (MGUS) associated to sporadic late onset nemaline myopathy (SLONM) is a rare and severely disabling condition of quickly progressive limb girdle acquired myopathy. It is believed by some authors to be due to myotoxicity of light chain deposits. Two female patients were diagnosed with MGUS associated SLONM. In the first case, diagnosis was delayed by 6 years thus giving time for a severe generalized myopathy and cardiomyopathy to develop. A single anti-myeloma chemotherapy with lenalidomide markedly improved and stabilized the patient’s condition despite respiratory and cardiac insufficiency. In our second patient the condition was identified one year after onset of the first symptom and markedly improved after autologous bone marrow transplantation and lenalidomide. Clinicians should be aware of monoclonal gammopathy associated sporadic late onset nemaline myopathy as this acquired muscle disorder, although extremely rare, may be reversed by adequate management.

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